65 results match your criteria: "Institute of Translational Medicine (IMT)[Affiliation]"

Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review.

J Diabetes Res

December 2024

Neuroscience Research Group (NeURos), Neurovitae-UR Neuroscience Center, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia.

Peripheral neuropathy is a common cause of morbidity in diabetes. Despite recent advancements in early diagnosis methods, there is a need for practical, highly sensitive, and cost-effective screening methods in clinical practice. This study summarizes evidence from systematic reviews and meta-analyses on the diagnostic accuracy of validated screening methods for diabetic peripheral neuropathy.

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Association between retinal vessels caliber and systemic health: A comprehensive review.

Surv Ophthalmol

November 2024

Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Programme for Ocular Inflammation and Infection Translational Research (PROTON), Singapore; Singapore Eye Research Institute, Singapore; Duke NUS Medical School, Singapore. Electronic address:

Article Synopsis
  • The retinal microvasculature can be visualized non-invasively, making it a promising method for detecting microvascular changes linked to systemic diseases like diabetes, hypertension, and cerebrovascular issues.
  • Research shows that structural changes in the retinal blood vessels correlate with cardiovascular risks and can predict complications and mortality from systemic hypertension.
  • There is a push for better diagnostic tools using retinal imaging, emphasizing the importance of understanding 3D vascular structures and advocating for larger, long-term studies to clarify how these retinal changes relate to various systemic health conditions.
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Influence of gender on Behçet's disease phenotype and irreversible organ damage: Data from the International AIDA Network Behçet's Disease Registry.

Joint Bone Spine

November 2024

Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy. Electronic address:

Article Synopsis
  • The study aimed to explore gender differences in the phenotypical expression of Behçet's disease (BD) using data from the International AIDA Network Registry, focusing on damage index, disease manifestations, and cardiovascular risk.
  • A total of 1024 patients (567 males and 457 females) were examined, revealing that males had a significantly higher overall damage index and more frequent occurrences of uveitis and vascular involvement, while females showed higher instances of arthralgia, arthritis, and CNS involvement.
  • Key factors associated with major organ involvement included male gender, treatment with biologic agents, origin from endemic regions, and longer disease duration, indicating a more severe course of BD in males compared to females.
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Antiviral therapy for cytomegalovirus retinitis: A systematic review and meta-analysis.

Surv Ophthalmol

November 2024

Programme for Ocular Inflammation & Infection Translational Research, National Healthcare Group, Singapore, Singapore; Department of Bioinformatics, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, UK; UCL-Institute of Ophthalmology, UK; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Duke NUS Medical School, Singapore; Singapore Eye Research Institute, Singapore.

Article Synopsis
  • Cytomegalovirus retinitis (CMVR) is a major cause of blindness in advanced AIDS patients, with varied treatment approaches due to the lack of established guidelines.
  • A review of 59 studies revealed an 18% improvement in visual acuity and a 90% rate of inflammation resolution, with ganciclovir being the most commonly used antiviral treatment.
  • Notably, patients on antiretroviral therapy (ART) had a significantly lower recurrence rate of inflammation compared to those not on ART, and the most common side effect reported was neutropenia related to ganciclovir.
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Uveitis characteristics and multiple sclerosis phenotype of patients with multiple sclerosis-associated uveitis: A systematic review and meta-analysis.

