Exploring coach and parent transformational leadership and their associations with social identity in adolescents.

The main objective of this study was to explore the associations between the transformational leadership of coaches and parents and adolescent athletes' social identity and examine the roles of gender and the stage of adolescence in these relationships. Furthermore, this study aimed to provide empirical evidence on measurement invariance across gender and the adolescent stage in the adapted Spanish version of the Social Identity Questionnaire for Sport (SIQS). The sample consisted of 656 athletes (299 males and 357 females) from 12 to 18 years old (M = 15.

Enjoyment in Sport and Alcohol Use among Adolescents: Examining the Mediating Role of Engagement.

Background: Alcohol consumption among young people is a significant public health concern. Previous studies have indicated that participation in sports, through the positive experiences it offers, may function as a protective factor against alcohol intake. This study aimed to examine the influence of enjoyment and personal fulfillment on adolescent alcohol use, exploring the role of engagement with sports as a mediating variable.

Chronic NOD2 stimulation by MDP confers protection against parthanatos through M2b macrophage polarization in RAW264.7 cells.

Innate immune cells show enhanced responsiveness to secondary challenges after an initial non-related stimulation (Trained Innate Immunity, TII). Acute NOD2 activation by Muramyl-Dipeptide (MDP) promotes TII inducing the secretion of pro-inflammatory mediators, while a sustained MDP-stimulation down-regulates the inflammatory response, restoring tolerance. Here we characterized in-vitro the response of murine macrophages to lipopolysaccharide (LPS) challenge under NOD2-chronic stimulation.

Engagement in Youth Athletes as a Positive Experience in Sport: Implications of Gender, Age, and Competitive Level.

The aim of this study was to examine athlete engagement and its relationships with indicators of the quality of the athlete's sport experience, exploring potential differences according to gender, age, and competitive level. Furthermore, this study validated the Athlete Engagement Questionnaire (AEQ) in young athletes and confirmed its factor structure. A total of 1188 athletes (43.

Athlete's Personal Values and the Likelihood of Alcohol Use and Heavy Drinking during Adolescence.

Sport is considered an exceptional activity for promoting healthy lifestyles, but the relationship between sport and alcohol consumption is inconclusive. Research on personal values may shed light on this issue and thus make it possible to find effective ways to prevent alcohol misuse in adolescents. The main objectives of this study were to explore the relationships between personal values and alcohol consumption amongst adolescent athletes and to validate the Portrait Values Questionnaire-21 (PVQ-21) in this population.

Is emotional support the key to improving emotion regulation? A machine learning approach.

Background: According to the emotion regulation process, situation selection comprises actions that increase or decrease the likelihood of being in contexts that foster a certain type of emotion, positive or negative. This concept is complemented by the social basis theory, which starts with the assumption that the primary ecology of humans is characterized by its social components. Thus, reduced access to social relationships increases cognitive and physiological effort, which leads to a decrease in well-being.

Optimization and comparative analysis of LAMP and PCR techniques for the detection of leptospiral DNA in Golden Syrian hamsters.

Leptospirosis is a zoonotic disease with significant public health and economic impact worldwide. Rapid and accurate diagnosis is essential for effective prevention and treatment. This study optimized a loop-mediated isothermal amplification (LAMP) assay using BFo isothermal DNA polymerase with different colorimetric indicators.

Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis.

Purpose: To describe data on epidemiology, microbiology, clinical characteristics and outcome of adult patients admitted in the intensive care unit (ICU) with secondary peritonitis, with special emphasis on antimicrobial therapy and source control.

Methods: Post hoc analysis of a multicenter observational study (Abdominal Sepsis Study, AbSeS) including 2621 adult ICU patients with intra-abdominal infection in 306 ICUs from 42 countries. Time-till-source control intervention was calculated as from time of diagnosis and classified into 'emergency' (< 2 h), 'urgent' (2-6 h), and 'delayed' (> 6 h).

Epidemiology and age-related mortality in critically ill patients with intra-abdominal infection or sepsis: an international cohort study.

Objective: To describe epidemiology and age-related mortality in critically ill older adults with intra-abdominal infection.

Methods: A secondary analysis was undertaken of a prospective, multi-national, observational study (Abdominal Sepsis Study, ClinicalTrials.gov #NCT03270345) including patients with intra-abdominal infection from 309 intensive care units (ICUs) in 42 countries between January and December 2016.

Cross-sectional analysis of the Parkinson's disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life.

Growing evidence suggests that non-motor symptoms (NMS) in Parkinson's disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores.

Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis.

Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity.

Excessive buccal saliva in patients with Parkinson's disease of the French COPARK cohort.

We describe excessive buccal saliva (EBS) prevalence in patients with Parkinson's Disease (PD) and controls of the COPARK study, its changes between "ON" and OFF" conditions and over time, its impact on Health-related Quality of life (HRQoL), and factors associated with this condition. We studied 671 ambulatory PD patients and 177 age/sex-matched controls. We defined "sialorrhea" as UPDRS item #6 (salivation) = 1 or 2; and "drooling" as item #6 = 3 or 4.

Psychotherapists' emotional and physiological reactions toward patients with either borderline personality disorder or depression.

There is a marked difference between the effects of psychotherapy for major depressive disorder (MDD) and borderline personality disorder (BPD), with treatment being less effective for the latter. Considering the importance of the therapeutic relationship in the prognosis of therapeutic results, some of these differential effects might be explained by the distinctive reactions that patients elicit in their therapists. The aim of the present research was to characterize therapists' perceptions of their emotional and physiological reactions to patients diagnosed with MDD or BPD.

Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project.

Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).

Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.

Heterogeneity in Adipose Stem Cells.

Adipose stem cells (ASCs) are the basis of procedures intended for tissue regeneration. These cells are heterogeneous, owing to various factors, including the donor age, sex, body mass index, and clinical condition; the isolation procedure (liposuction or fat excision); the place from where the cells were sampled (body site and depth of each adipose depot); culture surface; type of medium (whether supplemented with fetal bovine serum or xeno-free), that affect the principal phenotypic features of ASCs. The features related to ASCs heterogeneity are relevant for the success of therapeutic procedures; these features include proliferation capacity, differentiation potential, immunophenotype, and the secretome.

Adipose tissue stem cells in regenerative medicine.

Adipose tissue-derived stem cells (ADSCs) are mesenchymal cells with the capacity for self-renewal and multipotential differentiation. This multipotentiality allows them to become adipocytes, chondrocytes, myocytes, osteoblasts and neurocytes among other cell lineages. Stem cells and, in particular, adipose tissue-derived cells, play a key role in reconstructive or tissue engineering medicine as they have already proven effective in developing new treatments.

B cells inhibit the antitumor immunity against an established murine fibrosarcoma.

Despite the classic role of B cells in favoring the immune response, an inhibitory action of B lymphocytes in tumor immunity has emerged in certain studies. In methylcolanthrene-induced murine fibrosarcoma (MCC), the loss of immunogenicity and the establishment of tolerance are paralleled by systemic immune suppression and the appearance of BIL-10 cells in tumor-draining lymph nodes. The present study aimed to assess the role of the BIL-10 cell population in the immune evasion and tolerance induced by MCC through the depletion of B cells in mice at various times of tumor progression: Prior to or subsequent to tumor implantation.

Urban Chagas disease in children and women in primary care centres in Buenos Aires, Argentina.

The primary objective of this study was to estimate the prevalence of this disease in women of childbearing age and children treated at health centres in underserviced areas of the city of Buenos Aires. Demographic and Chagas disease status data were collected. Samples for Chagas disease serology were obtained on filter paper and the reactive results were confirmed with conventional samples.