17 results match your criteria: "Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa)[Affiliation]"
Anaphylaxis: Spotlight on Inflammation.
Clin Exp Allergy
January 2025
Department of Health Sciences, University of Florence, Florence, Italy.
Relevance of gut microbiome research in food safety assessment.
Gut Microbes
October 2024
Department of Bioactivity and Food Analysis, Instituto de Investigación en Ciencias de la Alimentación (CIAL), CSIC-UAM, CEI (UAM+CSIC), Madrid, Spain.
Article Synopsis
- The gut microbiome is crucial for our body's functioning, but the effects of non-nutritious food components on it are often ignored.
- Certain food additives and microplastics may negatively impact the gut microbiome and human health, and understanding the mechanisms behind this is essential.
- Recommendations include integrating gut microbiome research into food safety assessments to better evaluate the risks of food additives and contaminants.
Increased miR-21-3p levels in extracellular vesicles of children with food anaphylaxis.
Pediatr Allergy Immunol
September 2024
Department of Allergy and Immunology, IIS-Fundación Jiménez Díaz, Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain.
Elife
September 2024
Chemokine Signaling group, Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, Campus de Cantoblanco, Madrid, Spain.
Article Synopsis
- - CXCR4 is a chemokine receptor that plays key roles in immune cell movement, organ development, and various diseases, including cancer and HIV-1 infection, with only one blocker, plerixafor, currently used clinically.
- - Recent research shows that when activated by CXCL12, CXCR4 changes its structure, reducing membrane-bound units and forming larger immobile clusters necessary for cells to respond to chemical signals.
- - Using molecular modeling, scientists discovered a compound, AGR1.137, that disrupts these CXCR4 clusters without interfering with CXCL12 binding, effectively blocking cellular response to chemical gradients in laboratory settings.
Role of the mesenchymal stromal cells in bone marrow failure of Fanconi Anemia patients.
Front Cell Dev Biol
July 2024
Hematology and Hemotherapy Unit, Pediatric Onco-hematology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
Introduction: Fanconi anemia (FA) is an inherited disorder characterized by bone marrow failure, congenital malformations, and predisposition to malignancies. Alterations in hematopoietic stem cells (HSC) have been reported, but little is known regarding the bone marrow (BM) stroma. Thus, the characterization of Mesenchymal Stromal Cells (MSC) would help to elucidate their involvement in the BM failure.
View Article and Find Full Text PDFAllergic inflammation triggers dyslipidemia via IgG signalling.
Allergy
October 2024
Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Article Synopsis
- Allergic diseases, starting early in life, create a chronic inflammatory environment that is linked to metabolic disorders and cardiovascular risks, but the exact mechanisms are still unclear.
- Researchers conducted experiments using a mouse model and various methods to study how allergic inflammation impacts lipid metabolism, specifically focusing on triglyceride levels and gene expression related to fat metabolism.
- The findings indicate that allergic inflammation leads to a specific lipid profile and increased triglycerides in the blood, primarily driven by IgG-mediated responses rather than traditional T-cell reactions.
Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment.
Front Immunol
April 2024
Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain.
Objectives: The aim of the study was to characterize the circulating immunome of patients with EoE before and after proton pump inhibitor (PPI) treatment in order to identify potential non-invasive biomarkers of treatment response.
Methods: PBMCs from 19 healthy controls and 24 EoE patients were studied using a 39-plex spectral cytometry panel. The plasmacytoid dendritic cell (pDC) population was differentially characterized by spectral cytometry analysis and immunofluorescence assays in esophageal biopsies from 7 healthy controls and 13 EoE patients.
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin.
Elife
April 2024
Centro de Biologia Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Article Synopsis
- * Research involving ICAM-1 knockout cells reveals that it regulates the polarity of epithelial cells independently of leukocyte adhesion by interacting with an actomyosin network.
- * The study highlights the importance of the protein EBP50, which works alongside ICAM-1 to influence the organization of bile canalicular structures, suggesting new therapeutic approaches for maintaining epithelial function under inflammation.
Editorial comment on "The alternative bile acid pathway can predict food allergy persistence in early childhood".
Pediatr Allergy Immunol
October 2023
Pediatric Allergy Unit, Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland.
Meglumine gadoterate induces immunoglobulin-independent human mast cell activation via MRGPRX2.
Allergy
December 2023
Department of Allergy, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology.
Allergy
October 2023
Molecular Biology Unit, Hospital Universitario de la Princesa, Madrid, Spain.
