Performance Assessment of Large Language Models in Medical Consultation: A Comparative Study.

Background: The recent introduction of generative artificial intelligence (AI) as an interactive consultant has prompted an interest in assessing its applicability in medical discussions and consultations, particularly in the domain of depression.

Objective: This study assessed the capability of Large Language Models (LLMs) in AI to generate responses to depression-related queries.

Methods: Utilizing the PubMedQA and QuoraQA datasets, we compared various LLMs, such as BioGPT, PMC-Llama, GPT-3.

Exponentially Enhanced Scheme for the Heralded Qudit Greenberger-Horne-Zeilinger State in Linear Optics.

High-dimensional multipartite entanglement plays a crucial role in quantum information science. However, existing schemes for generating such entanglement become complex and costly as the dimension of quantum units increases. In this Letter, we overcome the limitation by proposing a significantly enhanced linear optical heralded scheme that generates the d-level N-partite Greenberger-Horne-Zeilinger (GHZ) state with single-photon sources and linear operations.

Analysis of bottleneck technology identification and development characteristics in the electronic manufacturing industry.

In 2018, US government imposed a ban on Chinese electronics firm ZTE, prohibiting it from procuring chip products from American companies for a duration of seven years. Subsequently, ZTE experienced a shutdown. The concept of "bottleneck technology" gained prominence in diverse media outlets.

Gaps between Open Science activities and actual recognition systems: Insights from an international survey.

There are global movements aiming to promote reform of the traditional research evaluation and reward systems. However, a comprehensive picture of the existing best practices and efforts across various institutions to integrate Open Science into these frameworks remains underdeveloped and not fully known. The aim of this study was to identify perceptions and expectations of various research communities worldwide regarding how Open Science activities are (or should be) formally recognised and rewarded.

Characteristics and community stabilities of the resource islands formed by shrubs in the mobile sandy land of the upper reaches of the Yellow River in Sichuan Province.

This study comprehensively analyzes the physical and chemical properties of soil across different layers under shrubs, comparing these properties inside and outside the shrub canopies. It also examines species diversity and community stability in these areas, discussing the impact of soil from resource islands at different formation stages on vegetation restoration. Focusing on shrubs over varying restoration periods (45 years, 25 years, and 13 years), with unrepaired mobile sandy land serving as the control, the results are as follows: (1) As vegetation restoration progresses, the content of soil organic matter (SOM) and alkali-hydrolyzable nitrogen (AN) significantly increase.

Quantum game strategy solution for R&D cartel: Reorganizing government R&D investment strategy in Korea.

This study reevaluates criticism of the Korean government's R&D investment strategy, which was considered an 'R&D cartel' and was cited as a reason for the Korean government's R&D cuts in 2023, through an advanced framework of quantum game theory. By modeling the interaction between the government and researchers as a quantum information strategy game, it redefines the dynamics of R&D investment as a quantum game involving two key players: the R&D manager (Alice) and the research performer (Bob). This quantum game, akin to the Prisoner's Dilemma but focused on responsibility and sincerity, allows for the exploration of strategic complexities and decision-making dynamics not possible in classical models.

A practical approach to multifaceted perspectives for sustainable international collaboration on mosquito-borne diseases in Southeast Asia.

The coronavirus disease 2019 pandemic highlighted the necessity and limitations of scientific collaboration and equitable and effective international research partnerships. The spread of mosquito-borne diseases (MBDs) presents severe public health challenges, particularly in Southeast Asia. Addressing these threats requires establishing regional priorities, bridging research gaps, and strengthening long-term international collaboration.

Compaction and clustering of a heterogeneous polymer by biomolecular crowding.

Inspired by bacterial chromosome organization, we study the compaction and clustering of a heterogeneous ring polymer in a crowded medium using molecular dynamics simulations. The polymer consists of several large monomers interspersed along the backbone and small intervening monomers. In a crowded medium, the entropy of crowding particles or crowders favors the collapse of chain molecules, such as chromosomes.

Shank3 Overexpression Leads to Cardiac Dysfunction in Mice by Disrupting Calcium Homeostasis in Cardiomyocytes.

Background And Objectives: SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins play crucial roles as neuronal postsynaptic scaffolds. Alongside neuropsychiatric symptoms, individuals with mutations often exhibit symptoms related to dysfunctions in other organs, including the heart. However, detailed insights into the cardiac functions of Shank3 remain limited.

The impact of sex/gender-specific funding and editorial policies on biomedical research outcomes: a cross-national analysis (2000-2021).

Reflecting sex and gender characteristics in biomedical research is critical to improving health outcomes and reducing adverse effects from medical treatments. This study investigates the impact of sex/gender-specific funding policies and journal editorial standards on the integration of sex/gender analysis in biomedical research publications. Using data from the United States, Canada, the United Kingdom, and other countries between 2000 and 2021, we assessed how these policies influenced research output in the fields of medicine and life sciences.

Kinetics of Polyampholyte Dimerization: Influence of Charge Sequences.

