3,446 results match your criteria: "Intestinal Stromal Tumors"
Differential diagnosis of submucosal gastric tumors: gastric schwannomas misdiagnosed as GISTs.
J Surg Case Rep
December 2024
Department of Pathology, İzmir University of Economics, Fevzi Çakmak, Sakarya Cd. No. 156, 35330 Balçova/İzmir, Türkiye.
Schwannomas commonly occur in the head and neck region but are rarely seen in the gastrointestinal tract; the stomach and small intestine are the most commonly involved sites. These tumors are usually misdiagnosed as gastrointestinal stromal tumors (GISTs) before histopathological confirmation due to radiological similarity. GI schwannomas show positivity for S100 protein and vimentin but are negative for CD 117 and CD 34, which helps in differentiating the tumor from GISTs.
View Article and Find Full Text PDFImpact of Gastrointestinal Bleeding on Prognosis and Associated Risk Factors in Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis.
Am Surg
December 2024
Department of Gastrointestinal Surgery, The First Hospital of China Medical University, Shenyang, China.
Background: Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors of the digestive tract. The impact of gastrointestinal bleeding on the prognosis of GISTs remains controversial. This study aims to evaluate the prognostic significance of gastrointestinal bleeding in GIST patients and analyze associated risk factors.
View Article and Find Full Text PDFDifferent radiomics models in predicting the malignant potential of small intestinal stromal tumors.
Eur J Radiol Open
December 2024
Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Objectives: To explore the feasibility of different radiomics models for predicting the malignant potential of small intestinal stromal tumors (SISTs), and to select the best radiomics model.
Methods: A retrospective analysis of 140 patients with SISTs was conducted. Radiomics features were extracted from CT-enhanced images.
Characteristics and prognosis of small bowel tumors: A retrospective study.
World J Clin Cases
December 2024
Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Background: Small bowel tumors (SBTs) are a heterogeneous group of difficult-to-diagnose tumors that account for 2%-5% of all gastrointestinal tumors. Single-balloon enteroscopy greatly enhances the diagnosis and treatment of SBTs. However, few epidemiological studies have been conducted in Taiwan to determine the clinical profile of SBTs.
View Article and Find Full Text PDFPrevotellaceae Modulates Colorectal Cancer Immune Microenvironment to Assist Anti-PD-L1 Immunotherapy.
Turk J Gastroenterol
November 2024
Department of General Surgery, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China.
Background/aims: Colorectal cancer (CRC) stands as the third most prevalent cancer on a global scale. In recent years, immunotherapy, such as anti-PD-L1 treatment, has demonstrated promising therapeutic outcomes in CRC. However, studies have suggested that intestinal microbiota may influence the efficacy of anti-PD-L1 immunotherapy.
View Article and Find Full Text PDFPathologic diagnosis and molecular features of gastrointestinal stromal tumors: a mini-review.
Front Oncol
November 2024
Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Article Synopsis
- * About 80% of GISTs have mutations in KIT or PDGFRA that affect how they behave and respond to treatment; a special type called SDH-deficient GISTs is linked to certain genetic syndromes and presents different challenges.
- * The primary treatment involves surgery and the drug imatinib for advanced cases, but resistance to treatment is a major issue, particularly in kids and wildtype GISTs, highlighting the need for better therapies and personalized treatment approaches.
Primary Small Intestinal Leiomyosarcoma Presenting With Small Bowel Perforation: A Case Report.
Cureus
November 2024
Department of General Surgery, University Hospitals Dorset NHS Foundation Trust, Bournemouth, GBR.
Article Synopsis
- - A 75-year-old woman with abdominal pain and elevated inflammatory markers had a CT scan that revealed a perforated mass in her small intestine, leading to surgery and the discovery of a small intestinal leiomyosarcoma (LMS) after initial suspicion of a gastrointestinal stromal tumor (GIST).
- - The diagnosis of LMS is challenging and can often be misclassified as GIST due to similar features; imaging studies like CT can help but are not always conclusive.
