Cytoprotective Effects of Dinitrosyl Iron Complexes on Viability of Human Fibroblasts and Cardiomyocytes.

Nitric oxide (NO) is an important signaling molecule that plays a key role in maintaining vascular homeostasis. Dinitrosyl iron complexes (DNICs) generating NO are widely used to treat cardiovascular diseases. However, the involvement of DNICs in the metabolic processes of the cell, their protective properties in doxorubicin-induced toxicity remain to be clarified.

Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro.

The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes cytochrome c oxidase and monoamine oxidase A was studied.

Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets.

It was shown for the first time that pentaamino acid derivative of fullerene C (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

Traveling-waves of metal-containing monomer polymerization without diffusion and heat-transfer.

The new approach for modeling kinetics of complex spatial self-propagating traveling-wave reactions is proposed. This approach is intended to replace well-known reaction-diffusion equations and self-propagating high-temperature synthesis (SHS) as methods for mathematical modeling of spatial propagation of chemical reactions. A chemical kinetic model for frontal polymerization of metal-containing monomers under this approach is suggested.

Purely Spectroscopic Determination of the Spin Hamiltonian Parameters in High-Spin Six-Coordinated Cobalt(II) Complexes with Large Zero-Field Splitting.

Accurate determination of the spin Hamiltonian parameters in transition-metal complexes with large zero-field splitting (ZFS) is an actual challenge in studying magnetic and spectroscopic properties of high-spin transition metal complexes. Recent critical papers have convincingly shown that previous determinations of these parameters, based only on the magnetic data, have low accuracy and reliability. A combination of X-band electron paramagnetic resonance (EPR) spectroscopy and SQUID magnetometry seems to be a more convincing and accurate approach.

Double-Decker Paramagnetic {(K)(H Hhp) } Radical Dianions Comprising Two [30]Trithia-2,3,5,10,12,13,15,20,22,23,25,30-Dodecaazahexaphyrins and a Potassium Ion.

Reduction of free-base [30]trithia-2,3,5,10,12,13,15,20,22,23,25,30-dodecaazahexaphyrin (H Hhp) yields {cryptand[2.2.2](K)} {(K)(H Hhp) }⋅4C H Cl (1) containing double-decker {(K)(H Hhp) } radical dianions, whose structure was elucidated using X-ray diffraction.

Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation.

We synthesized conjugates of tacrine with 1,2,4-thiadiazole derivatives linked by two different spacers, pentylaminopropene (compounds 4) and pentylaminopropane (compounds 5), as potential drugs for the treatment of Alzheimer's disease (AD). The conjugates effectively inhibited cholinesterases with a predominant effect on butyrylcholinesterase (BChE). They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced β-amyloid aggregation.

Electrochemical Properties of Carbon Aerogel Electrodes: Dependence on Synthesis Temperature.

A series of carbon aerogels (C-AGs) were prepared by the pyrolysis of resorcinol-formaldehyde aerogels at 700-1100 °C as potential supercapacitor electrodes, and their texture and electrochemical properties were determined. The specific surface area of all C-AGs was in the range of 700-760 m/g, their electron conductivity increased linearly from 0.4 to 4.

Recent advances in metallopolymer-based drug delivery systems.

Metallopolymers (MPs) or metal-containing polymers have shown great potential as new drug delivery systems (DDSs) due to their unique properties, including universal architectures, composition, properties and surface chemistry. Over the past few decades, the exponential growth of many new classes of MPs that deal with these issues has been demonstrated. This review presents and assesses the recent advances and challenges associated with using MPs as DDSs.

Flow Structure and Mixing Efficiency of Viscous Fluids in Microchannel with a Striped Superhydrophobic Wall.

The peculiarities of a Newtonian fluid flow structure in microchannels with a striped superhydrophobic lower wall texture are studied by means of numerical modeling. In the Cassie-Baxter state, an oblique orientation of such a texture induces helicoidal streamlines with micro spirals. Such a flow structure favors the enhancement of fluid mixing efficiency, which can be quantified using the total root-mean-square deviation of streamlines from the microchannel axis.

Polymer Electrolytes for LIBs Based on Perfluorinated Sulfocationic Nepem-117 Membrane and Aprotic Solvents.

