2 results match your criteria: "Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine[Affiliation]"
Protein kinase C in enhanced vascular tone in diabetes mellitus.
Int J Cardiol
June 2014
Department of Experimental Therapeutics, Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
Diabetes mellitus (DM) is a complex syndrome which leads to multiple dysfunctions including vascular disorders. Hyperglycemia is considered to be a key factor responsible for the development of diabetic vascular complications and can mediate their adverse effects through multiple pathways. One of those mechanisms is the activation of protein kinase C (PKC).
View Article and Find Full Text PDFGap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization.
Cardiovasc Res
August 2013
Department of Experimental Therapeutics, Institute of Pharmacology and Toxicology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
Aims: To determine the role of gap junctions (GJs) in hypoxic pulmonary vasoconstriction (HPV).
Methods And Results: Studies were performed in rat isolated intrapulmonary arteries (IPAs) mounted on a myograph and in anaesthetized rats. Hypoxia induced a biphasic HPV response in IPAs preconstricted with prostaglandin F2α (PGF2α, 3 µM) or 20 mM K⁺.