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Background: "The study of the occurrence of disease" is a short but quite precise definition of epidemiology, as it includes both descriptive and analytic approaches. Whereas descriptive studies of the distribution of diseases and their potential causal factors may generate hypotheses about disease aetiology, causal inferences may most safely be drawn from analytical testing through properly designed observational studies.

Methods: The most commonly used observational designs are the retrospective case-control and the prospective cohort studies.

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