6,999 results match your criteria: "Investigative Radiology[Journal]"
Safety of Gadopiclenol After Its First Year of Clinical Use.
Invest Radiol
November 2024
From Global Medical and Regulatory Affairs, Bracco Group, Milan, Italy (A.S., L.V., G.P., M.A.K.); and Medical, Pharmacovigilance, and Regulatory Affairs, Guerbet Group, Villepinte, France (E.L., C.C., A.J., E.D.-K., P.B.).
Gadopiclenol is a novel, macrocyclic high-relaxivity gadolinium-based contrast agent recently approved for use in magnetic resonance imaging of the central nervous system and body organs at a dose of 0.05 mmol/kg body weight. Postmarketing surveillance of its first year of clinical use in the United States of America showed no serious adverse events (AEs) following over 882,550 administrations and a very low rate of nonserious AEs (1 case every 27,580 exposures).
View Article and Find Full Text PDFMetastasis Detection Using True and Artificial T1-Weighted Postcontrast Images in Brain MRI.
Invest Radiol
November 2024
From the Department of Diagnostic and Interventional Neuroradiology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany (R.H., E.K., Z.B., D.P., R.C., A.R., K.D.); Institute of Applied Mathematics, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany (T.P., A.E.); Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.P.); Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (D.P., H.-P.S.); Department of Diagnostic and Interventional Radiology With Nuclear Medicine, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany (M.F.-D., K.S., G.H., C.P.H.); Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany (M.F.-D.); Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany (V.W., C.P.H.); Translational Lung Research Center Heidelberg, Member of the German Center of Lung Research (DZL), Heidelberg, Germany (C.P.H.); Praxisnetz, Radiology and Nuclear Medicine, Bonn, Germany (M.V.); Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, Bonn, Germany (J.A.L.); Chair of Civil Law, Data Protection Law, Law of Data Economy, Digitalization and AI Law, Faculty of Law, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany (L.S.-R.); and German Center for Neurodegenerative Diseases (DZNE), Helmholtz Association of German Research Centers, Venusberg-Campus 1, Bonn, Germany (A.R., K.D.).
Objectives: Small lesions are the limiting factor for reducing gadolinium-based contrast agents in brain magnetic resonance imaging (MRI). The purpose of this study was to compare the sensitivity and precision in metastasis detection on true contrast-enhanced T1-weighted (T1w) images and artificial images synthesized by a deep learning method using low-dose images.
Materials And Methods: In this prospective, multicenter study (5 centers, 12 scanners), 917 participants underwent brain MRI between October 2021 and March 2023 including T1w low-dose (0.
Leveraging Phase Information of 3D Isotropic Ultrashort Echo Time Pulmonary MRI for the Detection of Thoracic Lymphadenopathy: Toward an All-in-One Scan Solution.
Invest Radiol
November 2024
From the Department of Diagnostic and Interventional Radiology, School of Medicine & Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany (S.Z., A.T.V., A.W.M., T.L., F.S., T.H., A.S., J.G., M.R.M., D.C.K., M.G.); Philips GmbH, Hamburg, Germany (K.W.); and Philips North America, Nashville, TN (R.R.).
Background: Ultrashort echo time (UTE) allows imaging of tissues with short relaxation times, but it comes with the expense of long scan times. Magnitude images of UTE magnetic resonance imaging (MRI) are widely used in pulmonary imaging due to excellent parenchymal signal, but have insufficient contrast for other anatomical regions of the thorax. Our work investigates the value of UTE phase images (UTE-Ps)-generated simultaneously from the acquired UTE signal used for the magnitude images-for the detection of thoracic lymph nodes based on water-fat contrast.
View Article and Find Full Text PDFPancreatic Intraepithelial Neoplasia Revealed by Diffusion-Tensor MRI.
Invest Radiol
December 2024
From the Radiology Department, Champalimaud Foundation, Lisbon, Portugal (C.B., C.M.); Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal (C.B., F.F.F., R.H., C.C., A.I., M.C.-M., T.C., C.M., N.S.); Nova Medical School, Lisbon, Portugal (C.B.); i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal (R.V.S.); and Pathology Department, Champalimaud Foundation, Lisbon, Portugal (M.C.-M.).
Objectives: Detecting premalignant lesions for pancreatic ductal adenocarcinoma, mainly pancreatic intraepithelial neoplasia (PanIN), is critical for early diagnosis and for understanding PanIN biology. Based on PanIN's histology, we hypothesized that diffusion tensor imaging (DTI) and T2* could detect PanIN.