Article Synopsis
- Eosinophilic esophagitis (EoE) is a chronic allergic disease affecting the esophagus, and researchers used proteomics and RNA sequencing to study changes in the esophageal tissue of EoE patients compared to healthy controls.
- Out of 1667 identified proteins, 363 were differentially accumulated in EoE, while RNA sequencing revealed 1993 differentially expressed genes, highlighting a significant correlation between RNA and protein levels, especially for certain mRNA-protein pairs.
- The study provided new insights into the pathogenesis of EoE, revealing alterations in immune responses and epithelial processes, and emphasized the importance of combining proteomic and transcriptomic data for a better
Mapping the way to strengthening epithelial barriers: Neuronal circuits in mucus regulation.
Allergy
October 2023
Department of Allergy and Immunology, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Pathogenesis, immunology, and immune-targeted management of the multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS): EAACI Position Paper.
Pediatr Allergy Immunol
January 2023
Department of Paediatric Medicine, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands.
Article Synopsis
- Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19, developing around 4 weeks after infection, characterized by hyperinflammation and potential shock.* -
- The European Academy of Allergy and Clinical Immunology formed a task force to create guidelines for diagnosing, treating, and monitoring MIS-C, focusing on its unclear immunological mechanisms.* -
- Current treatment involves supportive care and immunosuppressive agents like steroids, and regular follow-ups are essential to monitor for complications, with vaccination against COVID-19 shown to help prevent MIS-C.*
Protocol to desensitize human and murine mast cells after polyclonal IgE sensitization.
STAR Protoc
December 2022
Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Madrid, Spain; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CNB)-CSIC, Madrid, Spain; Faculty of Experimental Sciences, Universidad Francisco de Vitoria (UFV), Madrid, Spain; Department of Medicine, McMaster Immunology Research Centre (MIRC), McMaster University, Hamilton, ON, Canada. Electronic address:
Article Synopsis
- - This protocol offers clear steps to desensitize mast cells (MCs) from humans and mice after they have been sensitized with polyclonal IgE.
- - It includes methods for assessing MC degranulation by measuring specific markers (CD63 and CD107a) using flow cytometry and evaluating β-hexosaminidase activity.
- - The desensitized MCs can be used for various applications like co-culture with other cells, immunofluorescence, live imaging, and omics studies, with full details available in López-Sanz et al. (2022).
Mast Cell Desensitization in Allergen Immunotherapy.
Front Allergy
June 2022
Department of Basic Medical Sciences, Facultad de Medicina, Institute of Applied Molecular Medicine Nemesio Díez, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Madrid, Spain.
Article Synopsis
- * AIT involves a short-term desensitization of mast cells and a long-term regulatory T cell response, benefiting around 70% of patients for up to 3 years after stopping treatment.
- * Challenges of AIT include its lengthy duration, possible allergic reactions during treatment, and variable effectiveness; understanding its immunology better, along with using omics strategies, may help identify patient-specific responses and predict who will benefit from AIT.
The impact of type 2 immunity and allergic diseases in atherosclerosis.
Allergy
November 2022
Department of Immunology, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM), Madrid, Spain.
Article Synopsis
- Allergic diseases are immunological disorders triggered by allergens, leading to type 2 immunity and IgE responses, with a rising prevalence similar to cardiovascular diseases (CVD).
- CVD often stems from atherosclerosis, characterized by endothelial dysfunction and Th1 inflammation, raising questions about the relationship between allergic conditions and heart health.
- The review explores the phases of allergic pathology, immunological mechanisms of atherosclerosis, and the complex clinical connections between allergic diseases (like asthma and food allergies) and CVD, including the role of various immune cells and mediators in these conditions.
Liaison psychiatry before and after the COVID-19 pandemic.
Psychiatry Res
August 2022
Department of Psychiatry, Hospital Universitario de La Princesa, c/ Diego de León, 62, (28006) Madrid, Spain; Instituto de Investigación Sanitaria Hospital Universitario de la Princesa (IIS-Princesa), c/ Diego de León, 62, (28006) Madrid, Spain; Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Av/ Monforte de Lemos, 3-5. Pabellón 11. Planta 0 (28029) Madrid, Spain; Departament of Psychiatry, Universidad Autónoma de Madrid, c/ Arzobispo Morcillo, 4, (28029) Madrid, Spain.
Introduction: the COVID-19 pandemic had an impact on hospital admissions. The clinical profiles of patients referred to liaison psychiatry teams (LPT) remained stable over the last few decades. We postulate changes in patient profiles due to the COVID-19 pandemic.
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