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Purpose: To evaluate the effect on charge collection in the ionization chamber (IC) in proton pencil beam scanning (PBS), where the local dose rate may exceed the dose rates encountered in conventional MV therapy by up to three orders of magnitude.

Methods: We measured values of the ion recombination (k ) and polarity (k ) correction factors in water, for a plane-parallel Markus TM23343 IC, using the cyclotron-based Proteus-235 therapy system with an active proton PBS of energies 30-230 MeV. Values of k were determined from extrapolation of the saturation curve and the Two-Voltage Method (TVM), for planar fields.

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