A double-blind randomized trial of hyperbaric oxygen for persistent symptoms after brain injury.

In this double-blind randomized trial, adults with persistent symptoms following non-stroke brain injury received 40 hyperbaric oxygen (HBO) sessions or 40 sham sessions over 12 weeks. Three months later, all were offered 40 unblinded HBO sessions. Participants completed the Neurobehavioral Symptom Inventory (NSI) at baseline, 13 weeks (after 40 chamber sessions), 6 months, 9 months (after the second chamber series), and 12 months, with prime outcome at 13 weeks, and additional questionnaires, neuropsychological tests, and functional measures.