12 results match your criteria: "Institute of Safety Research[Affiliation]"
Rev Sci Instrum
January 2010
Institute of Safety Research, Forschungszentrum Dresden-Rossendorf, 01328 Dresden, Germany.
In this paper, a thermal control design for a high-resolution gamma-ray computed tomography detector is presented. It accounts for the generation of heat produced by active electronic components as well as heat transfer from external heat sources. The development and implementation of this feature were motivated by stringent requirements for measurement accuracy at thermal hydraulic test facilities, where ambient thermal conditions are constantly changing.
View Article and Find Full Text PDFRev Sci Instrum
October 2007
Institute of Safety Research, Forschungszentrum Dresden-Rossendorf e.V., P.O. Box 51 01 19, 01314 Dresden, Germany.
We report on the development of a high resolution gamma ray tomography scanner that is operated with a Cs-137 isotopic source at 662 keV gamma photon energy and achieves a spatial image resolution of 0.2 line pairs/ mm at 10% modulation transfer function for noncollimated detectors. It is primarily intended for the scientific study of flow regimes and phase fraction distributions in fuel element assemblies, chemical reactors, pipelines, and hydrodynamic machines.
View Article and Find Full Text PDFSensors (Basel)
October 2007
Forschungszentrum Dresden-Rossendorf e.V., Institute of Safety Research, PO Box 510119, D-01314 Dresden, Germany.
A novel planar array sensor based on electrical conductivity measurements ispresented which may be applied to visualize surface fluid distributions. The sensor ismanufactured using printed-circuit board fabrication technology and comprises of 64 x 64interdigital sensing structures. An associated electronics measures the electricalconductivity of the fluid over each individual sensing structure in a multiplexed manner byapplying a bipolar excitation voltage and by measuring the electrical current flowing from adriver electrode to a sensing electrode.
View Article and Find Full Text PDFJ Contam Hydrol
March 2007
Research Centre Rossendorf, Institute of Safety Research, PO Box 510119, 01314 Dresden, Germany.
A successful application of reaction transport algorithms to calculate the chemical evolution of natural systems requires accurate methods to compute the rates of mineral/fluid surface reactions. Regarding the transport of radio-nuclides in mining dumps the dissolution of minerals is of special importance. Using a kinetic rate law of the mineral dissolution verified for unsaturated conditions will allow a realistic modelling of the mineral weathering in the environment.
View Article and Find Full Text PDFJ Toxicol Sci
July 1998
Fukui Institute of Safety Research, ONO Pharmaceutical Co., Ltd., Japan.
A 6-month repeated dose toxicity study with 1-month recovery test of sodium N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino] benzoyl] aminoacetate tetrahydrate (ONO-5046.Na), a novel neutrophil elastase inhibitor, was conducted in Sprague-Dawley (SD) rats. The rats of both sexes were administered ONO-5046.
View Article and Find Full Text PDFVet Hum Toxicol
December 1995
Department of Toxicology, National Institute of Safety Research, Seoul, Korea.
N-butyl benzenesulfonamide (NBBS), one of the sulfonamide plasticizers, induced characteristic effects to Wistar rats after acute repeated exposures (300 mg/kg body weight, ip every 6 h). The signs were pica, staggering gait with hindlimb-paresis and splaying, teeth-grinding, self paw-biting and coma. The motor activity parameters showed generalized decreased mobility.
View Article and Find Full Text PDFJpn J Cancer Res
June 1994
Department of Pathology, National Institute of Safety Research, Seoul, Korea.
The biphasic modifying effects of indole-3-carbinol (I3C), a naturally occurring constituent of edible cruciferous vegetables, on the development of glutathione S-transferase placental form (GST-P)-positive liver cell foci were investigated by using a medium-term liver bioassay system and a newborn rat hepatocarcinogenesis system. In Experiment 1, a total of 65 male Sprague-Dawley (SD) rats were divided into 5 groups. Animals were given a single intraperitoneal (i.
View Article and Find Full Text PDFCancer Lett
November 1993
Department of Toxicology, National Institute of Safety Research, Seoul, Korea.
A form of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), was comparatively determined for 48 h in the kidney and liver isolated from Sprague-Dawley rats i.p. treated with Adriamycin; potassium bromate (KBrO3), hydroquinone and vitamin A.
View Article and Find Full Text PDFSelectivity of lead effect on dopamine beta-hydroxylase activity in regions of brai nfrom rats postnatally exposed to lead was tested. Three groups of animals were prepared; (1) Rats exposed to lead at a low dose (0.05% PbAcetate: PbAc); (2) Rats exposed to lead at a high dose (0.
View Article and Find Full Text PDFSelectivity of lead effect to phenylethanolamine N-methyltransferase (PNMT) activity in regions of brain from rats postnatally exposed to lead was tested. Three groups of animals were prepared; (1) Rats exposed to lead at a low dose (0.05% PbAcetate: PbAc); (2) Rats exposed to lead at a high dose (0.
View Article and Find Full Text PDFJ Toxicol Sci
November 1992
National Institute of Safety Research, Seoul National University, Korea.
Alterations of tyrosine hydroxylase activity in various regions of brain from rats postnatally exposed to lead were tested. Three groups of animals were prepared; (1) Rats exposed to lead at a low dose (0.05% lead acetate, PbAc); (2) Rats exposed to lead at a high dose (0.
View Article and Find Full Text PDFJ Toxicol Sci
February 1991
Department of Toxicology, National Institute of Safety Research, Seoul, Korea.
Pregnant Wistar rats were given daily subcutaneous administrations of methamphetamine (MAPT; varying doses ranging from 1.0 to 4.5 mg/kg) from days 7 to 20 of gestation and teratogenic effects have been determined.
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