First molecular characterisation of in a pig carcass condemned during routine meat inspection in Poland.

Introduction: This article presents the fourth detection of macroscopic cystic lesions due to sarcocystosis in domestic pigs during routine meat inspection worldwide, and the first molecular detection of in a domestic pig in Poland. Pigs can become intermediate hosts for by accidental ingestion of oocysts or sporocysts present in food or water contaminated by the faeces of canids (definitive hosts).

Material And Methods: The affected swine showed no clinical symptoms such as weight loss, dermatitis or dyspnoea suggesting sarcocystosis.

'Do they care?': a qualitative examination of patient perspectives on primary care clinician communication related to opioids in the USA.

Objectives: This substudy's objectives were to (1) examine the transferability of a four archetype framework (simplified pattern of prototypical features) for patients at high risk for opioid use disorder (OUD) developed from a previous study with a similar population; (2) explore how patient preferences for terminology can inform clinician communication strategies for patients with OUD across archetypes and (3) explore how patient perceptions of opioid risks can inform clinician communication strategies across patient archetypes.

Design: This qualitative study collected data via semistructured phone interviews with patients about views on opioid-related discussions with primary care clinicians. Qualitative data were coded using the Rigorous and Accelerated Data Reduction technique and analysed via iterative inductive/deductive thematic analysis.

in Sewage Sludge and Digestate Intended for Soil Fertilization.

Substances of organic origin are seeing increasing use in agriculture as rich sources of nutrients for plants. The aim of this study was to determine the microbiological contamination of sewage sludge and digestate to assess their safe use as fertilizers in Poland. The assessment of microbial soil, sewage sludge and digestate contamination was based on the total number of mesophilic bacteria and Gram-negative bacteria from the family.

Advances in Nanotheranostic Systems for Concurrent Cancer Imaging and Therapy: An Overview of the Last 5 Years.

The rapid development of nanotechnology during the last two decades has created new opportunities to design and generate more advanced nanotheranostics with diversified capabilities for diagnosis, drug delivery, and treatment response monitoring in a single platform. To date, several approaches have been employed in order to develop nanotheranostics. The purpose of this review is to briefly discuss the key components of nanotheranostic systems, to present the conventional and upcoming imaging and therapeutic modalities that employ nanotheranostic systems, and to evaluate recent progress in the field of cancer nanotheranostic systems in the past five years (2020-2024).

Prevalence of in sprouts and vegetable mixtures and salads sold in retail shops in Lublin, eastern Poland - preliminary study.

Introduction: In 2022-2023, examinations were carried out for the presence of a pathogenic bacterium in ready-to-eat (RTE) vegetable products (sprouts and vegetable mixtures and salads) sold for immediate consumption in retail shops located in Lublin, eastern Poland. The identification of strains were performed according to the Polish Standard and accomplished with the Microgen Listeria-ID System.

Results: A high prevalence of infections was found in the unprocessed sprouts of plants belonging to the cabbage (Brassicaceae) family - kale (30.

Absence of spp. in ixodid ticks collected from vegetation and animals in eastern Poland.

Introduction And Objective: Parasites of the genus are intracellular protozoa that infect the leukocytes and erythrocytes of animals, causing theileriosis. The aim of the study was to examine the presence of spp. in adult ticks and their offspring in the Lublin region of eastern Poland.

Rehabilitation - definition for research purposes.

Introduction And Objective: The Rehabilitation Definition for Research Purposes (RDRP), published in 2022 by Cochrane Rehabilitation, addresses discrepancies resulting from the multiplicity and heterogeneity of rehabilitation definitions hitherto used in the contexts of science, health, and social/legal aspects. The RDRP, based on the paradigm of the International Classification of Functioning, Disability, and Health, provides clear-cut criteria for what rehabilitation includes and excludes. The final version of the RDRP achieved brad agreement among global stakeholders.

Dietary patterns in people with mild cognitive impairment.

Introduction And Objective: Dietary habits may be an essential modulator affecting diet-related cognitive decline. One hopes that their identification will allow opening the use of new approaches for the management of the prevention and treatment of patients with mild cognitive disorders and maintaining a good quality of life. The aim of the research was to characterize dietary habits in people with mild cognitive impairment (MCI).

Effect of COVID-19 pandemic on health behaviours of students of medical specialities from the aspect of psychological support based on a Polish example.

Introduction And Objective: The aim of the study was to evaluate the effect of the COVID-19 pandemic on health behaviours of students of medical specialities from the aspect of psychological support in Poland.

Material And Methods: A study was conducted from 6 June - 16 December, 2022 among students of the Collegium Medicum at the Jan Kochanowski University in Kielce (CM UJK), Poland, and the Medical University of Warsaw (WUM). The final analysis covered 517 students of full-time studies - 265 (51.

Influence of bee venom on antinociceptive activity of selected analgesic drugs in hot plate test in mice.

Introduction And Objective: The aim of the study was to investigate the effect of bee venom on the activity of two analgesics: ketoprofen (a non-steroidal anti-inflammatory drug) and tramadol (an opioid drug) in the acute thermal pain model (hot-plate test) in mice.

Material And Methods: Linear regression analysis was used to evaluate the dose-response relationship between logarithms of drug doses and their resultant maximum possible anti-nociceptive effects in the mouse hot-plate test. Doses that increased the anti-nociceptive effect by 20% (ED values) for bee venom, ketoprofen and tramadol, and their combination were calculated from linear equations.

Temperature as a determining factor in the occurrence of Legionella sp. bacteria in hot water systems in hospitals and social welfare homes.

Introduction And Objective: Water in installations in hospitals and social welfare homes (SWHs) should meet the requirements of the Directive of the European Parliament and of the Council on the quality of water intended for human consumption and national regulations issued on its basis. At present, 60 species of bacteria of the genus Legionella sp. are known (of which 30 are considered as pathogenic for humans), and more than 80 serologic groups.