Materials And Methods: DTI was explored for the detection and characterization of PanIN in genetically engineered mice (KC, KPC).
Differentiating Glioma Recurrence and Pseudoprogression by APTw CEST MRI.
Invest Radiol
December 2024
From the Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany (K.K.-J., N.E., E.G., K.S., J.U., H.F.-P., D.S., V.S., J.M.K., I.P., S.H., M.B., M.O.B.); Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany (K.K.-J., F.W., W.W.); Department of Neurology, Heidelberg University Hospital and National Center for Tumor Diseases (NCT), Heidelberg, Germany (D.B., F.M.I., F.W., W.W.); DKTK, DKFZ, Clinical Cooperation Unit Neuropathology, Heidelberg, Germany (F.M.I.); Division of Radiology, DKFZ, Heidelberg, Germany (N.V., D.P.); Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, DKTK, DKFZ, Heidelberg, Germany (L.B., M.P., M.O.B.); Department of Neurology, Medical Faculty Mannheim, Mannheim Center for Translational Neurosciences, Heidelberg University, Mannheim, Germany (L.B., M.P.); Division of Neuroradiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (D.P.); and Clinic for Neuroradiology, University Hospital Bonn, Bonn, Germany (D.P.).
Article Synopsis
Gadolinium Elimination in a Gadolinium Deposition Disease Population After a Single Exposure to Gadolinium-Based Contrast Agents.
Invest Radiol
December 2024
From the Department of Neuroradiology, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal (J.R.); Department of Radiology, Hospital da Luz, Lisbon, Portugal (M.R.); and Richard Semelka Consulting, PLLC, Chapel Hill, NC (R.C.S.).
Article Synopsis
- - This study explores how gadolinium (Gd) levels in urine change over time after patients receive a Gd-based contrast agent (GBCA) for MRI, particularly focusing on those with Gd deposition disease.
- - It involved 45 subjects with normal kidney function, who underwent urine tests to measure Gd concentration 24 hours after receiving a GBCA, and the results indicated that Gd levels remained above normal for 3 months.
- - The findings suggest that Gd is retained in the body and is eliminated through urine in a predictable logarithmic pattern, regardless of the type of GBCA used, with significant levels observed at 1 month and a gradual decline over the following months.
Contrast-Enhanced Digital Breast Tomosynthesis Compared With Contrast-Enhanced Mammography and Magnetic Resonance Imaging in the Assessment of Breast Lesions: A Pilot Study.
Invest Radiol
December 2024
From the Division of General and Pediatric Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria (P.C., N.P., A.S., M.W., P.A.T.B., T.H.H.); Catholic University of the Sacred Heart, Institute of Radiology, Rome, Italy (F.F.); Department of Radiology Section of Breast Imaging, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia (L.Z.); and Diagnostic Imaging, Siemens Healthcare GmbH, Forchheim, Germany (M.H.).
Article Synopsis
Impact of a Prototype 29:1 Ratio Grid on Image Quality and Radiation Dose in Abdominal Angiography: Evaluation in a Pig Model.
Invest Radiol
December 2024
From the Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany (T.W., S.K.M., F.K.W., B.C.M.); Section of Interventional Radiology, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT (L.S.B.); and Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hanover, Germany (I.B., R.R.).
Objectives: The aim of this study was to evaluate the impact of a prototype grid with a 29:1 ratio (r29) and a 15:1 (r15) grid on the image quality (IQ) and radiation dose in abdominal angiography.
Materials And Methods: Six typical abdominal angiographic image scenarios were created in 4 pigs. Polymethylmethacrylate and aluminum plates were used to add 10 cm of patient equivalent thickness to simulate different body types.
Relevance of Prostatic Fluid on the Apparent Diffusion Coefficient: An Inversion Recovery Diffusion-Weighted Imaging Investigation.
Invest Radiol
December 2024
From the Institute of Radiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (D.S., S.B., M.B., R.J., M.M., F.G., D.H., M.U., F.B.L.); Section for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Tübingen, Germany (M.M.); Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (T.A.K.); Institute of Neuroradiology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (M.Z.); and Department of Artificial Intelligence in Biomedical Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (M.Z.).
Article Synopsis
Molecular Ultrasound Imaging With Clinically Translatable cRGD-Coated Microbubbles to Assess αvβ3-Integrin Expression in Inflammatory Bowel Disease.
