2,463 results match your criteria: "Intra-abdominal Sepsis"
The effect of minimally invasive surgery on thirty-day postoperative outcomes of frail patients undergoing emergency colon resections.
Surgery
December 2024
Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:
Background: Frail patients have poor outcomes after emergent colon surgery. While minimally invasive surgery has shown improved outcomes in the general patient population undergoing colectomy, the benefits in frail patients are unknown.
Methods: We identified frail patients who underwent urgent or emergent colon resections from 2017 to 2021 in the National Surgical Quality Improvement Program database.
Enterococcus avium Infection After Liver Transplantation in Vietnam: A Case Report.
Transplant Proc
December 2024
Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoi, Vietnam. Electronic address:
Background: The infectious complications are the most common and can be life-threatening to liver transplant recipients, in particular, within the first month after transplantation. Early diagnosis of these severe complications and accurate detection of causative etiologies are crucial for the choice of therapeutic strategies and management of liver transplants.
Case Report: We present a case report of a patient with a history of primary sclerosing cholangitis who underwent a liver transplantation (LT) from a living donor.
[Clinical characteristics and risk factors for adverse outcomes in omphalocele].
Zhonghua Er Ke Za Zhi
December 2024
Departement of Neonatal Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, Hangzhou310052, China.
To investigate the clinical characteristics of omphalocele, and to assess the risk factors associated with adverse outcomes. A retrospective cohort study was conducted. Clinical data of 224 patients diagnosed with omphalocele, who were hospitalized at Children's Hospital, Zhejiang University School of Medicine from January 2013 to December 2022, were collected.
View Article and Find Full Text PDFPreventive effect of probiotics on infections following colorectal cancer surgery: An umbrella meta-analysis.
World J Gastrointest Surg
November 2024
Department of Gastrointestinal Surgery, Shandong Provincial Third Hospital, Shandong University, Jinan 250031, Shandong Province, China.
Background: Postoperative infections remain a significant source of morbidity among patients undergoing colorectal cancer (CRC) surgery. While probiotics have been proposed as a potential strategy to mitigate the risk of these infections, contemporary meta-analyses have produced conflicting findings.
Aim: To synthesize the available evidence regarding the prophylactic efficacy of probiotics in preventing infections following CRC surgery.
Intestinal epithelial-specific occludin deletion worsens gut permeability and survival following sepsis.
Shock
December 2024
Department of Surgery and Emory Critical Care Center, Emory University, School of Medicine, Atlanta, Georgia, USA.
Article Synopsis
- - Sepsis leads to increased intestinal permeability, which is linked to higher mortality rates; occludin, a tight junction protein, is crucial for maintaining the intestinal barrier.
- - Research comparing occludin knockout mice and wild-type controls demonstrated that occludin KOIEC mice experienced significantly increased intestinal permeability only under septic conditions, without changes in other permeability pathways.
- - The occludin-deficient mice showed elevated inflammatory cytokines and higher mortality rates after sepsis, highlighting occludin's essential role in gut barrier function and survival, suggesting potential therapeutic approaches to enhance occludin function in sepsis treatment.
Risk factors for anastomotic complications after elective intestinal resection in Crohn's disease.
Turk J Surg
June 2024
Department of General Surgery, Marmara University Faculty of Medicine, İstanbul, Türkiye.
Article Synopsis
Cefiderocol in the Successful Treatment of Complicated Hospital-Acquired K. pneumoniae NDM, OXA48 Intraabdominal Infection.
Infect Drug Resist
November 2024
Department and Clinic of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland.
Background: MDR/XDR constitutes a difficult to treat bacteria in a number of infections as there are few therapeutic options. Promising drugs in such cases can be cefiderocol, aztreonam and ceftazidime/avibactam or meropenem/vaborbactam.
Case Presentation: A 72-year-old female patient with sepsis caused by KP NDM, OXA 48 was admitted to the Intensive Care Unit, immediately after an emergency graftectomy (of a recently transplanted kidney) complicated with bleeding.
Prenatal Ultrasound Markers of Adverse Perinatal Outcomes in Newborns With Simple and Complex Gastroschisis.
J Clin Ultrasound
November 2024
Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil.
