136 results match your criteria: "Institute of Telese Terme[Affiliation]"

Reliable and valid metamemory measures are needed to assess subjective memory complaints that can be distinct from objective memory performance. The Multifactorial Memory Questionnaire (MMQ) evaluates dimensions of subjective memory functioning such as frequency of memory problems (Ability), affect related to memory abilities (Contentment), and strategy use in everyday life (Strategy). To examine the psychometric properties of the Italian version of the MMQ, six hundred Italian healthy individuals (aged 25-91 years) completed MMQ, a questionnaire assessing metacognition (Cognitive Failures Questionnaire, CFQ) and two batteries assessing cognitive global status (Montreal Cognitive Assessment, MoCA; Mini Mental State Examination, MMSE).

View Article and Find Full Text PDF

A clinical study on closing-in in focal brain-damaged individuals.

J Neurol Sci

April 2016

Neuropsychology Lab, Department of Psychology, Second University of Naples, Viale Ellittico 31, 81100 Caserta, Italy; Salvatore Maugeri Foundation, IRCCS, Rehabilitation Institute of Telese Terme (BN), Italy. Electronic address:

In visuo-constructional assessment, brain-damaged individuals may copy figures near to or superimposed on the model, showing the Closing-in (CI). CI has been largely investigated in dementia, and often ascribed to impairments of the attention/executive abilities ("Attraction hypothesis"). Only a few dated studies investigated frequency of CI in brain-damaged individuals, without clarifying the genesis of the phenomenon.

View Article and Find Full Text PDF

Hyper-aldosteronism is associated with myocardial dysfunction including induction of cardiac fibrosis and maladaptive hypertrophy. Mechanisms of these cardiotoxicities are not fully understood. Here we show that mineralocorticoid receptor (MR) activation by aldosterone leads to pathological myocardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death activity and GRK5 pro-hypertrophic action.

View Article and Find Full Text PDF

Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure.

Circ Res

April 2016

From the Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy (G.R., G.G., D.F.V., N.F.); Division of Geriatrics, Department of Translational Medical Sciences (G.R., G.P., G.D.F., V.P., A.C., D. Liccardo, K.K., G.G., M.L.D.'A., C.d.L., N.F., D. Leosco), Division of Cardiology, Department of Advanced Biomedical Sciences (P.P.F., B.T.), Federico II University of Naples, Naples, Italy; SDN Foundation IRCCS, Institute of Diagnostic and Nuclear Development, Naples, Italy (S.P.); and Department of Pharmacology, Center of Translational Medicine, Temple University, Philadelphia, PA (A.C., D. Liccardo, W.J.K.).

Rationale: Sympathetic nervous system hyperactivity is associated with poor prognosis in patients with heart failure (HF), yet routine assessment of sympathetic nervous system activation is not recommended for clinical practice. Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulated in HF patients, causing dysfunctional β-adrenergic receptor signaling. Importantly, myocardial GRK2 levels correlate with levels found in peripheral lymphocytes of HF patients.

View Article and Find Full Text PDF

Cutaneous sensory and autonomic denervation in CADASIL.

Neurology

March 2016

From the Neurology Department (M.N., V.P., G.C., A.S., F.C.), "Salvatore Maugeri" Foundation, IRCCS, Institute of Telese Terme; IRCCS Istituto delle Scienze Neurologiche (V.D., R.L.), Bologna; Molecular Medicine Laboratory (L.P.), Mazzoni Hospital, Ascoli Piceno; Department of Neurosciences, Reproductive Sciences and Odontostomatology (L.S.), University Federico II of Naples; and Division of Neurology (M.R.), Madonna del Soccorso Hospital, ASUR AV5, San Benedetto del Tronto, Italy.

Objective: To assess the involvement of the peripheral nervous system in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) by means of immunofluorescence and confocal analysis of punch skin biopsies.

Methods: We recruited 14 unrelated patients with CADASIL (M/F = 9/5; age 53.9 ± 10.

