15,486 results match your criteria: "Institute of Post Graduate Medical Education & Research IPGME&R and SSKMH[Affiliation]"

Introduction The COVID-19 pandemic resulted in the suspension of formative Objective Structured Clinical Examinations (OSCEs) at numerous institutions. This resulted in a significant gap in OSCE exposure for junior medical students, including those at our university. Drawing upon our prior experiences with OSCEs, we created a program to evaluate the effectiveness of near-peer teaching (NPT) in preparing third-year medical students to experience and succeed in OSCEs.

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  • The histaminergic system is crucial for learning, memory, wakefulness, and energy regulation, and its H receptors can inhibit neurotransmitter release.
  • Inverse agonists/antagonists of H receptors can enhance cognitive functions, leading to improvements in memory consolidation and retrieval.
  • The study shows that drugs thioperamide and pitolisant alter spontaneous cortical activity, promoting better communication between cortical regions, which suggests their potential for improving cognitive functions.
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  • Post Kala-azar Dermal Leishmaniasis (PKDL) emerges as a complication of visceral leishmaniasis (VL), posing challenges for disease management and ongoing elimination efforts due to its potential for ongoing transmission.
  • In this study, researchers assessed neutrophils in PKDL patients' skin biopsies, finding increased numbers of activated neutrophils and elevated levels of inflammatory markers compared to healthy controls.
  • The findings suggest that activated neutrophils may significantly influence the inflammatory environment in PKDL, highlighting the need for further understanding of their role in the disease's progression and treatment.
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Background: In 2020, a mandatory, nationwide 1-day bronchoscopy simulation-based training (SBT) course was implemented for novice pulmonology residents in the Netherlands. This pretest-posttest study was the first to evaluate the effectiveness of such a nationwide course in improving residents' simulated basic bronchoscopy skills.

Methods: After passing a theoretical test, residents followed a 1-day SBT course, available in 7 centers, where they practiced their bronchoscopy skills step-by-step on a virtual reality simulator under pulmonologist supervision.

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The Thematic Analysis of Barriers to Immediate Post-Partum Long-Acting Reversible Contraception.

Healthcare (Basel)

November 2024

Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 23819, Jeddah 21442, Saudi Arabia.

Background: Globally, many women express the desire to avoid immediate pregnancy for 24 months postdelivery, and only forty percent use contraceptives during this period. There is an enormous demand for postpartum family planning, particularly in developing countries with low- or middle-income grades. Postpartum intrauterine devices such as long-acting reversible contraceptives (LARCs) are among the most effective methods of family planning in the immediate postpartum period, yet their effectiveness is hindered because of a lack of availability and training.

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This study aimed to evaluate the effects of a media literacy education intervention on adolescents' responses to digital marketing of weight-control products, focusing on media literacy, persuasion resistance efficacy, and purchase intention. Using a quasi-experimental design, the study involved 326 11th-grade students from a municipal high school in Kaohsiung City, Taiwan, with 189 students in the intervention group and 137 in the comparison group. Conducted in 2023, the intervention group participated in baseline and follow-up assessments and attended four 50 min media literacy sessions, while the comparison group completed only baseline and follow-up assessments with standard instruction.

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Background: Neck pain is a significant health concern for unilateral upper limb amputees (UULAs), affecting their functional status and quality of life.

Objectives: To address the neck pain burden that is adding to UULA's pre-existing disability and help Physical therapists to judiciously design and execute effective therapeutic strategies.

Methods: We searched databases for articles till October 23, 2023, and included primary studies reporting neck pain prevalence among UULAs.

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  • Therapeutic plasma exchange (TPE) can lead to low calcium levels due to the use of Anticoagulant Citrate Dextrose Solution A, and adding different concentrations of calcium gluconate to human serum albumin may help prevent this issue.* -
  • A study comparing two groups of TPE procedures found that while intraprocedural calcium levels were similar, post-procedural ionized calcium was significantly lower in the group with less calcium, leading to more cases of symptomatic hypocalcemia and vasovagal reactions.* -
  • The results suggest that using a higher concentration of calcium gluconate (18.6 mg of elemental calcium/100 ml) is safer and more effective in maintaining calcium levels during
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Objective: To investigate the benefits of topical 8% capsaicin patches for the decrease of postsurgical neuropathic pain level and area.

Methods: A systematic review with pooled analysis was conducted utilizing the PRISMA 2020 guidelines. Five commonly used databases were employed utilizing a search string made from MeSH terms and boolean operators.

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Understanding factors influencing the use of specialized outdoor fitness equipment among older adults in Australia.

Health Promot Int

December 2024

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC 3125, Australia.

This study assessed the use of newly installed outdoor fitness equipment (OFE) designed for older adults in two urban parks in Melbourne, Australia, and explored barriers and facilitators to its use among older adults. Direct observations were conducted using System for Observing Play and Recreation in Communities (SOPARC) to assess OFE usage by older adults (≥60 years) at two time points: T1 (November 2021) and T2 (October 2022). Additionally, 140 older adults (60-86 years, 59.

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Factors Influencing Depressive Symptoms in the Post-COVID-19 Pandemic Period.

Cureus

October 2024

Department of Psychological Science, Graduate School of Humanities, Kwansei Gakuin University, Nishinomiya, JPN.

Background Mental health issues associated with the COVID-19 pandemic have been widely reported, with various influencing factors identified. However, factors affecting mental health in the post-pandemic period remain unclear. Therefore, this study aimed to investigate the factors influencing depressive symptoms during the COVID-19 post-pandemic period.

