A Mixed Reality-based Tele-Supervised Ultrasound Education Platform on 5G network compared to Direct Supervision: Prospective Randomized Pilot Trial.

Background: Ultrasound education is transitioning from in-person training to remote methods using mixed reality (MR) and 5G networks. Previous studies are mainly experimental, lacking randomized controlled trials in direct training scenarios.

Objective: This study aimed to compare an MR-based tele-supervised ultrasound education platform on private 5G networks with traditional in-person training for novice doctors.

A Mouse Model of Ovalbumin-Induced Airway Allergy Exhibits Altered Localization of SARS-CoV-2-Susceptible Cells in the Lungs, Which Reflects Omicron BA.5 Infection Dynamics, Viral Mutations, and Immunopathology.

Asthma, an allergic disease of the airways, is a risk factor for severity of common respiratory viral infections; however, the relationship between asthma and severity in COVID-19 remains unclear. Here, we examined the effects of SARS-CoV-2 (Omicron BA.5 strain) infection in a mouse model of airway allergy.

Psychological problems and burnout among healthcare workers: Impact of non-pharmacological lifestyle interventions.

Objective: To evaluate role of rajyoga meditation (RYM) versus stress management counselling (SMC) in addressing burnout syndrome and resultant improvement in electrocardiogram (ECG) so as to automate burnout prediction from raw ECG data with machine learning (ML).

Methods: Healthcare providers were assigned to two groups: RYM (n = 100) or SMC (n = 102). Subjects in RYM received rajyoga for 3 months including one week offline and thereafter, virtual mode.

Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice.

Background: Inhibition of sperm maturation in the epididymis is a promising post-testicular strategy for short-acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice. However, it is unknown if inhibition of ROS1 suppresses male fertility reversibly.

Wernicke's Encephalopathy (WE) Associated with Hyperemesis Gravidarum (HG) Presenting with Psychiatric Morbidity: Description of Two Cases.

Background: Hyperemesis gravidarum (HG) refers to intractable vomiting during pregnancy and is rarely associated with Wernicke's encephalopathy (WE). HG-associated WE can lead to mortality and permanent cognitive impairment if left untreated. In this report, we present two cases of WE following HG occurring in the context of comorbid severe depression.

Decoding the evidence: A synopsis of indications and evidence for catheter ablation in atrial fibrillation (Review).

The present study reviews the role of catheter ablation (CA) in the management of atrial fibrillation (AF), a widespread arrhythmia associated with increased morbidity and mortality. The present review explores current indications and recent evidence supporting CA, assessing patient outcomes and identifying common complications associated with the procedure. Emphasis is placed on optimizing risk factors prior to ablation, including weight control and hypertension management, as these measures can significantly enhance post-procedural outcomes.

Preparing radiology residents for breast MRI: A dual-site, resident-as-teacher feasibility project.

Purpose: To assess the impact of a faculty-mentored, resident-as-teacher theoretical-practical breast MRI (B-MRI) course on the reporting completeness and accuracy of "trainee" radiology residents (RRs) with basic or no experience in conventional breast imaging (CBI) and the personal skills and critical thinking of experienced, "teacher" RRs.

Methods: Six teacher-RRs from the Udine University residency program (URP) preliminarily selected and reported 55 B-MRI cases under faculty supervision. Twelve trainee-RRs (six from Udine URP and six from Vienna URP, with basic and no experience in CBI, respectively) underwent seven days of self-study on selected material, followed by a pre-training reporting test (pre-TRT) on 15 of the 55 B-MRI cases.

Carbon dot-graphene oxide-based luminescent nanosensor for creatinine detection in human urine.

A fluorescence (FL)-based nanosensor has been devised for creatinine (CR) detection in human urine specimens. The proposed nanosensor utilized a nanocomposite (NC) of carbon dots (CDs) and graphene oxide (GO). The formation of CDs/GO NC reduced the CD FL emission (λ = 390 nm, λ = 461 nm) by ~ 75%.

In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA-inhibitor varespladib.

Bungarus (krait) envenomings are well-known for their life-threatening neurotoxic effects. However, their impact on coagulation remains largely unexplored experimentally or clinically. This study, examined the effect of begins to examine venoms from four Bungarus species-B.

Polmacoxib 2mg in patients with mild to moderate idiopathic osteoarthritis of hip/knee-a randomized, double-anonymous study.

Aim: Polmacoxib, a new COX-2 inhibitor with carbonic anhydrase (CA) inhibitory action, is expected to help minimize the adverse effects associated with other NSAIDs, like GI (gastrointestinal) and CV (cardiovascular) system- related issues. The comparative efficacy and safety of polmacoxib 2 mg (manufactured by Hetero Labs Limited) versus celecoxib 200 mg (manufactured by Hetero Labs Limited) were assessed in this randomized, double-anonymous, clinical study in Indian adult patients diagnosed with idiopathic osteoarthritis (OA) of the.

Patients & Methodology: 18 years and older patients of either sex, clinically and radiographically diagnosed idiopathic knee or hip OA were randomized to receive either polmacoxib or celecoxib in a 1:1 ratio.

The impact of core curriculum revisions on Japanese medical schools: Navigating curriculum evolution.

Purpose: This study examines the impact of the 2010 and 2016 Model Core Curriculum (MCC) revisions on medical education across all 82 medical schools in Japan.

Methods: A cross-sectional survey was conducted in 2021, focusing on the response to the MCC revisions, curriculum changes, and factors influencing these changes. The survey included questions on approaches to implementing the MCC revisions, timing of curriculum updates, factors triggering these revisions, changes in student performance and career paths, and the introduction of new subjects.

Humanistic and Holistic Strategies for Combating Mental Health Sequelae in the Elderly During the Post-COVID Era.

Background: The elderly population is rapidly growing worldwide. By the year 2050, the elderly population will increase up to 2.1 billion.

Awareness of Diabetic Retinopathy Among Patients With Diabetes Mellitus in the Ernakulam District, South India: A Hospital-Based Cross-Sectional Study.

Introduction India is currently experiencing a significant burden of diabetes mellitus, characterized by its high prevalence and associated complications. Diabetic retinopathy (DR) is a major microvascular complication of diabetes, leading to blindness. Awareness regarding this ocular complication of diabetes can help prevent vision loss due to early screening and diagnosis.