View Article and Find Full Text PDF

Introduction: Many literature data support the possibility of an increased cardiovascular (CV) risk in psoriatic arthritis (PsA) patients compared with the general population. This cannot be entirely explained by the presence of traditional vascular risk factors. It has been suggested that inflammation may act synergistically with traditional vascular risk factors, thus contributing to the atherosclerotic process and to the increased CV risk.

View Article and Find Full Text PDF

β Adrenergic Receptor Kinase C-Terminal Peptide Gene-Therapy Improves β2-Adrenergic Receptor-Dependent Neoangiogenesis after Hindlimb Ischemia.

J Pharmacol Exp Ther

February 2016

Division of Geriatrics, Department of Translational Medical Sciences, Federico II University of Naples, Italy (A.C., D.Li., G.G., M.L.D.A., D.Le., N.F., G.R.); Center for Translational Medicine, Temple University, Philadelphia, Pennsylvania (A.C., D.Li., W.J.K.); Department of Pharmaceutical Sciences, Nova Southeastern University College of Pharmacy, Fort Lauderdale, Florida (A.L.); Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme BN, Italy (F.R., G.R.).

After hindlimb ischemia (HI), increased catecholamine levels within the ischemic muscle can cause dysregulation of β2-adrenergic receptor (β2AR) signaling, leading to reduced revascularization. Indeed, in vivo β2AR overexpression via gene therapy enhances angiogenesis in a rat model of HI. G protein-coupled receptor kinase 2 (GRK2) is a key regulator of βAR signaling, and β adrenergic receptor kinase C-terminal peptide (βARKct), a peptide inhibitor of GRK2, has been shown to prevent βAR down-regulation and to protect cardiac myocytes and stem cells from ischemic injury through restoration of β2AR protective signaling (i.

View Article and Find Full Text PDF

GDAP1 mutations in Italian axonal Charcot-Marie-Tooth patients: Phenotypic features and clinical course.

Neuromuscul Disord

January 2016

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal-Infantile Sciences (DINOGMI), Medical Genetics, University of Genoa, Viale Benedetto XV, 16132, Genoa, Italy.

Mutations in the ganglioside-induced differentiation associated-protein 1 (GDAP1) gene have been associated with both autosomal recessive (AR) and dominant (AD) Charcot-Marie-Tooth (CMT) axonal neuropathy. The relative frequency of heterozygous, dominant mutations in Italian CMT is unknown. We investigated the frequency of dominant mutations in GDAP1 in a cohort of 109 axonal Italian patients by sequencing genomic DNA and search for copy number variations.

View Article and Find Full Text PDF

Cognitive dysfunctions in occipital lobe epilepsy compared to temporal lobe epilepsy.

J Neuropsychol

June 2017

Epilepsy Center, Department of Neuroscience, Reproductive and Odontostomatologic Sciences, University of Naples Federico II, Italy.

Objective: To compare cognitive profiles of occipital lobe epilepsy (OLE) and temporal lobe epilepsy (TLE) and to investigate whether impairment of visuospatial functions is a specific deficit of OLE.

Method: Eighteen patients with OLE, 18 patients with TLE, and 18 controls underwent a neuropsychological battery assessing memory, visuospatial functions, and frontal/executive functions.

Results: Multivariate analysis evidenced poorer performance of patients with TLE and patients with OLE relative to controls on tasks assessing verbal and non-verbal long-term memory, frontal functions, and visuospatial functions.

View Article and Find Full Text PDF

Charcot-Marie-Tooth disease: New insights from skin biopsy.

Neurology

October 2015

From the Departments of Neurosciences, Reproductive Sciences, and Odontostomatology (F.M., C.P., L.S.), University Federico II of Naples; Neurology Division (M.N., V.P., A.S., G.C.), "Salvatore Maugeri" Foundation, Institute of Telese Terme; the Department of Neurological and Movement Sciences, University of Verona (G.M.F.), and the Department of Neurosciences, AOUI Verona (T.C.), University Hospital G.B. Rossi, Verona, Italy; and the Department of Neurology (M.E.S.), University of Iowa Hospitals and Clinics, Iowa City.