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Impact of COVID-19 pandemic on HTAsiaLink network members.

Int J Technol Assess Health Care

November 2024

Health Intervention and Technology Assessment Program (HITAP), Ministry of Public Health, Thailand.

Objectives: This study investigates the impact of coronavirus disease 2019 (COVID-19) pandemic on HTAsiaLink members at the organizational level and provides recommendations for mitigating similar challenges in the future.

Methods: A survey was disseminated among HTAsiaLink members to assess the COVID-19 impact in three areas: (i) inputs, (ii) process, and (iii) outputs of the Health Technology Assessment organizations' (HTAOs) research operations and HTA process in general.

Results: Survey results showed that most HTAOs hired more staff and secured similar or higher funding levels during COVID-19.

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Background: Intervention trials that have demonstrated significant effects may not always replicate those effects when scaled up. This study aimed to test whether scaling-up a successful cluster randomized trial (the COMMUNICATE study, 9 intervention communities), which promoted population-level physical activity (PA), could promote PA in a broader citywide setting (29 communities) after two years, as a mid-term evaluation of the six-year scaled-up trial.

Methods: This is a single-arm, pre-post comparison of a multi-strategic community-wide intervention covering the entire Unnan City, Japan.

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Simulated spinal durotomy repair for orthopaedic resident training: a perfusion-based porcine cadaveric specimen as an in vitro animal model.

BMC Med Educ

November 2024

Department of Orthopaedic Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Cheng-Kung Road Section 2, Taipei, 114, Taiwan, R.O.C..

Background: Training in delicate spinal dura mater suturing techniques poses significant challenges due to patient safety and medicolegal concerns, driving the need for alternative training methods beyond traditional mentorship models. This study aimed to introduce and validate a training model for orthopaedic residents using perfusion-based porcine spines to simulate intraoperative durotomy and subsequent repair.

Methods: Nine junior orthopaedic residents were invited to participate.

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Tetrabromobisphenol A (TBBPA), a brominated flame retardant (BFR), has been implicated as the neurotoxic effects in mammalian. However, the exact mechanisms underlying TBBPA-induced neurotoxicity remain unclear. In the present study, Neuro-2a cells, a mouse neural crest-derived cell line, were used to examine the mechanism of TBBPA-induced neuronal cytotoxicity.

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Objective: Traumatic brain injury (TBI) prediction models have gained significant attention in recent years because of their potential to aid in clinical decision making. Existing models, such as Corticosteroid Randomization after Significant Head Injury and International Mission for Prognosis and Analysis of Clinical Trials, are currently losing external validity and performance, probably because of their diverse inclusion criteria and changes in treatment modalities over the years. There is a lack of models that predict outcomes strictly pertaining to primary decompression after TBI.

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Background: Psychological phenomena such as impostor phenomenon (IP) and low work-related satisfaction increase the risk of burnout among medical professionals. The prevalence of these contributory risk factors among South Asian medical professionals has not been examined thus far. This study aims to assess the prevalence, severity and associations of IP, including self-reported satisfaction with training, in a cohort of postgraduate doctors in Sri Lanka.

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Hepatitis B small surface protein hijacking Bip is initial and essential to promote lipid synthesis.

J Proteomics

January 2025

State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Institute of Lifeomics, Beijing 102206, PR China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430072, PR China; School of Medicine, Guizhou University, Guiyang 550025, PR China; Graduate School, Anhui Medical University, Hefei 230032, PR China. Electronic address:

To date, the molecular pathogenic mechanisms between HBsAg and liver metabolic disorders have not been fully understood. To explore the overall effects of HBsAg on liver tissues from HBV transgenic mice, proteome, interactome, and signal pathway analysis were employed to uncover the underlying mechanisms. Bioinformatics analysis of 191 differentially expressed proteins suggested that HBV upregulated the expression of multiple enzymes involved in lipid synthesis, and small HBs (SHBs) caused lipid accumulation in cells.

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Background: An eschar is not always present in all scrub typhus patients. Furthermore, such patients may present to tertiary care hospitals after administration of doxycycline. The present study aimed to determine the usefulness of using the swab from eschar sites in the diagnosis of scrub typhus in patients who present post-doxycycline therapy.

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Residential versus day program treatment for eating disorders: A comparison of post-treatment outcomes and predictors.

J Affect Disord

February 2025

Translational Health Research Institute, School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia; Mental Health Services Camden and Campbelltown hospitals, South West Sydney Local Health District, Sydney, Australia. Electronic address:

Both residential and day programs for eating disorders provide options for a step-up from standard outpatient care. However, there have not been any direct comparisons of their effectiveness and limited research on predictors of better outcomes from either setting. This study aimed to compare clinical outcomes and predictors from a transdiagnostic residential and day program for eating disorders.

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Article Synopsis
  • Transplant Renal Artery Stenosis (TRAS) is the most common vascular issue after kidney transplants, linked to higher rates of transplant failure and mortality.
  • A study at a major transplant center focused on identifying risk factors for clinical TRAS (cTRAS) in living donor kidney transplants, revealing that arterial vascular reconstruction of multiple renal arteries (VR-MRA) significantly raises the risk of cTRAS.
  • Among diagnosed cTRAS cases, a majority received successful endovascular treatment, leading to outcomes in graft and patient survival comparable to those without cTRAS, emphasizing the importance of early screening and prompt intervention.
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