1 results match your criteria: "Investigation Center of Clinical Biochemistry and Immunology (CIBICI-CONICET)[Affiliation]"
Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells.
Anticancer Drugs
August 2014
aDr Fernando Cañas Lab, Biochemistry and Molecular Biology, School of Medicine, National Research Institute of Health Science (INICSA), National Research Council of Science and Technology (CONICET), National University of Córdoba (UNC) bClinical Biochemistry, Investigation Center of Clinical Biochemistry and Immunology (CIBICI-CONICET), Chemistry Faculty, UNC, Córdoba, Argentina.
The prognosis and incidence of colon cancer are linked to vitamin D3 serum levels. To evaluate the effects of D,L-buthionine-S,R-sulfoximine (BSO), 1,25(OH)2D3 and their combination on intestinal Caco-2 cell growth, to elucidate the possible cellular mechanisms involved in their antiproliferative action, and to determine whether BSO acts as a sensitizer to 1,25(OH)2D3 treatment, enabling minimization of the toxic effects caused by high doses of the steroid. Human colon cancer Caco-2 cells were treated with 1,25(OH)2D3, BSO, both, or vehicle.
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