Evaluation of serum procathepsin B, cystatin B and cystatin C as possible biomarkers of ovarian cancer.

Objectives: To evaluate procathepsin B, as well as endogenous inhibitors of cysteine proteases (cystatin B and cystatin C) in biological fluids as possible biomarkers of ovarian cancer. To observe levels of serum procathepsin B in different age groups.

Study Design: The sample (N=27) of women with gynaecological tumours included 18 patients with ovarian cancer (n=18) and 9 patients with benign ovarian tumours (n=9); 72 healthy women were in the control group.

Temperature homeostatis and work efficiency in the cold.

The data concerning thermal homeostasis maintenance and energy cost of muscle work in a cold environment and at cold adaptation are presented. It was shown that 10 days' experimental acclimatizing to cold at daily two hour +13 degrees C sessions result in different individual adaptive forms, "euthermic" and "hypothermic", which have specific thermogenesis and body shell vascular reactions in a cold environment. Complex investigations were made on selected groups of people on the basis of professional work with the count of cold exposure time and level of muscular activity in cold.

Regional brain patterns of dopamine, metabolites and D2 receptors in memory.

Patterns of dopamine (DA), 3,4-dihydroxyphenyl acetic (DOPAC), and homovanillic (HVA) acids, para-tyramine (p-TA), and D2 receptors for eleven structures of forebrain and midbrain were examined at 1 and 6 days after one trial passive avoidance training of rats, at 1 day after "psychogenic" amnesia production, immediately following training, and at the last day after foot shock of rats with previous "psychogenic" amnesia administration. Essential dopaminergic differences have been found between the groups studied. More significant neurochemical changes were observed in rats from trained and retrieval training groups.