1 results match your criteria: "Internal Medicine 1 - San Luigi Gonzaga Hospital - University of Turin[Affiliation]"
PREOPERATIVE TREATMENT WITH METYRAPONE IN PATIENTS WITH CUSHING'S SYNDROME DUE TO ADRENAL ADENOMA.
Endocr Connect
September 2018
M Terzolo, Department of Clinical and Biological Sciences, Internal Medicine 1 - San Luigi Gonzaga Hospital - University of Turin, Orbassano, Italy.
Objective: Metyrapone has been approved for the treatment of patients with Cushing's syndrome (CS), but only few retrospective clinical studies are available. The aim of our study was the prospective assessment of metyrapone as pre-operative treatment.
Design And Methods: Before adrenalectomy, 7 patients with ACTH-independent CS due to adrenal adenoma were prospectively treated with metyrapone for 3 months in 3 tertiary academic centers, with endocrine work-up and clinical evaluation at screening and at predefined evaluation time points (Day 14, 31, 48, 65, 82).