- - This case emphasizes the importance of recognizing LMS as a potential cause of bowel perforation, highlighting the need for accurate diagnosis, multidisciplinary management, and long-term follow-up due to the high risk of recurrence and metastasis.
Intratumoral Bacteria are Uncommon in Gastrointestinal Stromal Tumor.
Ann Surg Oncol
November 2024
Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are the most prevalent type of sarcoma in humans, predominantly occurring in the stomach or small intestine, with over 5000 new cases diagnosed annually in the USA.
- A study investigated the presence of bacteria within GISTs by analyzing 25 tumor samples from 24 patients using advanced genetic sequencing techniques.
- Results showed that most samples had negligible bacterial presence, while two samples indicated normal intestinal bacteria, but only in tumors where the mucosal lining was disrupted.
[Prognosis and its influencing factors in patients with non-gastric gastrointestinal stromal tumors at low risk of recurrence: a retrospective multicenter study in China].
Zhonghua Wei Chang Wai Ke Za Zhi
November 2024
Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai200127,China.
Article Synopsis
- This study aimed to analyze the prognosis and influencing factors for patients with non-gastric gastrointestinal stromal tumors (GISTs) classified as low risk for recurrence, gathering data from 1,571 patients across 18 medical centers in China from 2000 to 2023.
- Among the participants, 23.6% were at very low risk and 76.4% at low risk, with a median follow-up of 63 months showing high overall survival (99.5% at 5 years) and disease-free survival rates (96.3% at 5 years).
- The findings highlighted that 3.8% of patients experienced disease recurrence, mostly within the low-risk group, with variances
Mapping and tracing Grem1 stromal cells in an mouse utilizing cryopreserved intestinal sections prepared via modified Swiss-roll technique.
iScience
November 2024
Tomas Lindahl Nobel Laureate Laboratory, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China.
Article Synopsis
- Grem1 cancer-associated fibroblasts (CAFs) play a vital role in the development of colorectal cancer (CRC), but their origins and functions have been difficult to study due to technical limitations.
- * The research used an optimized gut Swiss-roll technique to create single cryopreserved slides, revealing a significant increase in Grem1 CAFs in tumor tissues compared to normal mucosa at 12 weeks.
- * Lineage tracing showed that most Grem1 CAFs in the tumor core derived from Grem1 intestinal reticular stem cells (iRSCs), indicating their potential as a key target for early CRC therapies, while a smaller subset came from Grem1 intestinal sub-epithelial myofibroblasts
Optimizing Outcomes in Gastrointestinal Stromal Tumors: A Surgeon's Perspective.
Cureus
October 2024
Trauma and Acute Care Surgery, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Article Synopsis
- * Surgical resection is the primary treatment for localized GISTs, and it's crucial to avoid rupturing the tumor during the procedure to prevent complications like peritoneal spread.
- * In addition to surgery, tyrosine kinase inhibitors, such as imatinib, play a key role in the management of GISTs, especially in advanced cases, and patients require long-term monitoring for potential recurrences.
An additional gastrojejunostomy may reduce the incidence of moderate and severe delayed gastric emptying after distal segmental duodenectomy for gastrointestinal stromal tumors.
World J Surg Oncol
November 2024
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Sarcoma Center, Peking University Cancer Hospital & Institute, Beijing, China.
Article Synopsis
- * Out of 50 patients, those who had bypass surgery (with gastrojejunostomy) experienced significantly less grade B-C DGE compared to those who didn't, suggesting the bypass may be beneficial.
- * Although the bypass group showed a trend towards shorter hospital stays, the difference wasn’t statistically significant, indicating further research is needed on the overall benefits of the gastrojejunostomy procedure.
Appendiceal neurofibroma after resection of multiple gastrointestinal stromal tumors of the small intestine in a patient with neurofibromatosis type 1: a case report.
