Epinephrine before defibrillation in patients with shockable in-hospital cardiac arrest: propensity matched analysis.

Objective: To determine the use of epinephrine (adrenaline) before defibrillation for treatment of in-hospital cardiac arrest due to a ventricular arrhythmia and examine its association with patient survival.

Design: Propensity matched analysis.

Setting: 2000-18 data from 497 hospitals participating in the American Heart Association’s Get With The Guidelines-Resuscitation registry.

Coordinate regulation of sphingosine kinase and actin dynamics.

The activation of lipid-modifying enzymes generally involves a physical change in their interactions with the membrane substrate. For sphingosine kinase, a predominantly cytosolic enzyme in resting cells, activation is accompanied by translocation to specific subsets of cellular membranes where catalysis occurs. As all eukaryotic membranes have a tightly associated filamentous actin skeleton, we investigated potential regulatory interactions between sphingosine kinase and actin.