Endocrine alterations in patients with pachydermoperiostosis.

Context: Pachydermoperiostosis (primary hypertrophic osteoarthropathy, PHO) usually due to biallelic loss-of-function variants in HPGD and SLCO2A1, has some features overlapping with acromegaly and often referred to endocrinologists. A detailed endocrine assessment is not available for these patients.

Objective: To assess the genetic and endocrine characteristics of PHO patients referred to endocrine centres with a possible diagnosis of acromegaly.

Relationship Between Subjectively Assessed Physical Activity (GPAQ) and Quality of Life (WHOQOL-BREF) of Aging Employees in JIPMER, Puducherry: A Cross-Sectional Analytical Study.

Background: Physical activity appears to be one of the most important strategies for preventing physical and mental disorders. Regular physical activity (PA) may prolong life and appears to be a preventative measure against genetic and molecular aging.

Aim: To find the relationship between aging adults' quality of life (QOL) and PA.

Implicit bias assessment by career stage in medical education training: a narrative review.

Implicit biases involve associations outside conscious awareness that lead to a negative evaluation of a person based on individual characteristics. Early evaluation of implicit bias in medical training can prevent long-term adverse health outcomes related to racial bias. However, to our knowledge, no present studies examine the sequential assessment of implicit bias through the different stages of medical training.

Unusual Coats-like response in occlusive retinal periphlebitis.

Coats-like response refers to a condition where abnormal telangiectatic retinal vessels and aneurysms associated with subretinal exudation are seen in the setting of other ocular or systemic diseases. So far, it has been described with various ocular disorders like retinitis pigmentosa, chronic ischemic branch retinal vein obstruction and pars planitis. A man in his 30s presented with a 1-month history of diminution of vision in the left eye.

Viral Infection Associated Membranous Nephropathy: Clinical Presentation and Outcomes.

Background: Viral infections can increase the likelihood of an individual developing membranous nephropathy (MN). Limited information is available regarding the treatment approaches for such cases. We conducted a review focusing on hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV)-associated MN.

Physiological, Psychological, and Functional Health Determinants of Depressive Symptoms Among the Elderly in India: Evaluation of Classification Performance of XGBoost Models.

Background: Depression among the elderly is a growing public health concern, especially in India. This study aimed to investigate the predictive validity of physiological, psychological, and functional health factors in classifying the level of depressive symptoms among the elderly using the extreme gradient boosting (XGBoost) technique. Additionally, we compared the performance of models trained on original and resampled data.

Identification of Novel MICB Alleles in Haematopoietic Stem Cell Donors of Indian Origin.

Novel MICB alleles MICB*004:01:31, MICB*004:01:32, MICB*004:01:33 and MICB*005:02:59, were identified using next generation sequencing.

Assessment and management for latent tuberculosis before advanced therapies for immune-mediated inflammatory diseases: A comprehensive review.

Tuberculosis (TB), caused by Mycobacterium TB, is the most significant infectious cause of mortality across the globe. While TB disease can prey on immunocompetent individuals, it is more likely to occur in immunocompromised individuals. Immune-mediated inflammatory diseases (IMIDs) are a group of diseases (rheumatoid arthritis, inflammatory bowel disease, ankylosing spondylitis, psoriasis, hidradenitis suppurative, autoimmune blistering diseases, and others) where there may be a need for systemic immunosuppression to control the disease manifestations, treat symptoms and improve long term outcomes.

Lerodalcibep and evolocumab for the treatment of homozygous familial hypercholesterolaemia with PCSK9 inhibition (LIBerate-HoFH): a phase 3, randomised, open-label, crossover, non-inferiority trial.

Background: Lerodalcibep, a small binding anti-PCSK9 protein (adnectin), showed effective LDL cholesterol reduction in heterozygous familial hypercholesterolaemia. We aimed to assess the safety and efficacy of lerodalcibep and evolocumab in a globally diverse homozygous familial hypercholesterolaemia population.

Methods: This phase 3, randomised, open-label, crossover, non-inferiority study consisted of two 24-week treatment periods separated by an 8-week washout.

Abbreviated Duration of Vasoactive Agents Has Similar Outcomes as Standard Duration of Therapy in Patients with Liver Cirrhosis and Variceal Bleeding: An Individual Patient Data Meta-Analysis.

Background: This two-stage individual patient data meta-analysis (IPD-MA) compared the efficacy of a shorter duration (≤ 2 days) of vasoactive (VA) drug therapy to standard duration (3-5 days) after acute variceal bleeding (AVB) in patients with liver cirrhosis.

