Influence of Pumping Regime on Temperature Resolution in Nanothermometry.

In recent years, optical nanothermometers have seen huge improvements in terms of precision as well as versatility, and several research efforts have been directed at adapting novel active materials or further optimizing the temperature sensitivity. The signal-to-noise ratio of the emission lines is commonly seen as the only limitation regarding high precision measurements. The role of re-absorption caused by a population of lower energy levels, however, has so far been neglected as a potential bottleneck for both high resolution and material selection.

3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation.

3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples.

X-ray dark-field tomography reveals tooth cracks.

Cracked tooth syndrome (CTS) is a common clinical finding for teeth, it affects about 5% of all adults each year. The finding of CTS is favored by several risk factors such as restorations, bruxism, occlusion habits, and age. Treatment options range, depending on the severity, from no treatment at all to tooth extraction.

Relativistic Bell Test within Quantum Reference Frames.

A still widely debated question in the field of relativistic quantum information is whether entanglement and the degree of violation of Bell's inequalities for massive relativistic particles are frame independent or not. At the core of this question is the effect that spin gets entangled with the momentum degree of freedom at relativistic velocities. Here, we show that Bell's inequalities for a pair of particles can be maximally violated in a special-relativistic regime, even without any postselection of the momentum of the particles.

Evaluation of laser induced sarcomere micro-damage: Role of damage extent and location in cardiomyocytes.

Whereas it is evident that a well aligned and regular sarcomeric structure in cardiomyocytes is vital for heart function, considerably less is known about the contribution of individual elements to the mechanics of the entire cell. For instance, it is unclear whether altered Z-disc elements are the reason or the outcome of related cardiomyopathies. Therefore, it is crucial to gain more insight into this cellular organization.

Crossover from two-frequency pulse compounds to escaping solitons.

The nonlinear interaction of copropagating optical solitons enables a large variety of intriguing bound-states of light. We here investigate the interaction dynamics of two initially superimposed fundamental solitons at distinctly different frequencies. Both pulses are located in distinct domains of anomalous dispersion, separated by an interjacent domain of normal dispersion, so that group velocity matching can be achieved despite a vast frequency gap.

Molecular Origin of Blood-Based Infrared Spectroscopic Fingerprints*.

Infrared spectroscopy of liquid biopsies is a time- and cost-effective approach that may advance biomedical diagnostics. However, the molecular nature of disease-related changes of infrared molecular fingerprints (IMFs) remains poorly understood, impeding the method's applicability. Here we probe 148 human blood sera and reveal the origin of the variations in their IMFs.

Erratum: Arshad, N., et al. Super Hydrophilic Activated Carbon Decorated Nanopolymer Foam for Scalable, Energy Efficient Photothermal Steam Generation, as an Effective Desalination System. 2020, , 2510.

The authors wish to make the following corrections to this paper [...

Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring.

Health state transitions are reflected in characteristic changes in the molecular composition of biofluids. Detecting these changes in parallel, across a broad spectrum of molecular species, could contribute to the detection of abnormal physiologies. Fingerprinting of biofluids by infrared vibrational spectroscopy offers that capacity.

Diffusion Biased by a Soft Neck Linker Regulates Kinesin Stepping.

Conventional kinesin is a high-performance motor that moves primarily toward the plus end of microtubules and occasionally toward the opposite direction. The physical mechanism of this directional stepping remains unclear. Here we develop a kinetic two-cycle model incorporating kinesin forward and backward stepping, in which the neck linker zippering and ATP catalysis process are conserved in backward steps.

High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling.

To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC-specific hurdles toward their mass production. Perfused suspension culture (3D) of matrix-free hPSC aggregates in STBRs was applied to identify and control process-limiting parameters including pH, dissolved oxygen, glucose and lactate levels, and the obviation of osmolality peaks provoked by high density culture. Media supplements promoted single cell-based process inoculation and hydrodynamic aggregate size control.

Ultracold atom interferometry in space.

Bose-Einstein condensates (BECs) in free fall constitute a promising source for space-borne interferometry. Indeed, BECs enjoy a slowly expanding wave function, display a large spatial coherence and can be engineered and probed by optical techniques. Here we explore matter-wave fringes of multiple spinor components of a BEC released in free fall employing light-pulses to drive Bragg processes and induce phase imprinting on a sounding rocket.

Development of Human iPSC-Derived Functional Neuronal Networks on Laser-Fabricated 3D Scaffolds.

