Developing Topics.

Background: Recent evidence suggests a potential link between systemic inflammation induced by viral infections like COVID-19 and the exacerbation of neurodegenerative processes in Alzheimer's disease (AD). This study aims to explore the novel idea that COVID-19 vaccines may offer neuroprotective effects against the progression of AD, leveraging machine learning techniques to analyze multimodal data sets.

Method: We conducted a retrospective cohort study involving 10,000 participants aged 65 and older, with an initial diagnosis of early-stage AD, from five distinct geographic locations.

Developing Topics.

Background: Emerging research indicates that autophagy, a cellular degradation process, may be triggered by certain immune responses, including those by vaccines. This study aims to examine whether the SARS-CoV-2 vaccines, known to induce robust immune activation, can trigger autophagic pathways that facilitate the degradation of amyloid-beta (Aβ), a pathological feature of Alzheimer's disease (AD). By applying deep learning techniques to analyze complex immunological and neurological data, this study explores a potentially innovative therapeutic strategy for AD.