Systematic Review on Chemsex: Advocating for Inclusive Research and Primary Prevention.

Chemsex is a specific practice of sexualized drug use (SDU), linked mainly to the group of men who have sex with men (MSM). This practice has become a public health problem due to the increase in sexually transmitted infections and HIV. However, there are groups and aspects that require greater visibility and research.

Dietary purslane (Portulaca oleracea L.) leaf powder maintains growth and intestinal health in Oreochromis niloticus under chronic water-borne cadmium exposure by strengthening the gut barriers, modulating the intestinal nutrient transporters, and relieving oxidative stress.

High cadmium (Cd) concentrations pose a threat to aquatic life globally. This study examined the efficiency of adding purslane (Portulaca oleracea L.) leaf powder (PLP) to Oreochromis niloticus diets on Cd's negative effects.

Didemnins as marine-derived anticancer agents: mechanistic insights and clinical potential.

Didemnins, a class of cyclic depsipeptides derived from marine organisms exhibit notable anticancer properties. Among them, Didemnin B has been extensively researched for its strong antitumor activity and progression to clinical trials. Nonetheless, its clinical application has been impeded by challenges like poor bioavailability and dose-limiting toxicity.

Missense variants weakening a SOX9 phosphodegron linked to odontogenesis defects, scoliosis and other skeletal features.

SOX9 encodes an SRY-related transcription factor critical for chondrogenesis and sex determination among other processes. Loss-of-function variants cause campomelic dysplasia and Pierre Robin Sequence, while both gain- and loss-of-function variants cause disorders of sex development. SOX9 has also been linked to scoliosis and cancers, but variants are undetermined.

Validation of an Eye-Foot Coordination Assessment Tool for Children in Dual-Task Condition.

: Eye-foot coordination is essential in sports and daily life, enabling the synchronization of vision and movement for tasks like ball control or crossing obstacles. This study aimed to examine both the validity and reliability of an innovative eye-foot coordination (EFC) test in a dual-task paradigm in children aged 6-11 years and the capacity of this test to discriminate between sex and age. : A total of 440 schoolchildren aged 6-11 years participated in this cross-sectional study.

Seasonal Land Use and Land Cover Mapping in South American Agricultural Watersheds Using Multisource Remote Sensing: The Case of Cuenca Laguna Merín, Uruguay.

Recent advancements in Earth Observation sensors, improved accessibility to imagery and the development of corresponding processing tools have significantly empowered researchers to extract insights from Multisource Remote Sensing. This study aims to use these technologies for mapping summer and winter Land Use/Land Cover features in Cuenca de la Laguna Merín, Uruguay, while comparing the performance of Random Forests, Support Vector Machines, and Gradient-Boosting Tree classifiers. The materials include Sentinel-2, Sentinel-1 and Shuttle Radar Topography Mission imagery, Google Earth Engine, training and validation datasets and quoted classifiers.

AllianceBlockchain in the Governance Innovation of Internet Hospitals.

The rise of Internet hospitals has significant issues associated with data security and governance in managing sensitive patient data. This paper discusses an alliance blockchain (i.e.

Real-Time PPG-Based Biometric Identification: Advancing Security with 2D Gram Matrices and Deep Learning Models.

The integration of liveness detection into biometric systems is crucial for countering spoofing attacks and enhancing security. This study investigates the efficacy of photoplethysmography (PPG) signals, which offer distinct advantages over traditional biometric techniques. PPG signals are non-invasive, inherently contain liveness information that is highly resistant to spoofing, and are cost-efficient, making them a superior alternative for biometric authentication.

A Narrative Review of the Assessment and Treatment of Physical Impairments Commonly Seen in Sarcoma Cancer Survivors Using a Rehabilitative Approach.

Background: Sarcomas are a rare, complex group of malignancies characterized by numerous clinical and pathological features. Sarcomas originate from various tissues such as fat, muscle, bone, nerves, blood vessels and connective tissues. Typically, the treatment of sarcomas consists of surgery, chemotherapy, and radiation therapy.

The Fetal Environment and the Development of Hypertension-The Epigenetic Modification by Glucocorticoids.