PLoS One

October 2024

Ophthalmology Interest Group-Universidad del Rosario (OIG UR), Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Article Synopsis
  • - Purpose: The study aimed to summarize and analyze the characteristics of uveitis and the phenotype of multiple sclerosis (MS) in patients with multiple sclerosis-associated uveitis (MSAU) through a systematic review and meta-analysis conducted on data up to January 2023.
  • - Methods: A thorough literature search was conducted across multiple databases, focusing on relevant studies involving patients with MSAU. The analysis included various study designs, assessing quality and risk of bias, and examining uveitis characteristics and MS phenotype using statistical software.
  • - Results: The meta-analysis covered 36 studies with 1,257 patients revealing a mean patient age of 38.2 years, with most cases being female (67%). Notably
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Article Synopsis
  • - IL-6 inhibitors are emerging as effective treatments for non-infectious uveitis (NIU) that doesn't respond well to standard therapies, addressing key issues like inflammation and vision loss.
  • - Review studies highlight that these biologic agents have succeeded in reducing inflammation in 34% to 88% of patients and decreasing dependency on corticosteroids by about 55%.
  • - Although results are promising, showing improvements in visual acuity and macular edema, more research is necessary to confirm the long-term safety and effectiveness of IL-6 inhibitors in uveitis management.
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Article Synopsis
  • Intermediate uveitis involves inflammation of the vitreous and pars planitis, which can stem from various causes including infections, systemic diseases, or may be idiopathic (unknown origin).
  • The specific term "pars planitis" refers to the idiopathic form characterized by distinctive findings like snowballs and snowbanks in the eye.
  • Diagnosis relies on recognizing symptoms (like floaters) and conducting a thorough eye examination, while advanced techniques like PCR testing help identify underlying infectious or neoplastic causes.
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Article Synopsis
  • - We agree with Dr. Kasperkiewicz's points about improving the diagnosis of ocular pemphigoid and distinguishing it from pseudopemphigoid.
  • - Relying only on clinical signs can lead to incorrect diagnoses, highlighting the need for more accurate methods.
  • - A biopsy can be complicated and sometimes requires multiple attempts, so it's essential to have a team approach with both ophthalmologists and dermatologists involved in the assessment.
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Article Synopsis
  • Dry eye disease (DED) may be associated with axial spondylarthritis (axial-SpA), as this study aims to investigate the correlation between the two conditions and identify related variables.
  • Out of 71 axial-SpA patients, 64.8% reported DED symptoms compared to only 15.8% of 19 healthy controls, suggesting a significantly higher prevalence of DED in axial-SpA patients.
  • Various ocular tests revealed that axial-SpA patients exhibited poorer tear production and ocular surface health, indicated by lower Schirmer test scores, shorter tear break-up times, and higher staining levels, reinforcing the link between axial-SpA and DED.
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Corticosteroids are frequently prescribed across medical disciplines, yet they are associated with various adverse effects, including neuropsychiatric symptoms, documented since their introduction over 60 years ago. The cellular mechanisms underlying neuropsychiatric symptoms are complex and somewhat obscure, involving multiple pathways. Notably, they include changes in excitability, cellular death of hippocampal and striatal neurons, and increased inflammation and oxidative stress.

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Ibrutinib-Related Uveitis in Non-Hodgkin Lymphoma Patients: A Case Report and Literature Review.

Ocul Immunol Inflamm

October 2024

Ophthalmology Interest Group, Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To report two cases of ibrutinib-related uveitis and review the literature to date.

Methods: We report two cases of ibrutinib-related uveitis using CARE guidelines and review the cases reported in the literature.

Results: Case 1) A 55-year-old female with recurrent primary central nervous system lymphoma presented with bilateral decreased visual acuity, photophobia, and floaters that started one month after initiating oral treatment with ibrutinib.

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Clinical Characteristics of Ocular Mucous Membrane Pemphigoid: A Systematic Review and Meta-Analysis.

Ocul Immunol Inflamm

December 2024

Neuroscience (NEUROS) Research Group, Neurovitae Research Center, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.

Article Synopsis
  • - The study aimed to assess the frequency of eye-related symptoms in patients with mucous membrane pemphigoid through a systematic review and meta-analysis of existing literature.
  • - It analyzed data from 35 studies involving 1,439 patients, revealing that most affected individuals are women around 60 years old, with 90% experiencing bilateral eye issues, and highlighting trichiasis and entropion as the most common symptoms.
  • - The findings suggest that while severe complications like visual impairment are less common, they still require attention in patients suspected of having ocular manifestations of mucous membrane pemphigoid.
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Natural Language Processing in medicine and ophthalmology: A review for the 21st-century clinician.

Asia Pac J Ophthalmol (Phila)

September 2024

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore; Singapore Eye Research Institute, Singapore; Duke NUS Medical School, National University of Singapore, Singapore. Electronic address:

Article Synopsis
  • * In the medical sector, NLP can be used for tasks like extracting data from Electronic Health Records, aiding in clinical decisions, and analyzing medical images, although its real-world use is still limited.
  • * As large language models like ChatGPT are becoming more common, it's important for healthcare professionals to stay informed about how NLP technologies work, their benefits, and their limitations.
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Colombian ocular diseases epidemiology study (CODES): glaucoma incidence and sociodemographic characterisation 2015-2020.

Clin Exp Optom

July 2024

Neuroscience (NEUROS) Research Group, NeuroVitae Centre for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia.

Clinical Relevance: Glaucoma encompasses a group of eye diseases that progressively damage the optic nerve, leading to vision loss and blindness. Understanding the incidence and demographic distribution is vital for public health planning and patient care.

Background: Previous small-scale studies in Colombia have reported the prevalence of glaucoma in individuals over 40 years between 1.

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Managing a patient with uveitis in the era of artificial intelligence: Current approaches, emerging trends, and future perspectives.

