Predicting Mutations in Cutaneous Melanoma Patients Using Neural Network Analysis.

Point mutations at codon 600 of the BRAF oncogene are the most common alterations in cutaneous melanoma (CM). Assessment of BRAF status allows to personalize patient management, though the affordability of molecular testing is limited in some countries. This study aimed to develop a model for predicting alteration in BRAF based on routinely available clinical and histological data.

Modelling business processes in palliative care management: ways to optimise resource management.

Objective: Aim: To evaluate the impact of corrective coefficients on the income of multidisciplinary mobile palliative care teams (MMPCT) in Ukraine under different scenarios, such as new contracts, patient count, and service cost variability, to identify optimization pathways for resource management in palliative care.

Patients And Methods: Materials and Methods: A comprehensive literature review was conducted, including sources from JAMA Scholar and PubMed. The Monte Carlo method simulated 10 000 scenarios of uncertainty, such as patient count and diagnoses, to assess the effect of corrective coefficients.

Changes in somatic and mental health indicators of instructor-officers under stress.

Objective: Aim: To investigate changes in the indicators of somatic and mental health of instructor-officers in higher educational institutions with specific learning environment under stress.

Patients And Methods: Materials and Methods: The research involved instructor-officers of the National Academy of Internal Affairs (Ukraine, n = 86) with different teaching experiences: up to 10 years (group 1, n = 22), from 10 to 20 years (group 2, n = 31), over 20 years (group 3, n = 33). The study of somatic and mental health was carried out in September-October 2021 (Stage 1) and in September-October 2023 (Stage 2).

Biosafety of marine vessels: current trends and prospects.

Background: The global aggravation of the political situation in the world against the background of catastrophic changes in the Earth's ecology is inexorably growing. Despite the fact that most ships are equipped with Waste Water Treatment Plants (WWTP), pollution of the World Ocean remains a serious problem. One of the main reasons contributing to the pollution of the sea by ships is the lack of the ship's environmental protection equipment necessary for the work.

Evaluation of the efficacy of stomatitis prevention in prosthetics with complete dentures with additional fixation with the cream.

Background: The objective of the study is to evaluate a microbiological efficacy of prevention and development of prosthetic stomatitis in full removable prosthetics.

Material And Methods: All patients with complete absence of the teeth on the lower jaw were divided into four groups: individuals who used full removable dentures and did not use any fixation agents and adhered to conventional oral hygiene; patients with full removable dental prostheses who used the cream "Corega" to strengthen the fixation from the first day of prosthetics and adhered to conventional oral hygiene; patients with complete removable dentures who used Corega Comfort (GSK) to strengthen the fixation from the first day of prosthetics and adhered to conventional oral hygiene; patients with complete removable dentures who used Corega Comfort (GSK) to enhance the fixation and performed antibacterial cleaning of dentures using Biotablets "Corega" for cleaning dentures from the first day of prosthetics. Microbiological and mycological examination of the patients included microscopic examination of smears using conventional and luminescent methods of staining smears from the denture surface.

IMPACT OF TUMOR MOLECULAR PHENOTYPE ON SURVIVAL OF PATIENTS WITH GASTRIC CANCER AFTER RADICAL SURGERY.

The strategy for the treatment of gastric cancer (GC), in particular the use of the extended surgical interventions in different countries varies. The different proportion of specific molecular GC subtypes in various populations frequently is not taken into account for comparing treatment outcomes. This pilot study analyzes the association of survival of GC patients after the extended combined surgical interventions depending on the molecular subtype of the tumors.

THE MAIN ASPECTS OF COUNTERING PANDEMIC INFECTIOUS DISEASES THROUGH VACCINATION IN THE CONTEXT OF PROTECTING HEALTH AND OVERCOMING PSYCHOLOGICAL BARRIERS.

Objective: The aim: Study of opinions and attitudes of citizens towards vaccination, identification of the reasons for the refusal of vaccination, the main psychological barriers.

