Dynamic changes in serum chloride concentrations during worsening of heart failure and its recovery following conventional diuretic therapy: A single-center study.

Background And Aims: Few data are available regarding the dynamic changes in the serum chloride concentrations in heart failure (HF) pathophysiology. The aim of the present study was to investigate changes in the serum chloride concentration under worsening HF and its recovery following conventional diuretic therapy.

Methods: Blood test data, including measurements of serum albumin/solutes and b-type natriuretic peptide, at both worsening and recovery of HF status, were obtained from 47 patients with definite HF.