From Waste to Power: Developing Structural Supercapacitors with Red Mud and Jute Stick.

Developing effective, cost-efficient, and eco-friendly energy storage solutions is crucial for sustainable building structures. Red mud, a waste material, was used as the electrolyte and separator in supercapacitors, alongside activated carbon derived from jute sticks coated on steel mesh electrodes. Tests on RM-enhanced supercapacitors showed that 20 % by weight of RM was the best amount.

Chemical properties of peat micro particles modified asphalt.

This study investigated the chemical properties of peat microparticles modified asphalt (Pt.M.A.

Three-dimensional covalent organic framework-based artificial interphase layer endows lithium metal anodes with high stability.

To gain a deeper understanding and address the scientific challenges of lithium dendrite growth, a robust solid-state electrolyte interface (SEI) with good mechanical properties and rapid ion conduction is crucial for the advancement of lithium metal batteries. Artificial SEI layers based on organic polymers, such as covalent organic frameworks (COF), have garnered widespread attention due to their flexible structural design and tunable functionality. In this work, a COF with 3D spatial geometric symmetry and a fully covalent topology was synthesized and used as artificial SEI layers.

Al-N Bridge Site Enabling Interlayer Charge Transfer Boosts the Direct Photosynthesis of Hydrogen Peroxide from Water and Air.

Manipulating the electronic environment of the reactive center to lower the energy barrier of the rate-determining water oxidation step for boosting the direct generation of HO from water, air, and sunlight is fascinating yet remains a grand challenge. Driven by a first-principles screening across a series of metal single atoms in carbon nitride, we report a class of an Al-N bridge site enabling interlayer charge transfer in carbon nitride nanotubes (CNNT-Al) for the highly efficient photosynthesis of HO directly from water, oxygen, and sunlight. We demonstrate that the interlayered Al-N bridge site in CNNT-Al is able to activate the neighboring surface N atom for promoting the rate-determining step of the two-electron water oxidation to HO.

A Multipole-Based Reactive Force Field for Hydrocarbons.

The computational complexity of quantum chemistry methods has prompted the development of reactive force fields, facilitating practical applications of molecular dynamics simulations for large-scale reactive systems. Current reactive force fields typically employ intricate corrections based on prior chemical knowledge, which severely impedes their further advancement. This study presents a new atomic multipole-based reactive model with bond free (OPERATOR).

Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability.

Background: Atheroprotective shear stress preserves endothelial barrier function, while atheroprone shear stress enhances endothelial permeability. Yet, the underlying mechanisms through which distinct flow patterns regulate EC integrity remain to be clarified. This study aimed to investigate the involvement of Kindlin-2, a key component of focal adhesion and endothelial adherens junctions crucial for regulating endothelial cell (EC) integrity and vascular stability.

Regulation of leukemogenesis via redox metabolism.

Redox metabolism plays a central role in the cellular metabolism network, involves catabolic and anabolic reactions of diverse biomass, and determines the redox state of cells. It can be quantitatively and conveniently measured in living cells and organisms with genetically encoded fluorescent sensors, providing novel insights that cannot be readily acquired via conventional metabolic assays. Here, we review the recent progress on the regulation of leukemogenesis via redox metabolism, especially redox biosensor-based findings.

Patterns and drivers of carbon stock change in ecological restoration regions: A case study of upper Yangtze River Basin, China.

Balancing ecology and human development has been a long and wide concern. The upper Yangtze River Basin (UYRB) of China has implemented large important ecological restoration projects since the last century. These restoration practices have changed land use patterns within the UYRB, consequently impacting the local carbon cycle.

Triple-Layered Noncombustible PEO-Based Solid Electrolyte for Highly Safe Lithium-Metal Batteries.

Lithium-metal batteries are currently recognized as promising next-generation technologies owing to their high energy density. Solid polymer electrolytes, particularly those based on polyethylene oxide (PEO), are lauded for their leakage resistance, safety, and flexible design. Despite the ongoing fire safety- and ionic conductivity-related concerns, a novel noncombustible solid polymer electrolytes with superior ionic conductivities are introduced here with additive decabromodiphenyl ethane and zeolite.

A comprehensive investigation of associations between cell death pathways and molecular and clinical features in pan-cancer.

Background: Regulated cell death (RCD) pathways play significant roles in tumorigenesis. However, systematic investigation into correlations between RCD and various molecular and clinical features, particularly anti-tumor immunity and immunotherapy response in pan-cancer remains lacking.

Methods: Using the single-sample gene set enrichment analysis, we quantified the activities of six RCD pathways (apoptosis, autophagy, ferroptosis, cuproptosis, necroptosis, and pyroptosis) in each cancer specimen.