Invest Radiol
November 2024
From the Institute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany (J.Q., J.C., P.K., Y.S., A.R., F.K.); and Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany (S.V.).
Objectives: Inflammatory bowel disease (IBD) subdivides into Crohn disease (CD) and ulcerative colitis (UC), and is characterized by unpredictable periods of inflammation and results in significant patient suffering and even death. Conventional diagnostic methods, for example, colonoscopy, computed tomography, or magnetic resonance imaging, have limitations such as invasiveness, patient discomfort, and limited sensitivity and accuracy. Therefore, we propose ultrasound molecular imaging (USMI) to detect and characterize IBD.
View Article and Find Full Text PDFRisk of Contrast-Induced Acute Kidney Injury in Computed Tomography: A 16 Institutional Retrospective Cohort Study.
Invest Radiol
December 2024
From the Department of Biomedical Informatics, Ajou University Graduate School of Medicine, Suwon, South Korea (B.C., S.S., S.G., B.P., R.W.P.); Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (S.H., S.H.C., S.H.P.); Department of Radiology, Mayo Clinic Rochester, Rochester, MN (J.S.M.); Department of Gastroenterology, Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (W.-M.C.); Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (J.B.L.); Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX (E.A.L.); Office of Biostatistics, Medical Research Collaborating Center, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon, South Korea (B.P.); Department of Nephrology, Ajou University School of Medicine, Suwon, South Korea (H.J.C.); Department of Radiology, Keimyung University, Dongsan Hospital, Daegu, South Korea (B.J.K.); Department of Endocrinology and Metabolism, Kyung Hee University College of Medicine, Seoul, South Korea (S.Y.R.); Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea (S.B.H.); Division of Cardiology, Incheon Sejong Hospital, Incheon, South Korea (K.-H.K.); Department of Radiology, School of Medicine, Catholic University of Daegu, South Korea (Y.H.L.); and Department of Radiology, Soonchunhyang University College of Medicine, Cheonan Hospital, Cheonan-si, Chungcheongnam-do, South Korea (S.S.K.).
Objectives: Concern about contrast-induced acute kidney injury (CI-AKI) may delay the timely administration of contrast media for computed tomography (CT). The precise causative effect of iodinated contrast media on CI-AKI and its relevant risk factors remains an area of ongoing investigation. Therefore, this study aimed to determine the risk of CI-AKI following contrast-enhanced CT and its predisposing risk factors.
View Article and Find Full Text PDFImproved MR Detection of Optic Nerve Demyelination With MP2RAGE-FLAWS Compared With T2-Weighted Fat-Saturated Sequences.
Invest Radiol
November 2024
From the Department of Neuroradiology, AP-HP, Henri Mondor University Hospital, Créteil, France (R.A., T.E., I.M., B.B.); University Paris Est Créteil, INSERM, IMRB, Créteil, France (N.O.); Department of Public Health, AP-HP, Henri Mondor University Hospital, Créteil, France (N.O.); EA 4391, Université Paris Est Créteil, Créteil, France (A.C., B.B.); Department of Neurology, AP-HP, Henri Mondor University Hospital, Créteil, France (A.C.); Department of Neuroradiology, A. Rothschild Foundation Hospital, Paris, France (A.L.); Paris Cité University, Paris, France (A.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.K.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.K.); Signal Processing Laboratory (LTS 5), École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.K.); and Siemens Healthcare SAS, Courbevoie, France (A.M.).
Objectives: Nonenhanced T1-w sequences such as magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) and derived fluid and white matter suppression (FLAWS) have demonstrated high performance for detecting brain parenchymal and cervical spine demyelinating lesions in multiple sclerosis. However, their potential for identifying optic nerve (ON) demyelination remains unexplored. The aim of this study was to evaluate the performance of compressed sensing-accelerated (CS) MP2RAGE-FLAWS imaging for detection of ON demyelination lesions compared with T2-w fat-saturated (FS) TSE imaging in a clinical setting.
View Article and Find Full Text PDFMRI Dixon Fat-Corrected Look-Locker T1 Mapping for Quantification of Liver Fibrosis and Inflammation-A Comparison With the Non-Fat-Corrected Shortened Modified Look-Locker Inversion Recovery Technique.