Neural progenitor cells generated from human induced pluripotent stem cells (hiPSCs) are the forefront of ″brain-on-chip″ investigations. Viable and functional hiPSC-derived neuronal networks are shaping powerful models for evaluating the normal and abnormal formation of cortical circuits, understanding the underlying disease mechanisms, and investigating the response to drugs. They therefore represent a desirable instrument for both the scientific community and the pharmacological industry.

Shortcuts to Adiabaticity for the Quantum Rabi Model: Efficient Generation of Giant Entangled Cat States via Parametric Amplification.

We propose a method for the fast generation of nonclassical ground states of the Rabi model in the ultrastrong and deep-strong coupling regimes via the shortcuts-to-adiabatic (STA) dynamics. The time-dependent quantum Rabi model is simulated by applying parametric amplification to the Jaynes-Cummings model. Using experimentally feasible parametric drive, this STA protocol can generate large-size Schrödinger cat states, through a process that is ∼10 times faster compared to adiabatic protocols.

Measuring the α-particle charge radius with muonic helium-4 ions.

The energy levels of hydrogen-like atomic systems can be calculated with great precision. Starting from their quantum mechanical solution, they have been refined over the years to include the electron spin, the relativistic and quantum field effects, and tiny energy shifts related to the complex structure of the nucleus. These energy shifts caused by the nuclear structure are vastly magnified in hydrogen-like systems formed by a negative muon and a nucleus, so spectroscopy of these muonic ions can be used to investigate the nuclear structure with high precision.

Green thin film for stable electrical switching in a low-cost washable memory device: proof of concept.

Low-cost and washable resistive switching (RS) memory devices with stable retention and low operational voltage are important for higher speed and denser non-volatile memories. In the case of green electronics, pectin has emerged as a suitable alternative to toxic metal oxides for resistive switching applications. Herein, a pectin-based thin film was fabricated on a fluorine-doped tin oxide glass substrate for RS mechanism.

Stable coherent mode-locking based on [Formula: see text] pulse formation in single-section lasers.

Here we consider coherent mode-locking (CML) regimes in single-section cavity lasers, taking place for pulse durations less than atomic population and phase relaxation times, which arise due to coherent Rabi oscillations of the atomic inversion. Typically, CML is introduced for lasers with two sections, the gain and absorber ones. Here we show that, for certain combination of the cavity length and relaxation parameters, a very stable CML in a laser, containing only gain section, may arise.

Culture surface protein coatings affect the barrier properties and calcium signalling of hESC-RPE.

Human pluripotent stem cell-derived retinal pigment epithelium (RPE) transplantation is currently under evaluation as treatment for macular degeneration. For therapeutic applications, cryostorage during cell production is typically needed with potential consequences to cell functionality. We have previously shown that the culture substrate affects human embryonic stem cell-derived RPE (hESC-RPE) properties in fresh cultures.

Nanoenabled Photothermal Materials for Clean Water Production.

Solar-powered water evaporation is a primitive technology but interest has revived in the last five years due to the use of nanoenabled photothermal absorbers. The cutting-edge nanoenabled photothermal materials can exploit a full spectrum of solar radiation with exceptionally high photothermal conversion efficiency. Additionally, photothermal design through heat management and the hierarchy of smooth water-flow channels have evolved in parallel.

Vascular Network Formation on Macroporous Polydioxanone Scaffolds.

In this study, microvascular network structures for tissue engineering were generated on newly developed macroporous polydioxanone (PDO) scaffolds. PDO represents a polymer biodegradable within months and offers optimal material properties such as elasticity and nontoxic degradation products. PDO scaffolds prepared by porogen leaching and cryo-dried to achieve pore sizes of 326 ± 149.

Super Hydrophilic Activated Carbon Decorated Nanopolymer Foam for Scalable, Energy Efficient Photothermal Steam Generation, as an Effective Desalination System.

Clean water scarcity is still an intense, prolonged global issue that needs to be resolved urgently. The solar steam generation has shown great potential with a high energy conversion efficiency for clean water production from seawater and wastewater. However, the high evaporation rate of water cannot be preserved due to the inevitable fouling of solar absorbers.

Probing Ligand-Receptor Interaction in Living Cells Using Force Measurements With Optical Tweezers.

This work probes the binding kinetics of COOH-terminus of (c-CPE) and claudin expressing MCF-7 cells using force spectroscopy with optical tweezers. c-CPE is of high biomedical interest due to its ability to specifically bind to claudin with high affinity as well as reversibly disrupt tight junctions whilst maintaining cell viability. We observed single-step rupture events between silica particles functionalized with c-CPE and MCF-7 cells.