1,077 results match your criteria: "Intestinal Leiomyosarcoma"

Article Synopsis
  • - A 75-year-old woman with abdominal pain and elevated inflammatory markers had a CT scan that revealed a perforated mass in her small intestine, leading to surgery and the discovery of a small intestinal leiomyosarcoma (LMS) after initial suspicion of a gastrointestinal stromal tumor (GIST).
  • - The diagnosis of LMS is challenging and can often be misclassified as GIST due to similar features; imaging studies like CT can help but are not always conclusive.
  • - This case emphasizes the importance of recognizing LMS as a potential cause of bowel perforation, highlighting the need for accurate diagnosis, multidisciplinary management, and long-term follow-up due to the high risk of recurrence and metastasis.
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Article Synopsis
  • Primary atopic disorders (PAD) are rare genetic conditions caused by specific gene variants that affect skin and immune function, making diagnosis challenging among common allergic disease cases.
  • Identifying PAD requires recognizing clinical red flags like family history and unusual infections, as conventional lab tests are inadequate for definitive diagnosis.
  • Whole-genome sequencing (WGS) enhances diagnostic efficiency and accuracy, but requires careful interpretation and collaboration among specialists to effectively manage PAD cases.
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Article Synopsis
  • Gastrointestinal stromal tumors (GISTs) are common tumors in the gastrointestinal tract, mostly found in the stomach (60%-70%) and small intestine (20%-30%), primarily affecting individuals over 50 years old.
  • They often present vague symptoms, making diagnosis difficult, which requires advanced imaging techniques like CT and MRI for accurate assessment.
  • Treatment typically involves surgery and targeted therapy, and the case of a 77-year-old woman highlights rare complications like intussusception related to GISTs, enhancing understanding of these tumors' varied presentations.
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Ascending Colon Leiomyoma: A Case Report of a Uncommon Case.

J Pharm Bioallied Sci

July 2024

Department of Internal Medicine, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Article Synopsis
  • Gastrointestinal smooth muscle tumors, particularly leiomyomas, are rare in the colon and mostly benign, often found in middle-aged and older adults.
  • A case report describes a 52-year-old man who had a 5-mm polyp in the ascending colon, which was diagnosed as an inflamed submucosal leiomyoma after removal and histopathological examination.
  • Although benign, diagnosing intestinal leiomyoma can be challenging due to its resemblance to other tumors, and while imaging can help, definitive diagnosis usually requires a tissue examination; treatment options include polypectomy and surgical excision.
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Article Synopsis
  • * The case presented involves a 23-year-old patient who experienced symptoms such as nausea, weight loss, abdominal pain, and iron deficiency anemia, ultimately diagnosed with leiomyosarcoma of the jejunum.
  • * The study highlights the importance of distinguishing between gastrointestinal stromal tumors (GISTs) and leiomyosarcoma using different types of evidence, stressing that an accurate diagnosis is crucial for effective treatment.
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Article Synopsis
  • The incidence of leiomyosarcoma (LMS) is rare, affecting about 4-5 individuals per 100,000 annually, with small bowel LMS being even more uncommon and challenging to diagnose preoperatively.
  • Two patients with confirmed small bowel LMS were analyzed for their clinical and imaging characteristics, along with a review of similar cases from the past decade.
  • LMS tumors were classified into three types based on their growth direction relative to the intestinal lumen, with intramural leiomyosarcoma emerging as a significant subtype; smaller tumor sizes and intraluminal types appear to have better prognoses, while extraluminal types are linked to worse outcomes.
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The patient was a 33-year-old female. She was referred to our hospital from a previous clinic with abdominal pain and vomiting. Contrast-enhanced abdominal CT revealed intussusception, leading to a diagnosis of intussusception with a small intestinal tumor as an advanced part.

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Background: Small intestinal leiomyosarcoma is a rare malignant tumor of the gastrointestinal tract. Clinical symptoms are atypical and can be complicated by gastrointestinal bleeding and intestinal obstruction.