Objective: The aim of this study was to compare prenatal ultrasound markers and perinatal outcomes in newborns with simple and complex gastroschisis.
Methods: A retrospective cohort study was performed on pregnant women with gastroschisis fetuses and their respective newborns between 2009 and 2019. Binary logistic regression was used to determine the best prenatal ultrasound markers of complex gastroschisis and adverse perinatal outcomes.
Advancing perioperative optimization in Crohn's disease surgery with machine learning predictions.
World J Gastrointest Surg
October 2024
Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples 80131, Italy.
This editorial offers commentary on the article which aimed to forecast the likelihood of short-term major postoperative complications (Clavien-Dindo grade ≥ III), including anastomotic fistula, intra-abdominal sepsis, bleeding, and intestinal obstruction within 30 days, as well as prolonged hospital stays following ileocecal resection in patients with Crohn's disease (CD). This prediction relied on a machine learning (ML) model trained on a cohort that integrated a nomogram predictive model derived from logistic regression analysis and a random forest (RF) model. Both the nomogram and RF showed good performance, with the RF model demonstrating superior predictive ability.
View Article and Find Full Text PDFNeonatal Liver Imaging: Techniques, Role of Imaging, and Indications.
Radiographics
December 2024
From the Department of Diagnostic and Interventional Radiology (F.H., C.R., G.B.C.), Department of Pediatric Laboratory Medicine, Division of Pathology (I.S.), and Division of Neonatology (C.T.), The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8; and Departments of Medical Imaging (F.H., C.R., G.B.C.), Laboratory Medicine and Pathobiology (I.S.), and Pediatrics (C.T.), University of Toronto, Toronto, Ontario, Canada.
The neonatal liver may be affected by a variety of congenital and acquired diseases. Imaging has an important role in the workup and management of many neonatal hepatic abnormalities. Some aspects of imaging the liver and imaging findings are specific to neonatal patients when compared with those in older children.
View Article and Find Full Text PDFKey Aspects of Pediatric Liver Transplant Patient Visits to the Pediatric Emergency Department.
Exp Clin Transplant
October 2024
From the Department of Pediatrics, Division of Pediatric Emergency Medicine, Baskent University Medical Faculty, Ankara, Turkey.
Objectives: Patients with liver transplant can present to a pediatric emergency department with short- and long-term complications of transplant. Here, we described clinical features of pediatric liver transplant patients admitted to the pediatric emergency department and identified risk factors that may lead to pediatric intensive care unit admission.
Materials And Methods: We retrospectively evaluated pediatric liver transplant patients admitted posttransplant to Baskent University Hospital's pediatric emergency department in 2023.
Comparison of three different methods for stump closure in laparoscopic appendectomy: Endoloop, Hem-o-lok clip, and endostapler.
Ulus Travma Acil Cerrahi Derg
November 2024
Department of General Surgery, Istanbul University- Cerrahpasa Cerrahpasa Medical Faculty, İstanbul-Türkiye.
Article Synopsis
- * The study analyzed 150 patients who underwent laparoscopic appendectomy to compare the effectiveness and safety of three stump closure methods: endoloop, Hem-o-lok clips, and endostaplers.
- * Results showed that 96% of patients experienced no major complications, while the remaining 4% had issues, indicating that all three closure methods can be effective, though more research is needed on the best approach.
[Laparoscopic surgery for advanced peritonitis].
Khirurgiia (Mosk)
October 2024
People's Friendship University of Russia, Moscow, Russia.
Article Synopsis
- The study aimed to establish criteria for selecting surgical access methods in patients with advanced peritonitis, analyzing 588 cases linked to conditions like appendicitis and ulcers.* -
- Treatment outcomes were evaluated using several scoring systems (MPI, SPP, WSES SSS), highlighting that laparotomy is recommended under specific score conditions but is contraindicated in certain severe cases.* -
- Ultimately, the decision for the surgical approach relies on careful patient evaluation, the surgeon's experience, and proficiency in laparoscopic techniques to enhance the use of minimally invasive surgery in emergencies.*
Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia.
Microbiome
October 2024
Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Article Synopsis
- * The study involved 50 postmenopausal women, divided into low and high visceral adiposity tissue (VAT) groups, assessing dietary intake, plasma endotoxemia markers, and gut microbiome through various tests.
