Associations of Short-Term Ozone Exposure With Hypoxia and Arterial Stiffness.

Background: Epidemiological studies reported associations between ozone (O) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O-associated diseases; therefore, we hypothesized that O exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.

Objectives: This study aimed to investigate associations of short-term O exposure with hypoxic biomarkers and arterial stiffness.

Associations between long-term exposure to fine particulate matter and its constituents with lung cancer incidence: Evidence from a prospective cohort study in Beijing, China.

Association between long-term exposure to ambient fine particulate matter (PM) and lung cancer incidence is well-documented. However, the role of different PM constituents [black carbon (BC), ammonium (NH), nitrate (NO), organic matter (OM), and inorganic sulfate (SO)] remain unclear. The study aimed to specify the associations between PM constituents and lung cancer incidence.

Morbidity, Mortality, and Epidemiological Features of Clinical Invasive Listeriosis Isolates from Sentinel Surveillance in Beijing, China, 2013-2022.

Listeriosis is a relatively rare but severe foodborne disease, which has significant public health concern of persons with underlying conditions and pregnant women. This study aimed to estimate the morbidity, mortality, and fatality rates of listeriosis over a 10-year period and clarify the epidemiological features of the pathogen in Beijing, China, based on voluntary reporting of sentinel surveillance. A total of 228 listeriosis cases were reported with annual morbidity rate of 1.

Estimating the Risk of Women Anemia Associated with Ozone Exposure Across 123 Low- and Middle-Income Countries: A Multicenter Epidemiological Study.

Anemia in women of reproductive age (WRA) presents a pressing global public health issue, particularly in low- and middle-income countries (LMICs). Yet, the potential impact of ozone (O) exposure on anemia remains uncertain. The study included 1,467,887 eligible women from 83 surveys of 45 LMICs between 2004 to 2020.

Observed Effects on Very Early Pregnancy Linked to Ambient PM Exposure in China among Women Undergoing Fertilization-Embryo Transfer.

The adverse effect of ambient PM exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort of 141,040 cycles to evaluate the effect of PM exposure on the VEP using the fertilization and embryo transfer platform and high-resolution PM data in China. We first investigated the association between PM exposure 1 week before and 1 week after the embryo transfer date and VEP.

The 2023 report of the synergetic roadmap on carbon neutrality and clean air for China: Carbon reduction, pollution mitigation, greening, and growth.

The response to climate change and air pollution control demonstrates strong synergy across scientific mechanisms, targets, strategies, and governance systems. This report, based on a monitoring indicator system for coordinated governance of air pollution and climate change, employs an interdisciplinary approach combining natural and social sciences. It establishes 20 indicators across five key areas: air pollution and climate change, governance systems and practices, structural transformation and technologies, atmospheric components and emission reduction pathways, and health impacts and co-benefits.

Effects of combined exposure to PM, O, and NO on health risks of different disease populations in the Beijing-Tianjin-Hebei region.

Air pollution adversely affects people's health. Under the current background of compound air pollution in China, the emission reduction potential of air pollution control has significantly decreased, and there are few studies on multi-pollutant emission reduction and synergistic effects. PM, O, and NO have caused the enormous disease burden and health risks.

Association between alkali and alkaline earth elements in chorionic villus and risk for spontaneous abortion.

Exposure to specific alkali and alkaline earth elements(AEs/AEEs) has been reported that are linked to an increased risk of spontaneous abortion. However, the direct evidence of exposure in the uterus are absent. Therefore, we collected chorionic villi after spontaneous abortion or induced abortion in Peking University Third Hospital.

Association of early-life factors with biological age acceleration and the mediating effect of social environment risks in middle-aged and older adults.

Background: Adverse early-life events influence the health with ageing throughout the life course. However, the effects of combined early-life risks on ageing acceleration in adults and the roles of social environment risks remain unknown.

Objective: To investigate associations of maternal smoking, breastfeeding and birth weight with accelerated biological age (BA), and to explore genetic-predicted effect and mediating effect of social environment risks.

Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China.

Background: Declining intrinsic capacity (IC) significantly impacts health outcomes in aging populations. While weak handgrip strength (HGS) is associated with IC impairment, the role of HGS asymmetry remains unclear, especially among older Chinese cohorts.

Methods: We included participants aged ≥60 years from the 2015 wave of the China Health and Retirement Longitudinal Study (CHARLS).

Maternal exposure to fine particulate matter in the air and risk for fetal congenital heart defects: a case-control study.

Prior research into the association between fine particulate matter (PM) exposure and the risk for fetal congenital heart defect (CHD) has yielded inconclusive and conflicting results. More epidemiologic evidence from different regions is necessary. A case-control study was conducted with 360 CHD cases and 3600 healthy newborns.