Surg Case Rep
November 2024
Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
Article Synopsis
- * A 68-year-old man with NF1 had multiple small intestinal GISTs causing anemia and underwent surgery to remove them; two years later, he developed an enlarging mass in the appendix that was surgically removed due to concerns about its potential malignancy.
- * Post-surgery, the diagnosis of an appendiceal neurofibroma was confirmed, highlighting the challenge in identifying these lesions preoperatively and stressing the importance of surgical
Surgical Management of Gastric Gastrointestinal Stromal Tumors.
Surg Clin North Am
February 2025
Division of Surgical Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, East/Shapiro 3, Boston, MA 02215, USA. Electronic address:
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are a type of sarcoma found in the muscular layer of the gastrointestinal tract, primarily occurring in the stomach and small intestine.
- The main treatment is surgical resection, with various techniques available, though extensive surgical measures like lymphadenectomy are usually not needed.
- Tyrosine kinase inhibitors can be used before surgery to shrink tumors and after surgery for high-risk cases, and in some instances, removing metastases can enhance patient outcomes.
GIST-ery solved: story of an intestinal mass in a young lady.
J Surg Case Rep
November 2024
Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal 576 104, Karnataka, India.
Article Synopsis
- * Surgery revealed a different type of tumor, identified as a calcifying fibrous tumor (CFT), after immunohistochemical tests showed no GIST markers.
- * The case emphasizes the need for detailed diagnostic evaluations and histopathological assessments to accurately differentiate between tumor types, ensuring proper treatment and care.
Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells.
iScience
October 2024
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan.
Article Synopsis
- The study focuses on using human induced pluripotent stem cell-derived colon organoids (hiPSC-COs) to develop a reliable model of inflammatory bowel disease (IBD), which is important for understanding the condition and creating better treatments.
- Researchers treated these organoids with three cytokines (TNF-α, IFN-γ, IL-1β) that are known to be elevated in IBD patients, resulting in both inflammation in supportive cells and damage to the intestinal lining.
- The study found that the molecular profile of the treated organoids closely matched that of ulcerative colitis patients, and treatment with a drug called tofacitinib reduced inflammation, showing promise for further research into UC therapies.
Article Synopsis
- Laparoscopic sleeve gastrectomy (LSG) is a common weight-loss surgery, and this study examines the value of routinely sending removed stomach tissue for histopathological analysis over a five-year period.
- The research involved a retrospective analysis of 203 patients, mostly female, to assess their demographics, preoperative procedures, and histopathological results, revealing that 81.3% had normal gastric mucosa and only a small fraction had clinically significant findings.
- The study concludes that since most specimens showed non-significant results and no patients required further treatment, the routine practice of histopathological examination after LSG may need reevaluation.
Routine Histopathology in Laparoscopic Sleeve Gastrectomy Over 10 Years.
Cureus
September 2024
General Surgery, Shifa International Hospital, Islamabad, PAK.
Article Synopsis
- Laparoscopic sleeve gastrectomy (LSG) is a popular bariatric surgery, and a study was conducted to examine the histopathology of specimens from 538 LSG cases over ten years at Shifa International Hospital in Pakistan.
- The majority of cases showed gastritis (80.5%), with 26% of specimens exhibiting infection, while there were few other notable findings like intestinal metaplasia and two tumors linked to gastritis.
- There were no significant differences in the prevalence of gastritis or infection based on age or gender, highlighting the common occurrence of gastric changes in morbidly obese patients undergoing LSG.
Proximal jejunal GIST associated with massive gastrointestinal bleeding. Case report.
Cir Cir
October 2024
Departamento de Medicina Interna, Hospital General Regional Dr. Manuel Cárdenas de la Vega, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Culiacán, Sinaloa. México.
Article Synopsis
- Gastrointestinal stromal tumors (GIST) are rare tumors affecting about 10 to 15 people per million, primarily found in the stomach and small intestine, and may present symptoms like nausea and abdominal fullness, although 30% are asymptomatic.
- The standard treatment for GIST is surgical resection with negative margins.