Case Presentation: We report a case of a 73-year-old patient with small intestinal smooth muscle sarcoma with hepatic metastasis.

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Leiomyosarcomas (LMSs) are rare tumors originating from the muscular layer. We performed a literature review of cases of confirmed rectal leiomyosarcomas (rLMSs) to clarify the history of such an infrequent tumor arising at such an uncommon location. In this research local recurrence was related to poorly differentiated rLMS and no other association between recurrence and any criteria was found.

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Background: After a huge efficacy of imatinib in treating patients with gastrointestinal stromal tumors (GISTs) was proven, a maximum effort was made to make a differential diagnosis between GISTs and gastrointestinal leiomyosarcomas (GI-LMS), showing the latter to be an extremely rare tumor entity. Limited data on GI-LMS biology, clinical behavior and drug-sensibility are available, and the clinical decision-making in this subgroup of patients is usually challenging.

Methods: We conducted a multicenter, retrospective observational study on patients with diagnosed GI-LMS from 2004 to 2020 within six high-volume referral centers in Italy.

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Intra-abdominal leiomyosarcomas (LMSs) are aggressive malignant tumours arising from smooth muscle cells. These neoplasms are extremely rare and account for 10%-20% of primary soft tissue sarcomas and approximately 0.1% of all colorectal malignancies.

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Special features of sarcomas developed in patients with Lynch syndrome: A systematic review.

Crit Rev Oncol Hematol

August 2023

Department of Digestive Oncology, University Hospital of Toulouse (IUCT Rangueil Larrey), France; OncoSarc, INSERM U1037, Toulouse Cancer Research Center (CRCT), France. Electronic address:

Article Synopsis
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Gastrointestinal (GI) intestinal stromal tumors account for 60% of mesenchymal GI tract tumors commonly located in the stomach and small intestine, predominantly solid tumors that rarely undergo cystic degeneration. A 65-year-old patient with increasing upper abdominal swelling and a computed tomography scan abdomen showed a large unilocular 17 × 16 × 15 cm lesion. A colossal cystic swelling in the lesser omentum, anterior to the stomach, was found upon exploration.

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A 71-year-old male was diagnosed with gastric leiomyosarcoma in 2020 after biopsies of an ulcerated gastric lesion. Despite oncological treatment, he presented bone, liver and lung progression. Fourth line treatment with Pazopanib was started in 2022 with no evidence of intestinal or peritoneal metastases.

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Leiomyosarcoma of the lower rectum managed by radiotherapy and surgery: A case report and review of literature.

Cancer Radiother

May 2023

Department of oncology, 20, route du Vieux Séquoia, 1847 Rennaz, Switzerland.

Rectal leiomyosarcoma is a very rare entity. Surgery is the main treatment, but the place of radiation therapy remains unclear. A 67-year-old woman was referred for a few-weeks' history of bleeding and anal pain intensified during defecation.

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An improved understanding of the CT characteristics for histologically confirmed primary intestinal tumors would be helpful for guiding prognosis and treatment plans in affected dogs. This retrospective, multi-center, analytical study aimed to evaluate the CT characteristics for the differentiation of adenocarcinoma, lymphoma, and spindle cell sarcoma (SCS) in dogs. Thirty-seven dogs who underwent contrast CT and histopathological examinations were included (adenocarcinomas, n = 11; lymphomas, n = 12; SCS, n = 14).

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Primary ovarian leiomyosarcoma is a very uncommon and aggressive neoplasm. We presented a right-sided ovarian leiomyosarcoma in a woman in her late 40s. No case has been described in the literature till now of primary ovarian leiomyosarcoma in a woman with uterovaginal prolapse.

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Background: Low-grade endometrial stromal sarcoma (LGESS) classically exhibits a proliferative morphology. However, morphological variation of extrauterine tumors presents a diagnostic challenge.

Case Summary: We report the case of a 76-year-old female patient with extensive extrauterine and abdominal neoplastic lesions.

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