- * Results indicated that women with high VAT had a higher abundance of Proteobacteria, increased LBP levels, and elevated LPS-expressing bacteria, suggesting a link between gut bacteria, inflammation, and obesity.
Epidemiology and timing of infectious complications from battlefield-related burn injuries.
Burns
December 2024
Infectious Disease Service, Brooke Army Medical Center, 3551 Roger Brooke Drive, JBSA Fort Sam Houston, TX 78234, United States.
Article Synopsis
- Infections are a major complication in burn patients, particularly among U.S. military personnel who sustained injuries in Iraq and Afghanistan from 2009 to 2014, with 18% of the studied patients developing infections.
- The most common initial infection was pneumonia, occurring within four days post-injury, while those with infections had more severe burns, longer time before surgical treatment, and higher rates of inhalation injury.
- The research indicates that military personnel with burn injuries face significant risks for serious infections, with a notable percentage suffering from multidrug-resistant Gram-negative bacteria and a concerning mortality rate among those with multiple infections.
The Management and Outcomes of Septic Shock Among Surgical Patients at the Jimma University Medical Center, Jimma, Ethiopia: A Prospective Study.
Cureus
August 2024
Department of surgery, College of Public Health and Medical Sciences, Jimma University, Jimma, ETH.
Article Synopsis
- * A study at Jimma University Medical Centre in Ethiopia from April to October 2023 included 61 surgical patients with septic shock, where the majority were male, and common infection sources included community-acquired and intra-abdominal infections.
- * The findings revealed an alarming 30-day mortality rate of 80.3%, with most patients undergoing surgery for source control within 24 hours, highlighting a significant gap in adherence to recommended septic shock management practices.
A case of an intraabdominal, but extrahepatic ruptured percutaneous transhepatic biliary drainage and its following rescue. A case report and literature review.
Radiol Case Rep
November 2024
Department of Diagnostic and Interventional Radiology, Sana Klinikum Hof GmbH, Hof, Germany.
Article Synopsis
- Percutaneous transhepatic biliary drainage is a crucial treatment for biliary obstruction, especially when endoscopic methods fail, as demonstrated in an 82-year-old man with cholangiocarcinoma.
- After initial success with the drainage procedure, complications arose due to accidental dislodgement of the drain, resulting in biliary peritonitis and worsening health.
- The extractive procedure to remove the fractured drain highlighted the significance of interventional radiology in addressing complications, and a new technique was developed to ensure better fixation and prevent future dislodgements.
An Uncommon Consequence of Perforated Acute Appendicitis in Elderly Patients: Fournier's Gangrene.
Cureus
August 2024
General and Colorectal Surgery, Glan Clwyd Hospital, Rhyl, GBR.
Article Synopsis
- Untreated acute appendicitis can lead to serious complications like necrotizing fasciitis, especially in older patients.
- A 77-year-old man developed Fournier's gangrene due to a perforated appendix, despite not showing typical symptoms initially.
- This case emphasizes the importance of recognizing atypical symptoms in elderly patients and the need for prompt surgical treatment to prevent severe infections.
Severe acute pancreatitis complicated with intra-abdominal infection secondary to trauma: A case report.
World J Clin Cases
September 2024
Department of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin 300100, China.
Article Synopsis
- - Pancreatic trauma (PT) is a rare but serious injury linked to high mortality rates, often leading to complications like acute pancreatitis (AP) and sepsis, which worsen patient outcomes.
- - A 25-year-old patient experienced multiple organ injuries, including PT, after an abdominal trauma that led to necrotising pancreatitis following an emergency caesarean section, compounded by intra-abdominal infection.
- - The patient's treatment involved both conservative measures, like antibiotics and fluid support, and surgical interventions such as drainage and tissue debridement, which resulted in improved health outcomes.
Infectious Foci, Comorbidities and Its Influence on the Outcomes of Septic Critically Ill Patients.
Microorganisms
August 2024
Unidade Cuidados Intensivos, Unidade Local de Saúde Estuário do Tejo, 2600-009 Vila Franca de Xira, Portugal.