Patients And Methods: Randomized clinical trials on patients with cirrhosis and AVB undergoing endoscopic band ligation which compared a short duration versus the standard duration of VA therapy were included. The primary outcome was 5-day rebleeding rate.

The Intermittent Pneumatic Compression Influences Edema Fluid Movement and Promotes the Compensatory Drainage Pathways in Patients with Breast Cancer Related Lymphedema.

Upper limb lymphedema is the most common complication after breast cancer therapy. Suddenly disturbed lymphatic transport in the affected arm causes tissue fluid accumulation in tissue spaces, limb enlargement, and secondary changes in tissue. Early compression therapy is necessary.

Depression, anxiety, stress, and coping among men with infertility seeking treatment at a tertiary care hospital in South India: A mixed-method study.

Background: Many studies in India and all over the world have focused on the psychological aspect of infertility in women, but only a few have explored it among men. To deal with psychological distress, sometimes, individuals may use maladaptive coping strategies which can further worsen the stress instead of reducing it.

Aim: To assess symptoms of depression, anxiety, stress, and various coping strategies adopted by men with infertility along with exploring their coping experiences.

Unveiling the landscape of antistigma interventions for individuals with substance use disorders: A scoping review.

Background: Stigma against persons living with substance use disorders (PLSUD) fosters social and health inequities.

Aim: We aimed to map different populations targeted by antistigma interventions, analyze specific characteristics of these interventions, and identify and categorize the theoretical frameworks used in these interventions.

Methods: We examined randomized controlled trials and quasi or pre-experimental studies targeting stigma against PLSUD.

Knowledge and Awareness of Medication-Related Osteonecrosis of the Jaw Among Dental Practitioners in Mumbai: A Questionnaire-Based Survey.

Introduction: Osteonecrosis of the jaw resulting from the adverse effects of medical treatments is known as medication-related osteonecrosis of the jaws (MRONJ). The knowledge of dental professionals about this condition is crucial in addressing it on a regional and global scale. This study aims to assess the knowledge and awareness of MRONJ among dental practitioners in Mumbai.

Ukrainian Patients' Perspectives on Advanced Pharmaceutical Services Provided by Polish Pharmacists: A Cross-Border Support Initiative.

Introduction: Pharmacists are essential healthcare professionals which play a pivotal role in public health protection by offering diverse pharmacy services. This includes not only serving individuals in Ukraine but also addressing the needs of Ukrainian citizens residing in Poland. An exemplary initiative is the creation of the website , which provides organized and systematic support.

Enhancing paediatric and congenital cardiology e-learning postgraduate education: insights from the Association for European Paediatric and Congenital Cardiology directed webinar series.

Objective: A series of webinars covering widespread knowledge on paediatric cardiology and cardiac surgery topics was initiated by Association for European Paediatric and Congenital Cardiology, serving towards preparation for the Association for European Paediatric and Congenital Cardiology certification in paediatric and congenital cardiology. This study investigated the impact of webinars as educational tools for junior paediatric cardiologists in the post-COVID-19 pandemic era.

Materials And Methods: A cross-sectional survey design study using an online survey as a tool for the assessment of trainees.

Influence of HLA-B Leader (-21M/T) Dimorphism With Bw4/Bw6 Epitopes on Graft Versus Host Disease After Allogenic Haematopoietic Stem Cell Transplantation in North Indians.

High degree of variability in human leukocyte antigens (HLAs) system restricts availability of histocompatible HLA-matched-related donors, thus increasing reliance on worldwide bone marrow registries network. Nevertheless, due to limited coverage/accessibility/affordability of some ethnicities in these registries, haploidentical haematopoietic stem cell transplantation (HSCT) emerged as an alternative option, though with allorecognition-mediated graft versus host disease (GvHD) (>40% cases). A dimorphism [-21 methionine (M) or threonine (T)] in HLA-B leader peptide (exon 1) which differentially influences its HLA-E binding, plausibly regulates natural killer cell functionality, affecting GvHD vulnerability and clinically in practice for donor selection.

Right Ventricular Outflow Tract Obstruction: Transcatheter Correction In Tetralogy Of Fallot: A Pilot Study.

This study evaluated transcatheter approach for relieving right ventricular outflow tract (RVOT) obstruction using combined non-compliant balloon dilatation of the RVOT and conal artery occlusion in patients with Tetralogy of Fallot (TOF), both uncorrected and post-intra-cardiac repair (ICR) restenosis. A prospective study was conducted from January 2022 to June 2023, including 40 symptomatic patients aged over 12 years with RVOT obstruction in TOF. Exclusion criteria included moderate to severe pulmonary regurgitation.