Objective: To evaluate, by skin biopsy, dermal nerve fibers in 31 patients with 3 common Charcot-Marie-Tooth (CMT) genotypes (CMT1A, late-onset CMT1B, and CMTX1), and rarer forms of CMT caused by mutations in RAB7 (CMT2B), TRPV4 (CMT2C), and GDAP1 (AR-CMT2K) genes.

Methods: We investigated axonal loss by quantifying Meissner corpuscles and intrapapillary myelinated endings and evaluated morphometric changes in myelinated dermal nerve fibers by measuring fiber caliber, internodal, and nodal gap length.

Results: The density of both Meissner corpuscles and intrapapillary myelinated endings was reduced in skin samples from patients with CMT1A and all the other CMT genotypes.

View Article and Find Full Text PDF

We investigated the agreement between simple indirect immunofluorescence (IF) and bright-field immunohistochemistry (BFI) on free-floating sections for intraepidermal nerve fiber density (IENFD) quantification. Fifty-five healthy subjects and 63 patients with probable small fiber neuropathy (SFN) underwent two adjacent skin biopsies at the distal leg processed by IF and BFI technique. Agreement between IENFD pairs obtained by each method was assessed by Bland-Altman testing.

View Article and Find Full Text PDF

Subclinical Hypothyroidism and Cognitive Impairment: Systematic Review and Meta-Analysis.

J Clin Endocrinol Metab

November 2015

Geriatrics Unit (G.Pas., F.M.), Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy; King's College London (G. Pag.), Department of Clinical Neuroscience, London, United Kingdom; Department of Translational Medical Sciences (G.Pag., G.R., N.F.), Federico II University of Naples, Naples, Italy; and Salvatore Maugeri Foundation (G.R., N.F.), IRCCS Institute of Telese Terme, Benevento, Italy.

Background: The association between subclinical hypothyroidism (sHT) and cognitive impairment or risk of dementia is not well-defined, especially in the elderly, where the assessment of central nervous system function is challenging. The aim of this systematic review and meta-analysis was to evaluate the possible effect of sHT on cognitive decline and the risk of dementia.

Methods: Cognitive function was the primary outcome, evaluated as composite endpoint of incidence or prevalence of dementia or difference of Mini Mental State Examination, Wechsler Adult Intelligence Scale, and Wechsler Memory Scale-Revised scores.

View Article and Find Full Text PDF

Postherpetic neuralgia (PHN) is a common and exceptionally drug-resistant neuropathic pain condition. In this cross-sectional skin biopsy study, seeking information on the responsible pathophysiological mechanisms we assessed how ophthalmic PHN affects sensory and autonomic skin innervation. We took 2-mm supraorbital punch skin biopsies from the affected and unaffected sides in 10 patients with ophthalmic PHN.

View Article and Find Full Text PDF

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by ossification of different entheses. Psoriatic arthritis (PsA) is a seronegative spondyloarthritis associated with psoriasis. Given the possible overlap of the two diseases, we assessed whether DISH presence may affect PsA clinical outcomes.

View Article and Find Full Text PDF

The closing-in phenomenon in Parkinson's disease.

Parkinsonism Relat Disord

July 2015

Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy; IDC Hermitage-Capodimonte, Naples, Italy. Electronic address:

Introduction: Closing-in (CI) is a peculiar phenomenon consisting in the tendency to copy drawings close to or superimposed on a model. Recent findings showed that CI can be associated with frontal/executive dysfunctions, likely determining a failure in high-level monitoring of attention-action circuits. CI has been often observed in demented patients, but scarce data are available about CI in patients with Parkinson's disease (PD).

View Article and Find Full Text PDF

Insulin resistance is associated with impaired cardiac sympathetic innervation in patients with heart failure.

Eur Heart J Cardiovasc Imaging

October 2015

Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University, Naples, Italy

Aims: Insulin resistance (IR) represents, at the same time, cause and consequence of heart failure (HF) and affects prognosis in HF patients, but pathophysiological mechanisms remain unclear. Hyperinsulinemia, which characterizes IR, enhances sympathetic drive, and it can be hypothesized that IR is associated with impaired cardiac sympathetic innervation in HF. Yet, this hypothesis has never been investigated.

View Article and Find Full Text PDF

Ankylosing spondylitis and posture control: the role of visual input.

