MONARCH Inventory for Causal Attribution in Homeopathy Case Reports: Explanation and Elaboration.

Background:  The Modified Naranjo Criteria for Homeopathy (MONARCH) inventory is a novel and useful tool for assessing the likelihood of a causal relationship between the homeopathic intervention and the ultimate clinical outcome.

Objectives:  To explain and elaborate on the use of the MONARCH inventory to improve its consistency of use and thereby elevate the overall quality and evidentiary value of homeopathy case reports.

Explanation And Elaboration:  Each of the 10 MONARCH inventory domains is explained and elaborated with the aid of references from published literature and hypothetical clinical situations.

The safety and effectiveness of a novel annular keratopigmentation technique; a cross-sectional survey of patients.

Purpose: We investigated safety aspects and other patient experiences related to a novel Femtosecond Laser Assisted Annular Keratopigmentation technique (FLAAK).

Setting: Espace Nouvelle Vision Clinic in Paris.

Methods: Monocentric, post-operative, cross-sectional survey of patients who returned to the clinic for a color correction after the FLAAK procedure.

Searching for the Genus Epidemicus in Chinese Patients: Findings from the Clificol COVID-19 Clinical Case Registry.

Background:  The Clificol COVID-19 Support Project is an innovative international data collection project aimed at tackling some of the core questions in homeopathy. This paper reports on the further investigation of the genus epidemicus concept during the first wave of the pandemic in the Chinese population.

Methods:  The design is an observational clinical case registry study of Chinese patients with confirmed or suspected coronavirus disease 2019 (COVID-19).

The Clinical and Biological Effects of Homeopathically Prepared Signaling Molecules: A Scoping Review.

Background: Signaling molecules such as cytokines and interleukins are key mediators for the immune response in responding to internal or external stimuli. Homeopathically prepared signaling molecules have been used therapeutically for about five decades. However, these types of products are not available in many countries and their usage by homoeopaths is also infrequent.

Case Reporting in Homeopathy-An Overview of Guidelines and Scientific Tools.

Case reports have been of central importance to the development of homeopathy over the past 200 years. With a special focus on homeopathy, we give an overview on guidelines and tools that may help to improve the quality of case reports. Reporting guidelines such as CARE (se port), HOM-CASE (eopathic Clinical Reports), and the WissHom Documentation Standard help to improve the quality of reporting and strengthen the scientific value of a case report.

Data Collection during the COVID-19 Pandemic: Learning from Experience, Resulting in a Bayesian Repertory.

Background: A novel pandemic disease offered the opportunity to create new, disease-specific, symptom rubrics for the homeopathic repertory.

Objective: The aim of this study was to discover the relationship between specific symptoms and specific medicines, especially of symptoms occurring frequently in this disease.

Materials And Methods: Worldwide collection of data in all possible formats by various parties was coordinated by the Liga Medicorum Homeopathica Internationalis.

Treatment of Dyspepsia, Heartburn, and Related Symptoms with Gastricumeel Compared to Proton Pump Inhibitors: A Prospective Reference-Controlled Observational Study.

Background: Dyspepsia and heartburn are extremely common conditions, thus a search for safe and effective treatment alternatives is justified.

Objectives: To demonstrate the noninferiority of Gastricumeel (Ga6) in terms of effectiveness and safety to proton pump inhibitors (PPIs) in the treatment of patients with dyspepsia and/or heartburn.

Methods: Prospective, comparative, observational cohort study.

Development of a Prognostic Factor Prediction Model in Patients with Musculoskeletal Pain Treated with Homeopathy: An Individual Patient Data Meta-Analysis of Three Randomized Clinical Trials.

Background: Prognostic factor research methodology has not yet been applied to randomized clinical trial data of homeopathic medicines.

Objectives: To investigate the principle of individualization in homeopathy by developing a prognostic factor prediction model.

Method: A pooled, in-dividual patient data meta-analysis of 3 randomized trials -investigating the efficacy of a homeopathic gel (Spiroflor SRL®) containing Rhus toxicodendron as a key ingredient in osteoarthritis of the knee and acute low back pain.

Evaluation of the Modified Naranjo Criteria for Assessing Causal Attribution of Clinical Outcome to Homeopathic Intervention as Presented in Case Reports.

Objectives: The objective of this study was to establish the reliability and content validity of the "Modified Naranjo Criteria for Homeopathy-Causal Attribution Inventory" as a tool for attributing a causal relationship between the homeopathic intervention and outcome in clinical case reports.

Methods: Purposive sampling was adopted for the selection of information-rich case reports using pre-defined criteria. Eligible case reports had to fulfil a minimum of nine items of the CARE Clinical Case Reporting Guideline checklist and a minimum of three of the homeopathic HOM-CASE CARE extension items.

The Safety and Effectiveness of a Novel Annular Keratopigmentation Method: A Case Report.

Background: We investigated the safety and effectiveness of a novel aesthetic femtosecond-assisted annular keratopigmentation technique.

Case Report: A 21-year-old female patient in good general and ophthalmological health with the wish to change the colour of her eyes was treated with a femtosecond-assisted annular keratopigmentation technique. Pigment was inserted in a channel in the cornea (external diameter 9.

Model validity of randomised placebo-controlled trials of non-individualised homeopathic treatment.

Background: The comprehensive systematic review of randomised placebo-controlled trials (RCTs) in homeopathy requires examination of a study's model validity of homeopathic treatment (MVHT) as well as its risk of bias (extent of reliable evidence).

Objective: To appraise MVHT in those RCTs of non-individualised homeopathy that an associated investigation had judged as 'not at high risk of bias'.

Design: Systematic review.

The Effectiveness and Safety of a Homeopathic Medicinal Product in Pediatric Upper Respiratory Tract Infections With Fever: A Randomized Controlled Trial.

We investigated the clinical effectiveness of a homeopathic add-on therapy in a pediatric subpopulation with upper respiratory tract infections (URTI) in a randomized, controlled, multinational clinical trial. Patients received either on-demand symptomatic standard treatment (ST-group) or the same ST plus a homeopathic medication (Influcid; IFC-group) for 7 days. Outcome assessment was based on symptom and fever resolution and the Wisconsin Upper Respiratory Symptom Survey-21 (WURSS-21).

Homeopathic clinical case reports: Development of a supplement (HOM-CASE) to the CARE clinical case reporting guideline.

Objective: Develop a criteria catalog serving as a guideline for authors to improve the quality of reporting clinical case reports in homeopathy.

Method: An online Delphi process was initiated with a panel of 19 homeopathic experts from Europe, the USA and India. Homeopathy specific item selection took place in three rounds of adjusting.

Towards improving the reporting quality of clinical case reports in complementary medicine: assessing and illustrating the need for guideline development.

Background: Case reports have had a varying level of recognition as a source of evidence throughout the history of medicine. In recent years, there has been a revival of interest in clinical case reports in both conventional and complementary medicine. There is a need to further improve the reporting quality of clinical case reports of different Complementary and Alternative Medicine (CAM) therapies.

To which extent should potency choice in homeopathy be "regulated": has European legislation gone too far?

Despite ongoing controversy, homeopathy has become increasingly accepted as a "medical reality" by patients and doctors alike. This process has been accompanied by an increased quality of manufacturing, education, research, and regulation of homeopathy. This paper argues that European regulation may now have gone too far by indiscriminately prescribing that homeopathic medicines should be used in a potency of D4 and higher.