The role of neuroinflammation in the pathogenesis of glaucoma neurodegeneration.

The chapter is a review enclosed in the volume "Glaucoma: A pancitopatia of the retina and beyond." No cure exists for glaucoma. Knowledge on the molecular and cellular alterations underlying glaucoma neurodegeneration (GL-ND) includes innovative and path-breaking research on neuroinflammation and neuroprotection.

Tear 1H Nuclear Magnetic Resonance-Based Metabolomics Application to the Molecular Diagnosis of Aqueous Tear Deficiency and Meibomian Gland Dysfunction.

Purpose: Meibomian gland dysfunction (MGD) is a major cause of signs and symptoms related to dry eyes (DE) and eyelid inflammation. We investigated the composition of human tears by metabolomic approaches in patients with aqueous tear deficiency and MGD.

Methods: Participants in this prospective, case-control pilot study were split into patients with aqueous tear deficiency and MGD (DE-MGD [n = 15]) and healthy controls (CG; n = 20).

In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations.

Aims: A pre-operative non-invasive identification of the site of origin (SOO) of outflow tract ventricular arrhythmias (OTVAs) is important to properly plan radiofrequency ablation procedures. Although some algorithms based on electrocardiograms (ECGs) have been developed to predict left vs. right ventricular origins, their accuracy is still limited, especially in complex anatomies.

Comparison of the Physical Demands of Friendly Matches and Different Types On-Field Integrated Training Sessions in Professional Soccer Players.

The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS), SSG+CT+LSG (TS) and MG+CT+LSG (TS). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.

Cortisol levels and seizures in adults with epilepsy: A systematic review.

Stress has been suggested as a trigger factor for seizures in epilepsy patients, but little is known about cortisol levels, as indicators of stress, in adults with epilepsy. This systematic review summarizes the evidence on this topic. Following PRISMA guidelines, 38 articles were selected: 14 analyzing basal cortisol levels, eight examining antiepileptic drugs (AEDs) effects, 13 focused on seizure effects, and three examining stress.

Personality and Emotional Intelligence in Older Adults: A Predictive Model Based on Structural Equations Modeling.

Recent research on emotions in aging points to emotional intelligence (EI) as a factor that plays an important role in this process, and different conceptualizations of EI show that this construct is closely linked to personality in the general population. The main purpose of this study was to find out whether findings obtained in the general population indicating a predictive relationship between personality and EI are also confirmed during the aging process. A sample of 233 healthy older subjects between 60 and 90 years old was used.

Being an optimist or a pessimist and its relationship with morning cortisol release and past life review in healthy older people.

Objective: Investigate the relationship between optimism and pessimism and the cortisol awakening response (CAR) and past life review in healthy older people.

Design: 76 older volunteers summarised their lives, highlighting the most important events, impressions and experiences. Cortisol saliva samples were collected on two consecutive weekdays.