7 results match your criteria: "Institute of Ruhr University Bochum (IPA)[Affiliation]"
Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study.
J Occup Med Toxicol
September 2020
Centre of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Background: A two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed to high solar UV radiation compared to controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the risk estimates.
Objectives: To evaluate the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure.
Occupational UV-Exposure is a Major Risk Factor for Basal Cell Carcinoma: Results of the Population-Based Case-Control Study FB-181.
J Occup Environ Med
January 2018
Center of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Dr Schmitt, Dr Haufe, Trautmann, Stange); Institute and Outpatient Clinics of Occupational and Social Medicine, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Drs Haufe, Andreas Seidler); Department of Dermatology, Dermatological Radiotherapy and Dermatohistopathology, Special Clinics Hornheide, Münster, Germany (Drs Schulze, Dugas-Breit); Department of Dermatology, University Hospital Jena, Jena, Germany (Drs Elsner, Gina); Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University, Erlangen-Nürnberg, Germany (Drs Drexler, Weistenhöfer); Department of Dermatology, University Allergy Center, Medical Faculty Carl Gustav Carus, TU Dresden, Germany (Drs Bauer, Bruhn); Institute of Occupational, Social and Environmental Medicine, University Medical Center, Johannes-Gutenberg University, Mainz, Germany (Dr Letzel); Department of Dermatology, Environmental Health and Health Theory, University of Osnabrück and Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany (Dr John); Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (DGUV), Institute of Ruhr-University Bochum (IPA), Bochum, Germany (Drs Fartasch, Brüning); Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany (Drs Bachmann, Diepgen); Department of Dermatology, University Medical Center, Johannes-Gutenberg University, Mainz, Germany (Dr Lang); Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Employer's Liability Insurance Association Clinics Hamburg, Hamburg, Germany (Dr Bonness); Department of Dermatology and Allergy, University Bonn, Bonn, Germany (Drs Allam, Grobe); Department of Radiation, Institute of Occupational Health and Safety of the German Social Accident Insurance (DGUV), Sankt Augustin, Germany (Westerhausen, Dr Wittlich); and Department of Dermatology, Experimental Photobiology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany (Knuschke).
Objective: The aim of this study was to investigate the role of occupational and nonoccupational ultraviolet (UV)-exposure concerning the development of basal cell carcinoma (BCC).
Methods: We undertook a population-based multicenter case-control study. Patients with first incident BCC (n = 836) were propensity score matched by age and sex to controls without skin cancer (n = 836).
Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population-based case-control study FB-181.
Br J Dermatol
February 2018
Department of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany.
Background: Squamous cell carcinoma (SCC) is one of the most frequent types of cancer constituting a significant public health burden. Prevention strategies focus on limiting ultraviolet (UV) exposure during leisure time. However, the relative impact of occupational and nonoccupational UV exposure for SCC occurrence is unclear.
View Article and Find Full Text PDFGenomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.
Nat Genet
June 2017
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Article Synopsis
- - The research identifies 389 genetic signals related to the timing of menarche (first menstrual period) in up to 370,000 women, showing how genetics influence this aspect of puberty and link it to adult diseases.
- - Findings indicate that about 7.4% of the population variation in menarche age can be explained by these genetic signals, with a notable enrichment of associated genes in neural tissues.
- - The study suggests that the timing of puberty has causal relationships with certain cancers, independently of factors like body mass index (BMI), highlighting the intricate genetic factors influencing puberty and its long-term health effects.
Replacing cystoscopy by urine markers in the follow-up of patients with low-risk non-muscle-invasive bladder cancer?-An International Bladder Cancer Network project.
Urol Oncol
October 2016
Urologie(24)/Urologie Schön Klinik Nürnberg Fürth, Fürth, Germany; Department of Urology, Friedrich-Alexander University, Erlangen, Germany. Electronic address:
Rationale: Numerous molecular urine markers for the diagnosis of bladder cancer have been developed and evaluated mostly in case-control settings through the past decades. However, despite all efforts none of them has been included into clinical decision-making and guideline recommendations until today. The aim of this retrospective longitudinal analysis was to investigate if a molecular marker might be able to replace cystoscopy as a primary examination in diagnosis and follow-up of patients with pTa grade 1-2 bladder cancer.
View Article and Find Full Text PDFCancer mortality in Itapúa--A rural province of Paraguay 2003-2012.
Cancer Epidemiol
February 2016
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum (IPA), Buerkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. Electronic address:
Background: Itapúa is a rural department in Paraguay with a population of about 500,000 and a high degree of agro-mechanization for the production of soybean and other crops. So far, only basic health care is provided. Here we analyzed the cancer mortality in this region as a first step towards epidemiological data for cancer prevention.
View Article and Find Full Text PDFRapid determination of nine parabens and seven other environmental phenols in urine samples of German children and adults.
Int J Hyg Environ Health
November 2014
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany. Electronic address:
We developed a fast, selective and sensitive on-line LC/LC-MS/MS method for the simultaneous determination of nine parabens and seven environmental phenols in urine. Parabens are widely used as antimicrobial preservatives. Bisphenol A, triclosan, triclocarban, 2-phenylphenol, and benzophenones are used inter alia in disinfectants, sunscreens and in polymers.
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