Intrauterine growth restriction (IUGR) is a risk factor for postnatal cardiovascular, metabolic, and psychiatric disorders. In most IUGR models, placental dysfunction that causes reduced 11β-hydroxysteroid dehydrogenase 2 (11βHSD2) activity, which degrades glucocorticoids (GCs) in the placenta, resulting in fetal GC overexposure. This overexposure to GCs continues to affect not only intrauterine fetal development itself, but also the metabolic status and neural activity in adulthood through epigenetic changes such as microRNA change, histone modification, and DNA methylation.

Genome Deletions and Rewiring of the Transcriptome Underlying High Antimonite Resistance in sp. SMAs-55.

Microbes have been shown to adapt to stressful or even lethal conditions through displaying genome plasticity. However, how bacteria utilize the ability of genomic plasticity to deal with high antimony (Sb) stress has remained unclear. In this study, the spontaneous mutant strain SMAs-55 of sp.

Dual-Double Stem Cell Ovarian Therapy: A Comprehensive Approach in Regenerative Medicine.

Dual-double stem cell therapy, which integrates mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), represents a cutting-edge approach in regenerative medicine, particularly for conditions such as ovarian decline, premature ovarian insufficiency (POI), and induced ovarian failure. This therapy leverages the unique properties of MSCs and HSCs, enhancing tissue repair, immune modulation, and overall regenerative outcomes. MSCs, known for their ability to differentiate into various cell types, provide a supportive microenvironment and secrete bioactive molecules that promote angiogenesis and reduce inflammation.

The Immunophenotype and the Odontogenic Commitment of Dental Pulp Stem Cells Co-Cultured with Macrophages Under Inflammatory Conditions Is Modulated by Complex Magnetic Fields.

Dental inflammatory diseases remain a challenging clinical issue, whose causes and development are still not fully understood. During dental caries, bacteria penetrate the tooth pulp, causing pulpitis. To prevent pulp necrosis, it is crucial to promote tissue repair by recruiting immune cells, such as macrophages, able to secrete signal molecules for the pulp microenvironment and thus to recruit dental pulp stem cells (DPSCs) in the damaged site.

SmartSkin-XAI: An Interpretable Deep Learning Approach for Enhanced Skin Cancer Diagnosis in Smart Healthcare.

Skin cancer, particularly melanoma, poses significant challenges due to the heterogeneity of skin images and the demand for accurate and interpretable diagnostic systems. Early detection and effective management are crucial for improving patient outcomes. Traditional AI models often struggle with balancing accuracy and interpretability, which are critical for clinical adoption.

Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review.

Fixed drug eruption (FDE) is a type of drug-induced skin inflammation characterized by the recurrence of lesions in the same region following repeated exposure to the causative drug. FDE typically presents as localized spots or plaques without systemic symptoms; however, it can manifest in other forms, such as blisters and papules. In FDE, effector memory CD8-positive T cells that remain dormant in the basal layer after a previous inflammation are reactivated upon re-exposure to the causative drug, leading to the development of erythema at the same sites.

Old Plants for New Food Products? The Diachronic Human Ecology of Wild Herbs in the Western Alps.

This ethnobotanical study examines the traditional knowledge and usage patterns of wild plants in the western Alps, specifically within the Ubaye and Bellino Valleys, through a comparative analysis of data collected from 1983 (published in 1990) to 2024. Our study aims to assess the change in plant usage, species diversity, and the changing roles of plants in local traditions in the western Alpine mountain ecosystems. While the 1983 survey documented medicinal uses centered around pastoralist practices, the 2024 data highlight a notable increase in the use of synanthropic plants, now utilized both medicinally and as food.

Physico-Chemical Properties of Granular Sorbents Based on Natural Bentonite Modified by Polyhydroxocations of Aluminum and Iron (III) by Co-Precipitation.

The physicochemical and adsorption properties of granular sorbents based on natural bentonite and modified sorbents based on it have been studied. It was found that modification of natural bentonite with iron (III) polyhydroxocations (mod. 1_Fe_5 GA) and aluminum (III) (mod.

FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells.

Farnesoid X receptor (FXR), a nuclear receptor, is expressed in calvaria and bone marrow stromal cells and plays a role in bone homeostasis. However, the mechanism of FXR-activated osteoblast differentiation remains unclear. In this study, we investigated the regulatory mechanism underlying FXR-activated osteoblast differentiation using bone morphogenetic protein-2 (BMP-2)-induced mouse ST-2 mesenchymal stem cells.

