Mechanism of Phosphorus-Carbon Bond Formation in the Amidoalkylation of Phosphonous Carboxylic Acids.

An unusual greater reactivity of phosphonous propionic acids was found in comparison with phosphonous propionic esters in carbamate version of Kabachnik-Fields reaction. Compounds of tricoordinated phosphorus generated during the amidoalkylation of hydrophosphorylic compounds in acetyl chloride/acetic anhydride mixture were found by P NMR analysis. A hypothesis is proposed about the generation of spirophosphoranes to explain the mechanism for the formation of the phosphorus-carbon bond in the reaction under study.

[The detection of antibodies to endogenous bioregulators for evaluating functional condition of health of portsmen.].

The evaluation of functional condition of health of sportsmen doing Greek Roman wrestling was implemented using detection of level of antibodies to serotonin, histamine, dopamine, glutamate, GABA, orphanine, endorphin, angiotensin. The study established a reliable increasing of level of antibodies to orphanine, β-endorphin, GABA and glutamate under increasing of duration of physical load. The content of antibodies to other regulators of adaptation had no statistical difference.

[Tumor necrosis faсtor-alpha - potential target for neuroprotector dimebon].

Dimebon (Dimebolin) is an antihistamine drug which has been used in Russia since 1983. Recently Dimebolin has attracted renewed interest after being shown to have positive effects on persons suffering from Alzheimer's disease. Animal studies have shown that dimebon acts through multiple mechanisms, both blocking the action of neurotoxic beta-amyloid peptides and inhibiting L-type calcium channels, modulating the action of AMPA and NMDA glutamate receptors.