Mechanisms of Bioactive Lipids to Modulate Master Regulators of Lipid Homeostasis and Inflammation in Metabolic Syndrome.

Metabolic Syndrome (MetS) refers to the co-occurrence of a constellation of metabolic diseases in the same individual, such as abdominal/visceral obesity, insulin resistance or diabetes, alterations in the lipid profile (dyslipidemias), and/or hypertension, which promotes the development of other cardiometabolic and hepatic diseases. Dyslipidemia and metabolic dysfunction- associated steatotic liver disease (MASLD), previously termed nonalcoholic fatty liver disease (NAFLD), are common MetS pathologies closely related to lipid metabolism. Alterations in the metabolism of proteins, carbohydrates, and lipids, caused by an excessive intake of nutrients and abnormal accumulation of body fat, which promotes chronic low-grade inflammation, are pivotal aspects of MetS development.

Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in the TNF pathway.

Tumor necrosis factor (TNF)-induced receptor-interacting serine/threonine protein kinase 1 (RIPK1)-mediated cell death, including apoptosis and necroptosis, is increasingly recognized as a major driver of inflammatory diseases. Cell death checkpoints normally suppress RIPK1 kinase to safeguard the organism from its detrimental consequences. However, the mechanisms licensing RIPK1 kinase activity when a protective checkpoint is disabled remain unclear.

Stereological study of organelle distribution in human mature oocytes.

The ultrastructure of human oocytes has been described only qualitatively. To offer a precise organelle spatial distribution and organelle volume during the main maturation stages, we previously conducted stereological studies on prophase-I (GV) and metaphase-I (MI) oocytes, and here we present results on metaphase-II (MII) oocytes. Five donor oocytes from different donors were processed for transmission electron microscopy, and quantification of organelle distribution was performed using point-counting stereology.

Ultralow-pressure-driven polarization switching in ferroelectric membranes.

Van der Waals integration of freestanding perovskite-oxide membranes with two-dimensional semiconductors has emerged as a promising strategy for developing high-performance electronics, such as field-effect transistors. In these innovative field-effect transistors, the oxide membranes have primarily functioned as dielectric layers, yet their great potential for structural tunability remains largely untapped. Free of epitaxial constraints by the substrate, these freestanding membranes exhibit remarkable structural tunability, providing a unique material system to achieve huge strain gradients and pronounced flexoelectric effects.

Bright and Stable Cyan Fluorescent RNA Enables Multicolor RNA Imaging in Live Escherichia coli.

Fluorescent RNAs (FRs), which are RNA aptamers that bind and activate their cognate small fluorogenic dyes, have provided a particularly useful approach for imaging RNAs in live cells. Although the color palette of FRs is greatly expanded, a bright and stable cyan FR with good biocompatibility and biorthogonality with currently available FRs remains desirable but is not yet developed. Herein, the development of Myosotis is described, an RNA aptamer that emits bright cyan fluorescence upon binding a novel GFP chromophore-like fluorophore called DBT.

Streamlined Synthesis of Ellagitannins: Site-Selective Functionalization of the Glucose Core and Stereodivergent Construction of the Hexahydroxydiphenoic Groups.

Ellagitannins are a class of plant polyphenols with a structural diversity of around 1000. Because those with attractive biological activities have been reported, synthetic studies have been performed. The purpose of this perspective is to provide an outlook toward future developments on ellagitannin chemistry and medicinal applications by overviewing synthetic studies.

Electrochemical Conversion of Biomass-Derived 5-Hydroxymethylfurfural into 2,5-Furandicarboxylic Acid by Time-Controlled Aerosol-Assisted Chemical Vapor Deposited FeNi Catalyst.

The conversion of 5-hydroxymethylfurfural (HMF) into valuable chemicals, such as 2,5-furandicarboxylic acid (FDCA), is pivotal for sustainable chemical production, offering a renewable pathway to biodegradable plastics and high-value organic compounds. This pioneering study explores the synthesis of FeNi nanostructures via aerosol-assisted chemical vapor deposition (AACVD) for the electrochemical oxidation of HMF to FDCA. By adjusting the deposition time, we developed two distinct nanostructures: FeNi-40, which features nanowires with spherical terminations, and FeNi-80, which features aggregated spherical structures.

An Extensive Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions.

Understanding how proteins in different mammalian tissues are regulated is central to biology. Protein abundance, turnover, and post-translational modifications like phosphorylation, are key factors that determine tissue-specific proteome properties. However, these properties are challenging to study across tissues and remain poorly understood.