Polyampholytes (PAs) exhibit complex behaviors in various environments influenced by their charge distribution. This study focuses on the kinetics of dimerization of PAs, aiming to elucidate the underlying mechanisms and clarify relevant characteristics of the charge sequence. We focus on PAs with non-zero net charges, employing molecular dynamics simulations and theoretical analyses to examine how charge sequences influence the rates of dimer formation and dissociation.

ELiAH: the atlas of E3 ligases in human tissues for targeted protein degradation with reduced off-target effect.

The development of therapeutic agents has mainly focused on designing small molecules to modulate target proteins or genes which are conventionally druggable. Therefore, targeted protein degradation (TPD) for undruggable cases has emerged as promising pharmaceutical approach. TPD, often referred PROTACs (PROteolysis TArgeting Chimeras), uses a linker to degrade target proteins by hijacking the ubiquitination system.

The hallmarks of tissue-agnostic therapies and strategies for early anticancer drug discovery.

Recently, precision medicine has enabled biomarker-driven treatment to be administered in a pan-tumor setting, so-called tissue-agnostic therapy. This represents a paradigm shift in cancer care from conventional cancer type-specific to biomarker-centric care, where patients are selected for this type of therapy based on molecular aberrations that occur across cancer types, regardless of tumor site or histology. This approach is particularly important because it offers new treatment options for patients with rare cancers or for whom there are no adequate treatments.

Lutein inhibits glutamate-induced apoptosis in HT22 cells via the Nrf2/HO-1 signaling pathway.

Introduction: Excessive glutamate levels induce oxidative stress, resulting in neuronal damage, and cell death. While natural antioxidants show promise for neuroprotection, their effectiveness in the central nervous system (CNS) is limited by the blood -brain barrier. Lutein, a neuroprotective carotenoid, has gained attention for its ability to traverse this barrier and accumulate in various brain regions.

Comparison of the Performance of ChatGPT, Claude and Bard in Support of Myopia Prevention and Control.

Purpose:  Chatbots, which are based on large language models, are increasingly being used in public health. However, the effectiveness of chatbot responses has been debated, and their performance in myopia prevention and control has not been fully explored. This study aimed to evaluate the effectiveness of three well-known chatbots-ChatGPT, Claude, and Bard-in responding to public health questions about myopia.

Characterization and source apportionment of pharmaceuticals in surface water of the Yangtze Estuary and adjacent sea.

Pharmaceuticals, which are closely linked to human activities, have attracted global attention. This study investigated the occurrence characteristics of 20 pharmaceuticals in surface water of the Yangtze Estuary and adjacent sea. A total of 14 targeted pharmaceuticals were detected in both spring and summer sampling campaigns.

Low-level brain somatic mutations in exonic regions are collectively implicated in autism with germline mutations in autism risk genes.

Low-level somatic mutations in the human brain are implicated in various neurological disorders. The contribution of low-level brain somatic mutations to autism spectrum disorder (ASD), however, remains poorly understood. Here, we performed high-depth exome sequencing with an average read depth of 559.

Observation of Medium-Induced Yield Enhancement and Acoplanarity Broadening of Low-p_{T} Jets from Measurements in pp and Central Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

The ALICE Collaboration reports the measurement of semi-inclusive distributions of charged-particle jets recoiling from a high transverse momentum (high p_{T}) hadron trigger in proton-proton and central Pb-Pb collisions at sqrt[s_{NN}]=5.02  TeV. A data-driven statistical method is used to mitigate the large uncorrelated background in central Pb-Pb collisions.

Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton.

De novo variants in the Cytoplasmic FMR1-interacting protein 2 (CYFIP2) have been repeatedly associated with neurodevelopmental disorders and epilepsy, underscoring its critical role in brain development and function. While CYFIP2's role in regulating actin polymerization as part of the WAVE regulatory complex (WRC) is well-established, its additional molecular functions remain relatively unexplored. In this study, we performed unbiased quantitative proteomic analysis, revealing 278 differentially expressed proteins (DEPs) in the forebrain of Cyfip2 knock-out embryonic mice compared to wild-type mice.

Improving grassland ecosystem services for human wellbeing in the karst desertification control area: Anthropogenic factors become more important.

Elucidating the spatial and temporal patterns of grassland ecosystem service value (ESV) changes under different karst geomorphic types (KGTs) is crucial for promoting regional sustainable development and enhancing human well-being. Karst ecosystems are characterized by high spatial heterogeneity. However, analyses of the drivers of spatial and temporal changes in ESV in karst grasslands at multiple scales are lacking.

Photoproduction of K^{+}K^{-} Pairs in Ultraperipheral Collisions.

K^{+}K^{-} pairs may be produced in photonuclear collisions, either from the decays of photoproduced ϕ(1020) mesons or directly as nonresonant K^{+}K^{-} pairs. Measurements of K^{+}K^{-} photoproduction probe the couplings between the ϕ(1020) and charged kaons with photons and nuclear targets. The kaon-proton scattering occurs at energies far above those available elsewhere.