Association between Metal(loid) Exposure and Risk of Polycystic Ovary Syndrome Mediated by Anti-Müllerian Hormone among Women Undergoing Fertilization and Embryo Transfer.

Objective: To investigate the relationship and potential pathways between metal(loid) exposure and the risk of polycystic ovary syndrome (PCOS) in women of childbearing age.

Methods: This case-control study included 200 patients with PCOS (cases) and 896 non-PCOS controls with the age of 25-37 years. The concentrations of 29 metal(loid)s in the follicular fluid (FF) and clinical indicators in the serum were measured in all participants.

Specifying the Associations between PM Constituents and Gastrointestinal Cancer Incidence: Findings from a Prospective Cohort Study in Beijing, China.

This study aimed to test the association between PM and the incidence of gastrointestinal (GI) cancer, and further to detect the primary constituents on this association. A sum of 142,982 participants without GI cancer at baseline were derived from the National Urban Cancer Screening Program in Beijing (2013-2019). The 5 year averaged concentrations of PM mass and its five constituents, namely, black carbon (BC), ammonium (NH), nitrate (NO), organic matter (OM), and inorganic sulfate (SO), were estimated by using a hybrid machine learning model.

Establishing a Multifaceted Comprehensive Maternity Cohort Facilitates Understanding of How Environmental Exposures Impact Perinatal Health.

China's "three-child policy", implemented in response to population aging, has made the protection of maternal and infant health an urgent priority. In this environmental and medical big-data era, the Zhejiang Environmental and Birth Health Research Alliance (ZEBRA) maternity cohort was established with the aim of identifying risk factors for perinatal morbidity and mortality from the perspectives of both observational epidemiology and experimental etiology. Compared with conventional birth cohorts, the inclusion of a maternity cohort allows greater scope for research and places an emphasis on maternal health.

Development of a Method to Determine the Environmental Burden of Diseases and an Application to Identify Factors Driving Changes in the Number of PM-Related Deaths in China between 2000 and 2010.

The attributable burden is codetermined by the exposure level and nontarget characteristics. However, the conventional method of health impact assessment based on preestablished exposure-response functions includes only a few well-known characteristics and thus is insufficient to capture the comprehensive variation. We aimed to develop a method to fuse health impact assessment with epidemiological analysis and to identify factors driving baseline risk.

Regional Disparities, Economic Development, and Neonatal Mortality and Hospital Delivery in China.

Importance: A negative association between neonatal mortality and hospital delivery has been found in some low- and lower-middle-income countries but not in rural settings characterized by poor quality of maternal and child health care.

Objective: To examine the association between neonatal mortality and hospital delivery in China across urban and rural regions, regional disparities, and varying levels of economic development.

Design, Setting, And Participants: This retrospective cohort study used county-level data from 2008 to 2020 from the National Maternal & Child Health Statistics across mainland China.

Bidirectional longitudinal associations between depressive symptoms and somatic conditions after adverse childhood experiences in middle-aged and older Chinese: A causal mediation analysis.

Background: Whether adverse childhood experiences (ACEs) preferentially induce depressive symptoms or somatic conditions remains to be explored.

Methods: Data were from the China Health and Retirement Longitudinal Study (CHARLS) 2011-2018. Fourteen ACEs were retrospectively reported and divided into 0, 1, 2, 3, and 4 or more.

Periconceptional polycyclic aromatic hydrocarbon levels in maternal hair and fetal risk for congenital heart defects.

Background: Congenital heart defects (CHDs) have a complex etiology, and environmental factors play an important role in their occurrence. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous chemicals, and some have teratogenic potential. However, few studies have examined PAHs exposure and CHD risk.

Association between exposure to greenspace and ECG abnormalities in China: a nationwide longitudinal study.

Background: Greenspace is an important modifiable environmental factor that is associated with health and well-being. Although previous research has shown that exposure to greenspace is beneficial for cardiovascular diseases, studies have rarely focused on early subclinical health outcomes such as electrocardiogram (ECG) abnormality.

Methods: We developed a longitudinal study using data from the China National Stroke Screening Survey (2013-2019).

[Nutritional status and influencing factors of breast milk vitamin A among lactating women in three regions of Chin].

Objective: To evaluate the nutritional status of vitamin A (VitA) in breast milk and its influencing factors among lactating women in the Weihai, Yueyang, and Baotou of China.

Methods: From May to July 2014, 403 lactating mothers at (42±7) d postpartum were recruited from three Chinese cities, Weihai in Shandong Province, Yueyang in Hunan Province, and Baotou in Inner Mongolia. Basic information of lactating women and newborns and fish intake information of the lactating women in the last month were collected.