Strategies for coping with stress, emotional control and occupational burnout among surgical nurses.

Introduction And Objective: Nursing staff constitute 59% of the total number of health care workers worldwide - a total of 27.9 million people. The aim of the study is assessment of the prevalence of stress, including strategies for coping with stress, emotional control, and occupational burnout syndrome, as well as the effect of chronic stress on occupational burnout among surgical nurses.

The GPR39 Receptor Plays an Important Role in the Pathogenesis of Overactive Bladder and Corticosterone-Induced Depression.

Despite the close and clinically confirmed association between depression and overactive bladder, it remains unclear whether this affective disorder is a factor causing overactive bladder or whether overactive bladder is a specific symptom of psychosomatic disorders. This study examined the effects of repeated corticosterone administration on the occurrence of symptoms associated with depression and overactive bladder. Additionally, we examined whether administering TC-G 1008, an antidepressant that selectively activates the GPR39 receptor, could alleviate corticosterone-induced depression-like behavior and detrusor overactivity-related changes in cystometric measurements.

Transovarial transmission of Rickettsia spp., Francisella-like endosymbionts, and Spiroplasma spp. in Dermacentor reticulatus ticks.

Research on the transovarial transmission of pathogens whose reservoirs and vectors are ticks has led to an understanding of the mechanisms related to the circulation and persistence of selected microorganisms in natural foci. The primary aim of this study was to investigate the possibility of transovarial transmission of Rickettsia spp. in Dermacentor reticulatus ticks, and the influence of Francisella-like endosymbionts (FLEs) and Spiroplasma spp.

Cardiometabolic Risk in Pediatric Patients with Intellectual and Developmental Disabilities.

Introduction: Intellectual and Developmental Disabilities (IDD) have been associated with high cardiometabolic risk in adults, but there is little data on youth. This study describes the prevalence of cardiometabolic risk factors among pediatric patients with and without IDD receiving care in a large, primarily rural health system.

Methods: This was a retrospective cohort study of patients aged 6-17 years with an index visit from August 1, 2022, to July 31, 2023, at one of 44 primary care clinics in a Midwestern health system.

Pharmacist-led Transitions of Care: A Cohort Study on Admission Medication History Factors and Adjustments to the Discharge Medication List.

Patients are at risk of experiencing medication errors during each transition of care (TOC), which can result in adverse drug events and readmissions. Implementing a pharmacist-led TOC service can optimize medication safety and patient outcomes by identifying and correcting medication discrepancies prior to hospital discharge. A pharmacist-led TOC service at a tertiary care center expanded services to review medications at discharge for all enrolled hospitalized patients, but data collection and review had yet to be performed.

Hospitalizations and deaths among people coinfected with HIV and HCV.

Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) remains a significant public health challenge. This retrospective, population-based study assessed the trends in hospitalization rates among patients co-infected with HCV and HIV in Poland in 2012-2022, encompassing the COVID-19 pandemic and massive influx of war refugees from Ukraine, the demographics and clinical characteristics among hospitalized patients, including in-hospital case fatality rates. Most hospitalized patients were over 40 years old (mean ± SD: 41.

HLA-G can be transfered via trogocytosis from leukemic cells to T cells in chronic lymphocytic leukemia.

In chronic lymphocytic leukemia (CLL) immune escape mechanism allows leukemia cells to proliferate and expand and it might also be responsible for disease progression. Some molecules involved in the regulation of an immune system might represent prognostic value for CLL patients. Among numerous immune escape mechanisms it was shown that the expression of human leukocyte antigen G (HLA-G) might represent one of the agents damaging cellular immune response.

The engagement of Ras/Raf/MEK/ERK and PLCγ1/PKC pathways regulated by TrkB receptor in resistance of glioma cells to elimination upon apoptosis induction.

The most aggressive tumors of human central nervous system are anaplastic astrocytoma (AA, III grade) and glioblastoma multiforme (GBM, IV grade) with an extremely bad prognosis. Their malignant character and resistance to standard therapy are correlated to the over-expression of survival pathways such as Ras/Raf/MEK/ERK and PLCγ1/PKC regulated by TrkB receptor. Therefore, the aim of this study was to investigate the engagement of those pathways in human glioma cells resistance for apoptosis induction by Temozolomide treatment.

Hospitalizations of Patients with Atrial Fibrillation (AF) in Poland: A Nationwide Study Based on over One Million AF Hospitalizations in 2017-2021.

Atrial fibrillation (AF) is one of the most common forms of persistent arrhythmia in adults worldwide. The aim of this study was to present recent data on the epidemiology of patients hospitalized with AF in Poland. This is a retrospective, population-based study conducted using hospital discharge records.

Enhancement of Glutamate Uptake as Novel Antiseizure Approach: Preclinical Proof of Concept.

Objective: Excitotoxicity is a common hallmark of epilepsy and other neurological diseases associated with elevated extracellular glutamate levels. Thus, here, we studied the protective effects of (R)-AS-1, a positive allosteric modulator (PAM) of glutamate uptake in epilepsy models.

Methods: (R)-AS-1 was evaluated in a range of acute and chronic seizure models, while its adverse effect profile was assessed in a panel of standard tests in rodents.

Hyperbaric Treatment Stimulates Chaperone-Mediated Macroautophagy and Autophagy in the Liver Cells of Healthy Female Rats.

The role of autophagy goes far beyond the elimination of damaged cellular components and the quality control of proteins. It also cleanses cells from inclusions, including pathogenic viruses, and provides energy-forming components. The liver, which is an organ with increased metabolism, is made up of cells that are particularly vulnerable to damage.