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Femoral cartilage defects initiate from medial meniscus extrusion or tibial cartilage lesions and expand in knee osteoarthritis as revealed by 3D MRI analysis.
Sci Rep
October 2024
Center for Stem Cell and Regenerative Medicine, Institute of Science Tokyo (Formerly Tokyo Medical and Dental University, renamed on October 1, 2024), 1-5-45 Yushima, Bunkyo-Ku, Tokyo, 113-8510, Japan.
Article Synopsis
- Knee osteoarthritis leads to wear in the articular cartilage, but the details of how this progresses are still unclear.
- This study focused on 17 knees from a group of 277 women to investigate factors affecting cartilage defects in the femur, especially in relation to the menisci and tibial cartilage lesions.
- Findings showed that defects were often linked to medial meniscus issues and tibial cartilage degeneration, particularly in older individuals, highlighting complex interactions that worsen cartilage health over time.