Asia Pac J Ophthalmol (Phila)

September 2024

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Ophthalmology, Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore; Singapore Eye Research Institute, Singapore; Duke NUS Medical School, Singapore. Electronic address:

Article Synopsis
  • The integration of AI in healthcare is revolutionizing the management of complex conditions like uveitis, which requires specialized knowledge due to its various causes and treatment responses.
  • AI's potential in this field includes classifying diseases, analyzing imaging data, predicting outcomes, and identifying new treatments, addressing the shortage of uveitis specialists and improving patient care.
  • However, successfully applying AI in clinical settings faces challenges, such as the need for extensive datasets, transparency in algorithms, and real-world validation of these models.
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Clopidogrel is widely used worldwide as an antiplatelet therapy in patients with acute coronary disease. Genetic factors influence interindividual variability in response. Some studies have explored the polygenic contributions in the drug response, generating pharmacogenomic risk scores (PgxPRS).

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Background: In Colombia and worldwide, breast cancer (BC) is the most frequently diagnosed neoplasia and the leading cause of death from cancer among women. Studies predominantly involve hereditary and familial cases, demonstrating a gap in the literature regarding the identification of germline mutations in unselected patients from Latin-America. Identification of pathogenic/likely pathogenic (P/LP) variants is important for shaping national genetic analysis policies, genetic counseling, and early detection strategies.

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Coinfection Suspicion is Imperative in Immunosuppressed Patients with Suspected Infectious Uveitis and Inadequate Treatment Response: A Case Report.

Ocul Immunol Inflamm

December 2024

Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Background: To report a case of coinfection of (Tg) and (EBV) in a diabetic patient with rheumatoid arthritis and immunosuppressive biological therapy.

Case Presentation: A 70-year-old female with a history of rheumatoid arthritis on therapy with corticosteroids, methotrexate, and abatacept presented bilateral granulomatous panuveitis associated with retinal necrosis and macular involvement. A diagnostic vitrectomy detected Tg and EBV.

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Functional Analysis of 3'UTR Variants Predisposing to Breast Cancer.

Appl Clin Genet

May 2024

Center for Research in Genetics and Genomics (CIGGUR), Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad Del Rosario, Bogotá, Colombia.

Purpose: Breast Cancer (BC) is the main female cancer diagnosed worldwide, and it has been described that few genes, such as , have a high penetrance for this type of cancer. In this manuscript, we were interested in evaluating the effect of 3'UTR variants on BRCA1 expression.

Patients And Methods: To accomplish this objective, Whole Exome Sequencing (WES) data of 400 patients with unselected BC was used to filter variants located in the region of interest of gene, finding two of them (c.

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Infectious uveitis is a major global cause of vision impairment. Despite the eye's immune privilege, afforded by the blood-ocular barrier that restricts microbial entry, several pathogens such as bacteria, viruses, fungi, and parasites can still infiltrate and cause ocular infections and complications. Clinicians often encounter significant challenges in treating infectious uveitis due to limited or ineffective treatment options.

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Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders.

Ocul Immunol Inflamm

May 2024

Unit of Diagnostic Imaging, Department of Medical, Surgical and NeuroSciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy.

Article Synopsis
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Purpose: To describe the prevalence, incidence, and sociodemographic characterization of moderate to severe vision impairment (MSVI) and blindness in Colombia based on the National Health Registry Integrated Social Protection Information System (SISPRO) Database.

Methods: We performed a nationwide population-based study using SISPRO and the International Classification of Diseases. Total and new cases were identified to calculate the prevalence and incidence per 100,000 inhabitants of MSVI and blindness between 2015 and 2019.

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Coronavirus disease 2019 (COVID-19) was considered a major public health burden worldwide. Multiple studies have shown that susceptibility to severe infections and the development of long-term symptoms is significantly influenced by viral and host factors. These findings have highlighted the potential of host genetic markers to identify high-risk individuals and develop target interventions to reduce morbimortality.

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Background And Aim: Stem cell therapy is considered a promising treatment for several neurodegenerative diseases. However, there are very few studies on the use of this therapy in glaucoma models. By detecting the changes produced by glaucoma early, cell therapy could help prevent the events that lead to blindness.

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Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report.

Ocul Immunol Inflamm

November 2024

Ophthalmology Interest Group (OIG-UR), Neuroscience Research Group (NEUROS), Neurovitae Research Center, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To present an atypical case of severe bilateral ocular toxoplasmosis with systemic involvement that initially mimicked an autoimmune etiology, posing challenges to its diagnosis and treatment.

Case Report: A 39-year-old immunocompetent male was admitted to the hospital due to a presumed pulmonary thromboembolism concomitant with an abrupt onset of vision loss. Initial differential diagnoses included antiphospholipid syndrome and systemic lupus erythematosus, prompting the administration of corticosteroid pulses and rituximab.

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