Invest Radiol
November 2024
From the Department of Diagnostic, Interventional, and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (J.B.K., B.J., L.E., A.C., V.C.O., A.T.H.); Institute of Forensic Medicine, University of Bern, Bern, Switzerland (J.B.K.); Dr. Kurz Röntgeninstitut AG, Thun, Switzerland (J.B.K.); Siemens Medical Solutions USA, Tucson, AZ (U.G., M.K.); Siemens Medical Solutions USA, New York, NY (M.B.K.); Department of Hepatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (A.B.); Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, University of Lucerne, Lucerne, Switzerland (L.E., J.R., A.T.H.); and Liver Elastography Center, Translational Imaging Center, Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland (A.C., V.C.O., A.T.H.).
Objectives: This study evaluates the impact of liver steatosis on the discriminative ability for liver fibrosis and inflammation using a novel Dixon water-only fat-corrected Look-Locker T1 mapping sequence, compared with a standard shortened Modified Look-Locker Inversion Recovery (shMOLLI) sequence, with the aim of overcoming the limitation of steatosis-related confounding in liver T1 mapping.
Materials And Methods: 3 T magnetic resonance imaging of the liver including the 2 T1 mapping sequences and proton density fat fraction (PDFF) was prospectively performed in 24 healthy volunteers and 38 patients with histologically proven liver fibrosis evaluated within 90 days of liver biopsy. Paired Mann-Whitney test compared sequences between participants with and without significant liver steatosis (PDFF cutoff 10%), and unpaired Kruskal-Wallis test compared healthy volunteers to patients with early (F0-2) and advanced (F3-4) liver fibrosis, as well as low (A0-1) and marked (A2-3) inflammatory activity.
Epineural Scarring Visualization and Noninvasive Quantification of a Severe Posttraumatic Complication: An Experimental Magnetic Resonance Neurography Study.
Invest Radiol
November 2024
From the Department of Neuroradiology, Neurological University Clinic, Heidelberg University Hospital, Heidelberg, Germany (M.B., M.F., K.K.-J., M.O.B., S.H., M.B., D.S.); and Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwigshafen, Germany (M.A., M.M.-S., S.C.D., T.K., U.K., L.H., A.H.B.).
Article Synopsis
Photon-Counting CT Iodine Maps for Diagnosing Chronic Pulmonary Thromboembolism: A Pilot Study.
Invest Radiol
November 2024
From the Diagnostic and Interventional Radiology, University Hospital Zurich, University Zurich, Zurich, Switzerland (B.K., T.F., T.F., S.F.); Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, the Netherlands (T.F.); and Clinic of Pulmonology, University Hospital Zurich, Zurich, Switzerland (S.U., M.L.).
Objectives: The aim of this study was to evaluate the feasibility and efficacy of chronic pulmonary thromboembolism assessment using photon-counting detector computed tomography (PCD-CT) iodine maps of the lung parenchyma.
Materials And Methods: This institutional review board-approved retrospective study included 83 subjects (49.4% male, aged 62.
Low-Field MRI for Dental Imaging in Pediatric Patients With Supernumerary and Ectopic Teeth: A Comparative Study of 0.55 T and Ultra-Low-Dose CT.
Invest Radiol
October 2024
From the Department of Orthodontics and Orofacial Orthopedics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany (I.W., S.E., L.G.); Imaging Science Institute, University Hospital Erlangen, Erlangen, Germany (H.-P.F., P.A.); Department of Radiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany (M.S.M., M.Z., M.U., M.K.); and Center for Clinical Studies, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany (A.S.).
Objectives: This study sought to elucidate the diagnostic performance of 0.55 T magnetic resonance imaging (MRI) for pediatric dental imaging, specifically in terms of the image quality (IQ) for detecting ectopic and/or supernumerary teeth, compared with routine ultra-low-dose computed tomography (ULD-CT) of the jaw.
Materials And Methods: A total of 16 pediatric patients (mean age: 12.
Relaxivity and In Vivo Human Performance of Brand Name Versus Generic Ferumoxytol.
Invest Radiol
October 2024
From the Department of Radiology, University of Wisconsin-Madison, Madison, WI (R.A.V., D.T., J.R., S.B.R.); Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands (R.A.V.); Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI (L.M.); Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI (J.R.); Department of Medical Physics, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI (S.B.R.); Department of Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.); and Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI (S.B.R.).
Objectives: Ferumoxytol is a superparamagnetic iron-oxide product that is increasingly used off-label for contrast-enhanced magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). With the recent regulatory approval of generic ferumoxytol, there may be an opportunity to reduce cost, so long as generic ferumoxytol has similar imaging performance to brand name ferumoxytol. This study aims to compare the relaxation-concentration dependence and MRI performance of brand name ferumoxytol with generic ferumoxytol through phantom and in vivo experiments.