Patients And Methods: Materials and methods: As a result of the analysis the main reasons for the refusal of vaccination were systematized into 5 groups. For practical clarification of the main reasons for the refusal of vaccination, we conducted a survey of citizens of the family medicine outpatient clinic in one of the Ukrainian cities.

Multi-purpose transport monitoring of passenger-cargo traffic in Ukraine.

Background: The epidemiological and environmental security of states is the most important component for the functioning of the International Transport Corridors (ITC). The growing capacity of passenger and cargo flows increases the risk of the spread of dangerous infectious diseases in the territories of the countries on the route of the ITC. Preventing the introduction of dangerous infections by various vehicles and the activation of local natural foci are the priority in the anti-epidemic provision of the population of Ukraine.

Total Synthesis, Mechanism of Action, and Antitumor Efficacy of Camptothecin and Some of its Analogues.

Over the past 55 years of research, various experimental methods have been developed for the total synthesis of the anticancer camptothecin, a potent antitumor antibiotic, and its numerous active derivatives. The discoveries made in synthetic pathways of the camptothecin heterocyclic core have contributed significantly to the theory and strategy of directed organic synthesis aimed at finding effective anticancer drugs. The synthetic, medicinal chemistry of camptothecin, the development of structures of anticancer camptothecin analogues, and the mechanism of their activity in inhibiting the growth of different types of cancers, such as lung, ovarian, breast, pancreas, and stomach cancers are analyzed.

Influence of direct prostheses on the condition of the alveolar processes during dental implantation.

Objective: The purpose of this article is to study of the processes accompanying osseointegration of the dental implants using various plate prostheses as temporary constructions, as well as to compare the dynamics of changes in the state of the jaw alveolar processes.

Materials And Methods: The effect of dentures on the condition of the alveolar processes was studied in all patients according to the technique developed by L. Chulak on the 7th, 14th, 30th day and in 3, 6 months.

Restoring patient trust in healthcare: medical information impact case study in Poland.

Background: This study empirically evaluates the influence of medical information on patient trust at the physician level, the medical profession, hospitals, and with the payer. Restoring patient trust in a medical setting in Poland appears to be significantly affected due to the COVID-19 pandemic. Patient trust improves results from medical treatment, raises perception of healthcare performance, and smoothens the overall functionality of healthcare systems.

Motivators for medical staff with a high gap in healthcare efficiency: Comparative research from Poland and Ukraine.

Introduction: This article examines different motivators for medical staff in countries with a high gap in healthcare efficiency by comparing them in two healthcare systems-Polish (ie efficient) and Ukrainian (ie inefficient).

Method: This survey-based study applies a six-stage conceptual framework to two Polish and two Ukrainian hospitals as well as medical faculties of one university from each country. Following ethical approval, data were collected in the first quarter of 2019, using the 'Evaluation of motivators questionnaire for medical staff'.

Exploring a motivation of medical staff.

This paper aims to identify the true motivators (needs) of medical staff, compare them with the current labor incentives, and detect possible differences in motivators for main groups of medical staff. Observing personnel of 5 hospitals and students of the medical institute by special questionnaires, the author confirmed the hypothesis of different motivators for groups of medical staff with different ages, professions, and gender. The author used special questionnaires to collect the data.

Design, Synthesis, and Biological Evaluation of Peptidomimetic N-Substituted Cbz-4-Hyp-Hpa-Amides as Novel Inhibitors of Plasmodium falciparum.

A new series of peptidomimetic N-substituted Cbz-4-Hyp-Hpa-amides were designed, synthesized, and evaluated for inhibition of the Plasmodium falciparum. Substituents on the N-atom of the amide group were selected alkyl-, allyl-, aryl-, 2-hydroxyethyl-, 2-cyanoethyl-, cyanomethyl-, 2-hydroxyethyl-, 2,2-diethoxyethyl-, or 2-ethoxy-2-oxoethylamino groups, and about of 40 new compounds were synthesized and evaluated for antiplasmodial activity in vitro. Antimalarial activity has been investigated as for the final peptide mimetics, and their immediate predecessors, carrying TBDMS or TBDPS protecting groups on 4-hydroxyproline residue and 18 derivatives exhibited toxicity against P.