Article Synopsis
- - Sepsis is a common reason for ICU admissions, primarily caused by uncontrolled infections leading to serious health issues like hypoperfusion and organ failure, often resulting in septic shock.
- - A study at Hospital de Vila Franca de Xira from 2017 to 2023 found that 32.2% of ICU patients had sepsis upon admission, with the lung being the most common source of infection; 37.9% of these patients were in septic shock, which was linked to higher hospital mortality.
- - Infections from lung, skin, and peritonitis had poorer outcomes, while urinary and biliary tract infections showed better one-year survival rates, indicating the importance of the infection source on patient prognosis.
Rotational Thromboelastometric Profile in Early Sepsis: A Prospective Cohort Study.
Biomedicines
August 2024
Department of Anesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Article Synopsis
- Sepsis patients often experience coagulation problems, leading to higher mortality rates; this study used ROTEM to evaluate their hemostatic profile.
- The research involved 78 sepsis patients admitted to an ICU, finding significant differences in ROTEM parameters between those who survived and those who did not.
- Key findings indicated that non-survivors had lower fibrinolytic activity, and a model that included various ROTEM parameters effectively predicted short-term mortality in sepsis cases.*
Source Control and Antibiotics in Intra-Abdominal Infections.
Antibiotics (Basel)
August 2024
General, Emergency and Trauma Surgery Department, Bufalini Hospital, 47521 Cesena, Italy.
Article Synopsis
- - IAIs (intra-abdominal infections) are a leading cause of serious illness and death, especially in sepsis cases, with high hospital mortality rates (23-38%); timely identification and treatment are essential for better outcomes.
- - Effective management involves source control, which includes various procedures such as surgery, drainage, and debridement to remove the infection source and restore function, alongside early clinical evaluation and the use of prognostic scores to assess severity.
- - Rising antibiotic resistance poses a major global health challenge, highlighting the importance of appropriate antibiotic use, infection control measures, and adherence to guidelines in surgical departments to improve patient outcomes.
eHealth and mHealth in Antimicrobial Stewardship to Reduce Mortality in Empirical Antimicrobial Therapy and a Systematic Review with a Meta-Analysis of Adequate Therapy.
Infect Dis Rep
August 2024
Laboratory of Emerging Infectious Diseases, Pontifícia Universidade Católica do Paraná, Curitiba 80215-901, Brazil.
Article Synopsis
- The study highlights the need for quicker diagnostic methods to identify pathogens and test for antimicrobial resistance due to increasing bacterial resistance and limited treatment options, especially in sepsis cases.
- Advances in rapid molecular and mass spectrometry techniques have improved turnaround times for test results, leading to better patient outcomes.
- The systematic review and meta-analysis show that inadequate empirical antimicrobial therapy is linked to higher mortality rates, making faster pathogen identification technologies crucial for reducing mortality.
Evaluating a novel vertical traction device for early closure in open abdomen management: a consecutive case series.
Front Surg
August 2024
Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, Aachen, Germany.
Article Synopsis
- - The study explores the effectiveness of a new device called the vertical traction device (VTD) in facilitating early definitive fascial closure (DFC) for patients with an open abdomen due to abdominal compartment syndrome (ACS).
- - Out of nine patients who were treated, six successfully achieved DFC, with the VTD significantly reducing the distance between fascia until closure, while not impacting ventilation or other critical health metrics adversely.
- - Although three patients died before DFC and some experienced mild skin irritation, the study concludes that the VTD is a promising and safe tool for improving outcomes in emergency surgical cases involving open abdomens.
A case report of iliopsoas abscess and literature review.
Medicine (Baltimore)
August 2024
Intensive Care Unit, Guangdong Provincial People's Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai), Zhuhai, China.
Article Synopsis
- - Iliopsoas abscess is a rare condition typically caused by infections spreading from nearby structures, presenting symptoms like fever, back pain, and leg weakness; it requires quick medical attention to prevent sepsis.
- - A 65-year-old male patient experienced worsening symptoms, including fever and delirium, and was found to have bilateral iliopsoas abscesses and infection linked to vegetation on the aortic valve.
- - After treatment involving antibiotics and surgical drainage, the patient's condition improved, emphasizing the importance of early diagnosis and intervention to enhance recovery outcomes.