View Article and Find Full Text PDFThree-Dimensional Magnetic Resonance Imaging in the Musculoskeletal System: Clinical Applications and Opportunities to Improve Imaging Speed and Resolution.
Invest Radiol
October 2024
From The Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD (S.A., N.K., A.G., L.M.F.); Department of Orthopedic Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD (L.M.F.); and Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD (L.M.F.).
Although conventional 2-dimensional magnetic resonance (MR) sequences have traditionally comprised the foundational imaging strategy for visualization of musculoskeletal anatomy and pathology, the emergence of isotropic volumetric 3-dimensional sequences offers to advance musculoskeletal evaluation with comparatively similar image quality and diagnostic performance, shorter acquisition times, and the added advantages of improved spatial resolution and multiplanar reformation capability. The purpose of this review article is to summarize the available 3-dimensional MR sequences and their role in the management of patients with musculoskeletal disorders, including sports imaging, rheumatologic conditions, peripheral nerve imaging, bone and soft tissue tumor imaging, and whole-body MR imaging.
View Article and Find Full Text PDFA Quantitative Comparison Between Human and Artificial Intelligence in the Detection of Focal Cortical Dysplasia.
Invest Radiol
November 2024
From the Department of Neuroradiology, University Hospital Bonn, Bonn, Germany (L.W., T. Bauer, M.H.S., F.G., A.L., F.C.S., A. Radbruch, T.R.); Department of Epileptology, University Hospital Bonn, Bonn, Germany (L.W., T. Bauer, M.H.S., F. Schuch, T. Baumgartner, K.O.D., L.O., J.P., A. Racz, K.v.d.R., A.U.-P., P.v.W., R.v.W., R.S., T.R.); German Center for Neurodegenerative Diseases, Bonn, Germany (D.K., M.R., A. Radbruch); Department of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany (C.A., E.N., E.H.); Department of Neurology, University Hospital Bonn, Bonn, Germany (J.B., J.N.); Department of Neurosurgery, University Hospital Bonn, Bonn, Germany (V.B., M. Vychopen, H.V.); Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany (C.E., C.I., P.K., A.L., A.-M.O., M. Voigt, U.A.); Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany (M.K., S.M., F. Schrader, A.S., A.P.); Chair of Economic & Social Policy, WHU-Otto Beisheim School of Management, Vallendar, Germany (P.v.W.); Department of Neuropathology, University Hospital Bonn, Bonn, Germany (A.B.); A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA (M.R.); Department of Radiology, Harvard Medical School, Boston, MA (M.R.); Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom (J.W.S.); Chalfont Centre for Epilepsy, Chalfont St Peter, United Kingdom (J.W.S.); Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherland (J.W.S.); Department of Neurology, West China Hospital, Sichuan University, Chengdu, China (J.W.S.); and Center for Medical Data Usability and Translation, University of Bonn, Bonn, Germany (A. Radbruch, T.R.).
Objectives: Artificial intelligence (AI) is thought to improve lesion detection. However, a lack of knowledge about human performance prevents a comparative evaluation of AI and an accurate assessment of its impact on clinical decision-making. The objective of this work is to quantitatively evaluate the ability of humans to detect focal cortical dysplasia (FCD), compare it to state-of-the-art AI, and determine how it may aid diagnostics.
View Article and Find Full Text PDFSignificance of Image Reconstruction Parameters for Future Lung Cancer Risk Prediction Using Low-Dose Chest Computed Tomography and the Open-Access Sybil Algorithm.
Invest Radiol
October 2024
From the Division of Thoracic Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA (J.S., A.G., F.J.F.); Harvard Medical School, Boston, MA (J.S., A.E.B.C., S.J.S., L.V.S., F.J.F.); Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (P.M.); Jameel Clinic, Massachusetts Institute of Technology, Cambridge, MA (P.M.); Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA (A.E.B.C., L.V.S.); Department of Medicine, MGH Biostatistics, Massachusetts General Hospital, Boston MA (S.J.S.); and Multidisciplinary Thoracic Oncology Program, Baptist Cancer Center, Memphis, TN (R.U.O.).
Purpose: Sybil is a validated publicly available deep learning-based algorithm that can accurately predict lung cancer risk from a single low-dose computed tomography (LDCT) scan. We aimed to study the effect of image reconstruction parameters and CT scanner manufacturer on Sybil's performance.
