Interobserver Variability in the Histopathologic Assessment of Extrathyroidal Extension of Well Differentiated Thyroid Carcinoma Supports the New American Joint Committee on Cancer Eighth Edition Criteria for Tumor Staging.

Extrathyroidal extension (ETE) by papillary and follicular thyroid carcinoma can be associated with increased risk of tumor recurrence and mortality. In the seventh edition of its Cancer Staging Manual, the American Joint Committee on Cancer (AJCC) defined minimal ETE as the involvement of skeletal muscle (i.e.

Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity.

During the course of our consultation activity, we have recognized a peculiar form of thyroiditis in which multiple foci of fibrosis, most of which were associated with reactive atypia of the surrounding follicles, are present. We have referred to this condition, both in our consultation reports and in the third series of A.F.

The origin of neuroendocrine tumors and the neural crest saga.

In this essay, the role of the neural crest in the development of the vertebrate embryo is briefly described. The techniques used to document the neural crest origin of various cell types and the tumors arising from them are discussed, with emphasis on Le Douarin's quail-chick chimera model. The current dogma on the origin of the cells of the diffuse endocrine system is presented, and some personal conjectures based on the microscopic appearances of various types of normal, vestigial and neoplastic human tissues are offered to the reader as 'food for thought.

The encapsulated follicular variant of papillary thyroid carcinoma: back to the drawing board.

The encapsulated follicular variant of papillary carcinoma has become one of the most common diagnoses in thyroid tumor pathology. However, serious issues remain regarding the reproducibility of the diagnosis, its position in the scheme of thyroid neoplasms, and the clinical implications of the diagnosis. Strict morphologic criteria should be applied to its microscopic recognition, especially in regard to the nuclear features.