Polymer electrolytes have been obtained by using Nepem-117 membranes in a Li form intercalated by polar aprotic solvents, such as dimethylformamide, dimethyl sulfoxide (DMSO), and dimethylacetamide (DMA), and solvent mixtures, such as ethylene carbonate-propylene carbonate (EC-PC), EC-DMA, EC-PC-DMA, and EC-PC-DMA-tetrahydrofuran. The obtained electrolytes have been characterized by IR impedance and Li pulsed field gradient NMR spectroscopy. Ion mobility was observed to increase with higher degrees of solvation of the membranes.

Influence of hemoglobin and albumin on the NO donation effect of tetranitrosyl iron complex with thiosulfate.

The effects of deoxyhemoglobin (Hb) and albumin on the NO-donor activity of the anionic tetranitrosyl iron complex with thiosulfate ligands (1) were studied for the first time. It was shown that Hb significantly stabilizes complex 1; in its presence, NO generation from the complex proceeds at a noticeably slower rate. A similar effect is observed when complex 1 is bound to albumin, in which case complex 1 decomposes 27 times slower than in the absence of albumin in the solution.

Membranotropic and Antiradical Properties of 2-Nitroxysuccinate 3-Hydroxy-6-Methyl-2-Ethylpyridine.

We studied membranotropic properties of NO donor 2-nitroxysuccinate 3-hydroxy-6-methyl-2-ethylpyridine and its structural analog succinate 3-hydroxy-6-methyl-2-ethylpyridine (Mexidol). It was shown that the compounds under study are incorporated into modeled membranes and form long-living complexes with pyrene in the region of fatty acid tails of phospholipids. Luminol-amplified chemiluminescence analysis showed that both compounds exhibited antiradical activity and in a concentration of 0.

Weakly bound molecules as sensors of new gravitylike forces.

Several extensions to the Standard Model of particle physics, including light dark matter candidates and unification theories predict deviations from Newton's law of gravitation. For macroscopic distances, the inverse-square law of gravitation is well confirmed by astrophysical observations and laboratory experiments. At micrometer and shorter length scales, however, even the state-of-the-art constraints on deviations from gravitational interaction, whether provided by neutron scattering or precise measurements of forces between macroscopic bodies, are currently many orders of magnitude larger than gravity itself.

Biomimetic Approach to Inhibition of Photooxidation in Organic Solar Cells Using Beta-Carotene as an Additive.

Recent efficiency records of organic photovoltaics (OPV) highlight stability as a limiting weakness. Incorporation of stabilizers is a desirable approach for inhibiting degradation-it is inexpensive and readily up-scalable. However, to date, such additives have had limited success.

Synthesis and Characterization of 3-(5-(Fluorodinitromethyl)-1H-1,2,4-triazol-3-yl)-4-nitrofurazan: A Novel Promising Energetic Component of Boron-based Fuels for Rocket Ramjet Engines.

The synthesis of a new energetic 1,2,4-triazole compound bearing nitrofurazanyl and fluorodinitromethyl units, which may find use as a component for rocket ramjet engines (RRE), is described. The target product was prepared in a four-step process applying oxidation/nitration/decarboxylation/fluorination reactions and is fully characterized. Its density and structural features were uniquely determined by X-ray analysis.

Spin-orbit vibronic coupling in Π4 states of linear triatomic molecules.

The Renner vibronic-coupling problem in Π electronic states of linear molecules is analyzed with rigorous and systematic inclusion of spin-orbit (SO) coupling. The 8 × 8 Hamiltonian matrix of a Π state in the diabatic electronic representation has been constructed by a Taylor expansion in the bending normal mode up to second order. As previously found for Π states and Π states, SO-induced vibronic-coupling terms that are linear in the bending amplitude exist in addition to the quadratic electrostatic Renner coupling.

Molecular Structure and Magnetic and Optical Properties of Endometallonitridofullerene Sc N@I -C in Neutral, Radical Anion, and Dimeric Anionic Forms.