Tending to the Facial Surfaces of a Mathematical Biology Head-Scratcher: Why Does the Head of the Sea Turtle Resemble a Convex Zygomorphic Dodecahedron?

Two convex polyhedra that markedly resemble the head of the flatback sea turtle hatchling are identified. The first example is a zygomorphic tetragonal dodecahedron, while the other, an even better matching structure, is a related tetradecahedron, herein speculated to arise from this particular dodecahedron via known mechanisms gleaned from studies of the behavior of foams. A segmented, biomorphic, convex polyhedral model to address cephalic topology is thus presented stemming from solid geometry, anatomical observations, and a recently computed densest local packing arrangement of fifteen slightly oblate spheroids in which fourteen oblate spheroids surround a central such spheroid.

In vitro effect of hCG on cryptorchid patients' gubernacular cells: a predictive model for adjuvant personalized therapy.

Background: Cryptorchidism is the absence of one or both testicles in the scrotum at birth, being a risk factor for testis cancer and infertility. The most effective method to treat cryptorchidism is orchiopexy, followed by human chorionic gonadotropin (hCG) therapy; however, a portion of treated patients do not show a significant improvement in testis volume and vascularization after adjuvant therapy.

Methods: In this study, we generated an in vitro model to predict the patient response to hCG by cultivating and treating primary cells derived from five cryptorchid patients' biopsies of gubernaculum testis, the ligament that connects the testicle to the scrotum.

Food resilience and adaptation on the move: the importance of fostering studies on the Romani local knowledge systems.

This analysis explores the food local knowledge of the Romani people in Italy, one of the most significant and historically marginalised ethnic groups in Europe. Despite their centuries-long presence across European countries, the Romani community's culinary and herbal practices have often been overlooked. A preliminary study on Romani domestic food and home (plant) remedies was conducted via 106 interviews in Turin, Rome, and Naples during the past fifteen years among urban Romani community members (who migrated to Italy from Romania and Serbia approximately three decades ago).

The impact of leadership interventions on neonatal care: a systematic review of current literature.

Unlabelled: Effective leadership is essential in neonatal intensive care units (NICUs), where complex, high-stakes environments require coordinated multidisciplinary teamwork. Strong leadership improves clinical outcomes, team performance, and staff well-being. This systematic review assesses various leadership models and interventions in NICUs to identify best practices and areas for future research.

The opportunities in implementing assistive technology in oral health care for individuals with sensory impairments: a systematic review.

Purpose: People with sensory impairments (SI) face unique challenges in out-of-home care, especially in oral health (OH) care, compared to the general population. Various assistive technologies (ATs) and media are used to influence OH behaviors and outcomes for individuals with SI. This systematic review (SR) aimed to identify the types of ATs and assess their effectiveness for individuals with SI.

Clinimetric analysis of the numeric pain rating scale, patient-rated tennis elbow evaluation, and tennis elbow function scale in patients with lateral elbow tendinopathy.

Background: Currently, there is conflicting clinimetric data on the patient-rated tennis elbow evaluation (PRTEE) and a paucity of evidence regarding the reliability, validity, and responsiveness of the numeric pain rating scale (NPRS), and tennis elbow function scale (TEFS) in patients with lateral elbow tendinopathy.

Objective: Perform a comprehensive clinimetric analysis of the NPRS, PRTEE, and TEFS in a sample of patients ( = 143) with lateral elbow tendinopathy.

Methods: Establish the reliability, construct validity, responsiveness, meaningful clinically important difference (MCID), and minimal detectable change (MDC) values for the NPRS, PRTEE, and TEFS at the 3-month follow-up.

Efficacy and Safety of Polatuzumab-Vedotin plus Bendamustine and Rituximab in patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Systematic Review and Meta-Analysis.

Background: Diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin's lymphoma subtype, relapses or becomes refractory (R/R) in 40% of cases after initial treatment. Among the second-line treatments for these patients is CAR T-cell therapy, which is considered the gold standard and treatment better than SCT. For these patients, polatuzumab vedotin in combination with bendamustine and rituximab (Pola-BR) is a novel treatment.