8 results match your criteria: "International Medical Center Saitama Medical University[Affiliation]"
[Ⅳ. Predicting the Therapeutic Effect of Adjuvant Therapy with S-1 in Hormone Receptor-Positive, HER2-Negative Early Breast Cancer Based on Recurrence Risk-A Post-Hoc Exploratory Analysis of the POTENT Trial].
Gan To Kagaku Ryoho
December 2024
Dept. of Breast Oncology, International Medical Center Saitama Medical University.
Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism.
Endocr J
November 2024
Department of Health Promotion and Medicine of the Future, Kanazawa University Graduate School of Medicine, Ishikawa 920-8641, Japan.
Pheochromocytoma is a rare form of adrenal hypertension. This study aimed to investigate the clinical characteristics and associated genetic mutations in patients with pheochromocytoma and primary aldosteronism. We retrospectively analyzed data from 23 patients with pheochromocytoma diagnosed and treated between 2011 and 2022.
View Article and Find Full Text PDFClinicopathological prognostic characteristics and long‑term outcomes of patients with breast cancer and collagen disorder in comparison to those without collagen disorder.
Oncol Lett
November 2023
Department of Breast Oncology, International Medical Center Saitama Medical University, Hidaka, Saitama 350-1298, Japan.
Article Synopsis
- Collagen disorders are chronic autoimmune diseases, and their relationship with breast cancer risk is uncertain; this study focused on the outcomes of 25 women with both conditions.
- The study reviewed patient data, revealing that most had specific types of collagen disorders, and the majority received immunosuppressive treatments.
- Key findings showed that these patients had higher Ki-67 levels (indicating faster cancer cell growth) and lower rates of recurrence-free survival (RFS) and overall survival (OS) compared to a control group, suggesting the need for close follow-up for these patients.
Prorenin: What are its functions?
Hypertens Res
December 2022
Research Administration Center Saitama Medical University, Department of Cardiology International Medical Center Saitama Medical University, Saitama, Japan.
Origin of circulating 18-oxocortisol in the normal human adrenal.
Mol Cell Endocrinol
September 2022
Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.
18-Oxocortisol is the product of the metabolism of 11-deoxycortisol by the mitochondrial enzyme aldosterone synthase (CYP11B2). The traditional concept is that the CYP11B2 is exclusively expressed in zona glomerulosa cells and the 17α-hydroxylase (CYP17A1) enzyme, required to synthesize 11-deoxycortisol, is in the zona fasciculata of the human adrenal. It has been postulated that the substrate for 18-oxocortisol is either cortisol from the circulation or from zona fasciculata cells adjacent to the zona glomerulosa.
View Article and Find Full Text PDFUse of flexible endoscopic aspiration for an intraventricular small floating clot with hemorrhage: a technical note.
Neurosurg Rev
August 2021
Department of Neurosurgery, Saitama Cardiovascular and Respiratory Center, Kumagaya, Saitama, Japan.
Background: Although flexible endoscopy is effective for intraventricular lesions, it is less frequently used for hemorrhagic cases. In some hemorrhagic strokes, blood clots may plunge into the cerebral aqueduct and cause acute obstructive hydrocephalus. A flexible endoscope can aspirate clots and prevent acute hydrocephalus.
View Article and Find Full Text PDFDevelopment, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer.
Oncotarget
August 2014
Ovarian Cancer Research Center, University of Pennsylvania; Ludwig Cancer Research Center, University of Lausanne.
Tumor Endothelial Marker-1 (TEM1/CD248) is a tumor vascular marker with high therapeutic and diagnostic potentials. Immuno-imaging with TEM1-specific antibodies can help to detect cancerous lesions, monitor tumor responses, and select patients that are most likely to benefit from TEM1-targeted therapies. In particular, near infrared(NIR) optical imaging with biomarker-specific antibodies can provide real-time, tomographic information without exposing the subjects to radioactivity.
View Article and Find Full Text PDFDouble giant pseudoaneurysms of the aortic root and arch after ascending aorta replacement.
J Vasc Surg
April 2014
Department of Diagnostic Radiology, International Medical Center Saitama Medical University, Saitama, Japan.