- A case report describes a 69-year-old woman who experienced severe digestive tract bleeding, leading to the discovery of a GIST in her jejunum during surgery.*
Duodeno-duodenal intussusception due to gastrointestinal stromal tumor: A case report.
SAGE Open Med Case Rep
September 2024
Central Radiology Department, Ibn Sina University Hospital of Rabat, Morocco.
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are common tumors in the gastrointestinal tract, mostly found in the stomach (60%-70%) and small intestine (20%-30%), primarily affecting individuals over 50 years old.
- They often present vague symptoms, making diagnosis difficult, which requires advanced imaging techniques like CT and MRI for accurate assessment.
- Treatment typically involves surgery and targeted therapy, and the case of a 77-year-old woman highlights rare complications like intussusception related to GISTs, enhancing understanding of these tumors' varied presentations.
Isolated liver gastrointestinal stromal tumor: A case report.
J Clin Ultrasound
October 2024
Department of Ultrasound in Medicine, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, China.
Article Synopsis
- A case study detailed a 38-year-old man with multiple cystic-solid liver lesions, ultimately diagnosed as a liver GIST after a CT-guided biopsy, but distinguishing between PLGIST and LMGIST was complicated due to missing medical history.
- The study emphasizes the importance of understanding this rare liver tumor type for better diagnosis and staging, especially as the lesions increased in size during a two-year follow-up without any other lesions found outside the liver.
Article Synopsis
- - GISTs (Gastrointestinal stromal tumors) are the most common type of tumors found in the GI tract, usually located in the stomach and small intestine, and can be classified into spindle cell, epithelioid, and mixed types.
- - A case study described a 23-year-old female with a large intra-abdominal mass who experienced symptoms like dysphagia and early satiety for a year before seeking medical help.
- - The diagnosis of her significant left retroperitoneal mass, measured at 17 × 12 × 21 cm, necessitated surgical intervention, highlighting the need for awareness of such rare tumors in young adults.
Exploring the constitutive activation mechanism of the class A orphan GPR20.
Acta Pharmacol Sin
September 2024
Key Laboratory of Protection, Development and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Peptide & Protein Drug Research Center, School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
Article Synopsis
- GPR20 is an orphan G protein-coupled receptor that is highly expressed in intestinal tissue and may serve as a therapeutic target for gastrointestinal stromal tumors.
- This study investigates the mechanism of GPR20's constitutive activation using large-scale molecular dynamics simulations, revealing the involvement of allosteric signal transduction across different domains of the receptor.
- Findings indicate that both the N-terminal cap of GPR20 and G protein are essential for its active state, with the N-terminal cap acting like an agonist to enable conformational changes, thus advancing understanding for drug development targeting GPR20.
Article Synopsis
- Ultra-high dose rate FLASH radiotherapy shows promise in reducing toxicity to normal tissues compared to standard proton radiotherapy while maintaining effective anti-tumor responses.
- Research demonstrated that FLASH treatment led to faster recovery and improved survival in mice after whole-abdomen irradiation, linked to enhanced proliferation of stem and progenitor cells for tissue regeneration.
- The benefits of FLASH are attributed to changes in immune and stromal cell signaling, particularly involving TGF-β and IFN-I pathways, which differ significantly from those activated in standard radiotherapy, thus minimizing side effects.
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
Cell Signal
November 2024
Department of Immunology, Binzhou Medical University, Yantai, 264000, Shandong Province, China. Electronic address:
Article Synopsis
- Human placental mesenchymal stromal cells (hPMSCs) help reduce intestinal damage in graft-versus-host disease (GVHD) by decreasing oxidative stress and improving tight junction protein expression.
- In experiments with GVHD mice and TNF-α-stimulated human colon cells, hPMSCs demonstrated a reduction in harmful substances and an increase in protective enzymes.
- The mechanisms behind hPMSCs' protective effects are linked to a specific signaling pathway involving CD73, adenosine, and several key proteins that regulate oxidative stress and cell integrity.