A series of compounds with Sc N@I -C in the neutral, monomeric, and dimeric anion states have been prepared in the crystalline form and their molecular structures and optical and magnetic properties have been studied. The neutral Sc N@I -C ⋅3 C H Cl (1) and (Sc N@I -C ) (TPC) ⋅5 C H Cl (2, TPC=triptycene) compounds both crystallized in a high-symmetry trigonal structure. The reduction of Sc N@I -C to the radical anion resulted in dimerization to form diamagnetic singly bonded (Sc N@I -C ) dimers.

{CpFe(CO)Sn(Macrocycle)} Radicals with Intrinsic Charge Transfer from CpFe(CO) to Macrocycles (Cp: Cp or Cp*); Effective Magnetic Coupling between Radical Trianionic Macrocycles.

Neutral {CpFe(CO)[Sn(Pc)]} {Cp is cyclopentadienyl (, ) or Cp* is pentamethylcyclopentadienyl (); Pc: phthalocyanine}, {Cp*Fe(CO)[Sn(Nc)]} (, Nc: naphthalocyanine), and {CpFe(CO)[Sn(TPP)]} (, TPP: tetraphenylporphyrin) complexes in which CpFe(CO) fragments (Cp: Cp or Cp*) are coordinated to Sn(macrocycle) have been obtained. The product complexes were obtained at the reaction of charge transfer from CpFe(CO) (Cp: Cp or Cp*) to [Sn(macrocycle)] to form the diamagnetic Fe and paramagnetic radical trianionic macrocycles. As a result, these formally neutral complexes contain = 1/2 spins delocalized over the macrocycles.

Synthesis of Novel 2-(Het)arylpyrrolidine Derivatives and Evaluation of Their Anticancer and Anti-Biofilm Activity.

A library of novel 2-(het)arylpyrrolidine-1-carboxamides were obtained via a modular approach based on the intramolecular cyclization/Mannich-type reaction of -(4,4-diethoxybutyl)ureas. Their anti-cancer activities both in vitro and in vivo were tested. The in vitro activity of some compounds towards M-Hela tumor cell lines was twice that of the reference drug tamoxifen, whereas cytotoxicity towards normal Chang liver cell did not exceed the tamoxifen toxicity.

Sandwich double-decker Er(iii) and Yb(iii) complexes containing naphthalocyanine moiety: synthesis and investigation of the effect of a paramagnetic metal center.

Novel heteroleptic Er(iii) and Yb(iii) naphthalocyaninato-phthalocyaninates containing an octa-phenyl or octa-phenoxysubstituted naphthalocyanine deck were synthesised and identified by H NMR, EPR and high resolution MALDI-TOF/TOF mass spectrometry. Direct synthesis of novel homoleptic Yb(iii) bis (octa-phenylnaphthalocyaninate) was carried out. Downfield lanthanide induced shifts of the aromatic protons in target compounds were observed compared with the corresponding diamagnetic Lu(iii) complexes.

Noncontact tip-enhanced Raman spectroscopy for nanomaterials and biomedical applications.

Tip-enhanced Raman spectroscopy (TERS) has been established as one the most efficient analytical techniques for probing vibrational states with nanoscale resolution. While TERS may be a source of unique information about chemical structure and interactions, it has a limited use for materials with rough or sticky surfaces. Development of the TERS approach utilizing a non-contact scanning probe microscopy mode can significantly extend the number of applications.

Evolution of Oxygen-Ion and Proton Conductivity in Ca-Doped LnZrO (Ln = Sm, Gd), Located Near Pyrochlore-Fluorite Phase Boundary.

SmCaZrO (x = 0, 0.05, 0.1) and GdCaZrO (x = 0.

Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells.

The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma cells, i.e.

Slow Magnetic Relaxation, Antiferromagnetic Ordering, and Metamagnetism in Mn (H dapsc)-Fe (CN) Chain Complex with Highly Anisotropic Fe-CN-Mn Spin Coupling.

Reactions of [Mn(H dapsc)Cl ]⋅H O (dapsc=2,6- diacetylpyridine bis(semicarbazone)) with K [Fe(CN) ] and (PPh ) [Fe(CN) ] lead to the formation of the chain polymeric complex {[Mn(H dapsc)][Fe(CN) ][K(H O) ]} ⋅1.5n H O (1) and the discrete pentanuclear complex {[Mn(H dapsc)] [Fe(CN) ] (H O) }⋅4 CH OH⋅3.4 H O (2), respectively.