Biomed Res Int

December 2015

Rheumatology and Rehabilitation ResearchUnit, "Salvatore Maugeri" Foundation I.R.C.C.S., Scientific Institute of Telese Terme, Via Bagni Vecchi 1, 82037 Telese Terme, Italy ; Rehabilitation Research Unit, "Salvatore Maugeri" Foundation I.R.C.C.S., Scientific Institute of Cassano delle Murge, Via Mercadante 2, 70020 Cassano delle Murge, Italy.

Objectives: To assess the motor control during quiet stance in patients with established ankylosing spondylitis (AS) and to evaluate the effect of visual input on the maintenance of a quiet posture.

Methods: 12 male AS patients (mean age 50.1 ± 13.

View Article and Find Full Text PDF

MicroRNAs (miRNAs) are small non-coding RNA which have been shown to regulate gene expression. The alteration ofmiRNAs expression has been associated with several pathological processes, including neurodegeneration. In the search for easily accessible and non-invasive biomarkers for Alzheimer's disease (AD) diagnosis and prognosis, circulating miRNAs are among the most promising candidates.

View Article and Find Full Text PDF

Differential trigeminal myelinated and unmyelinated nerve fiber involvement in FOSMN syndrome.

Neurology

February 2015

From University Sapienza (A.T., A.B., G.A., G.C.), Rome; "Salvatore Maugeri" Foundation (V.P., A.S., M.N.), Institute of Telese Terme (BN), and University Federico II of Naples (L.S.), Naples, Italy.

View Article and Find Full Text PDF

Background: Diabetes mellitus (DM) is associated with impaired prognosis in patients with heart failure (HF), but pathogenic mechanisms are unclear. In the failing heart, elevated β-adrenergic receptor (β-AR) activation by catecholamines causes G-protein-coupled receptor kinase-2 (GRK2) upregulation which is responsible for β-AR signalling dysfunction. Importantly, GRK2 expression, measured in peripheral lymphocytes of HF patients, correlates with levels of this kinase in the failing myocardium reflecting the loss of hemodynamic function.

View Article and Find Full Text PDF

Small nerve fiber involvement in CMT1A.

Neurology

January 2015

From the Neurology Division (M.N., V.P., A.S., G.C.), "Salvatore Maugeri" Foundation, Institute of Telese Terme; the Department of Neurosciences, Reproductive and Odontostomatological Sciences (F.M., C.P., R.I., L.S.), University Federico II of Naples, Italy; and the Department of Neurology (M.E.S.), University of Iowa, Iowa City.

Objective: To assess the involvement of small nerve fibers in Charcot-Marie-Tooth type 1A (CMT1A).

Methods: We used indirect immunofluorescence and confocal microscopy on punch biopsies from glabrous (fingertip) and hairy (thigh and leg) skin of 20 unrelated patients with CMT1A to quantify somatic and autonomic nerve fibers. In particular, we quantified epidermal nerve fibers (ENF), Meissner corpuscles (MC), intrapapillary myelinated endings (IME), and sudomotor nerves.

View Article and Find Full Text PDF

Background: Apathy is defined as lack of motivation affecting cognitive, emotional, and behavioral domains and is usually assessed by standardized scales, such as the Apathy Evaluation Scale (AES). Recently, apathy has been recognized as a frequent behavioral symptom in multiple sclerosis (MS).

Objective: To evaluate applicability and clinical-metric properties of AES in MS and the agreement between patients' and caregivers' evaluation of apathy.

View Article and Find Full Text PDF

A multicentre study of intentional behavioural responses measured using the Coma Recovery Scale-Revised in patients with minimally conscious state.

Clin Rehabil

August 2015

Lab. for the study of Disorders of Consciousness, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Italy Neuropsychology Lab, Department of Psychology, Second University of Naples, Caserta, Italy.

Objective: To investigate which conscious behaviour is most frequently detected using the Coma Recovery Scale-Revised in patients with minimally conscious state.

Design: Multicentre, cross-sectional study.

Setting: One intensive care unit, 8 post-acute rehabilitation centres and 2 long-term facilities.

View Article and Find Full Text PDF