Materials And Methods: Using LDCTs of a subset of the National Lung Screening Trial participants, which we previously used for internal validation of the Sybil algorithm (test set), we ran the Sybil algorithm on LDCT series pairs matched on kilovoltage peak, milliampere-seconds, reconstruction interval, reconstruction diameter, and either reconstruction filter or axial slice thickness.
A Comprehensive and Repeatable Contrast-Enhanced Ultrasound Quantification Approach for Clinical Evaluations of Tumor Blood Flow.
Invest Radiol
October 2024
From the Department of Bioengineering, University of Washington, Seattle, WA (C.K., A.W., M.S., M.A.); and Department of Radiology, University of Washington, Seattle, WA (M.D.).
Objective: The aim of this study is to define a comprehensive and repeatable contrast-enhanced ultrasound (CEUS) imaging protocol and analysis method to quantitatively assess lesional blood flow. Easily repeatable CEUS evaluations are essential for longitudinal treatment monitoring. The quantification method described here aims to provide a structure for future clinical studies.
View Article and Find Full Text PDFImplementation of an AI Algorithm in Clinical Practice to Reduce Missed Incidental Pulmonary Embolisms on Chest CT and Its Impact on Short-Term Survival.
Invest Radiol
October 2024
From the Institute of Radiology, Cantonal Hospital Aarau, Aarau, Switzerland (V.I.J.G., S.L., A.S., H.Z., F.B., S.S., T.S.); General Research Office, Cantonal Hospital Aarau, Aarau, Switzerland (C.G.); and Medical University Department, Division of General Internal and Emergency Medicine, Cantonal Hospital Aarau, Aarau, Switzerland (P.S.).
Article Synopsis
- - This study investigates the effectiveness of an artificial intelligence (AI) algorithm in detecting incidental pulmonary embolisms (iPEs) in chest CT scans, comparing results before and after the AI implementation.
- - It analyzed data from 5,298 CT scans, revealing that prior to AI use, radiologists missed around 50% of iPE cases, with the AI achieving high sensitivity (95%) and specificity (99%) in identifying suspicious iPEs.
- - The study also aimed to assess the anatomical distribution of missed iPE cases and evaluate mortality rates in patients within 90 days following the different detection methods.
7 T Lumbosacral Plexus Neurography: Feasibility and Comparison of Spinal Nerve Visualization With 3 T MRI.
Invest Radiol
August 2024
From the Department of Radiology, Balgrist University Hospital, Zurich, Switzerland (A.A.M., G.C.F., R.S.); Swiss Center for Musculoskeletal Imaging, Balgrist Campus AG, Zurich, Switzerland (A.A.M., D.N.); Department of Orthopedic Surgery, Balgrist University Hospital, Zurich, Switzerland (F.W.); and Medical Faculty, University of Zurich, Zurich, Switzerland (D.N., R.S.).
Article Synopsis
- This study explored the feasibility of 7 T MR neurography for imaging the lumbosacral plexus, comparing it to standard 3 T MR neurography in healthy subjects.
- Results showed that 7 T MRI significantly improved the visibility of lumbar nerve structures, but it also introduced more image artifacts.
- While overall image quality was similar between the two techniques, the improved visualization capabilities of 7 T MR neurography suggest it is a promising option for studying the lumbosacral plexus despite the increased artifacts.
Deep Learning-Enhanced Accelerated 2D TSE and 3D Superresolution Dixon TSE for Rapid Comprehensive Knee Joint Assessment.
Invest Radiol
August 2024
From the imec-Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium (C.S., Q.B., J.S., B.J.); Siemens Healthcare NV/SA, Groot-Bijgaarden, Belgium (C.S., T.J.); Department of Radiology, Antwerp University Hospital, Antwerp, Belgium (F.B., F.V., A.S., P.V.D.); and MIRA, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium (A.S., P.V.D.).
Article Synopsis
- - The study aimed to assess the effectiveness of advanced deep learning techniques in speeding up knee MRI scans while maintaining image quality and diagnostic accuracy, comparing a new 4-fold accelerated protocol and a 3D superresolution reconstruction against a standard 2-fold accelerated method.
- - Researchers conducted MRI scans on 19 adult participants using three different protocols in a single session, resulting in over 21,000 images that were evaluated for quality and diagnostic confidence by three readers, including two specialized radiologists.
- - Statistical analysis was performed to compare the protocols, focusing on image quality and the detection of knee injuries, with the outcomes assessed using Likert scales for both anatomical visibility and confidence in diagnosis.