3 results match your criteria: "Institute of Novin Tahlilgarane Nesfe-Jahan[Affiliation]"
Bone Repair with Differentiated Osteoblasts from Adipose-derived Stem Cells in Hydroxyapatite/Tricalcium Phosphate In vivo.
Int J Prev Med
May 2016
Department of Surgery, Amine Hospital, Isfahan, Iran; Institute of Novin Tahlilgarane Nesfe-Jahan, Isfahan, Iran.
Background: Recently, tissue engineering has developed approaches for repair and restoration of damaged skeletal system based on different scaffolds and cells. This study evaluated the ability of differentiated osteoblasts from adipose-derived stem cells (ADSCs) seeded into hydroxyapatite/tricalcium phosphate (HA-TCP) to repair bone.
Methods: In this study, ADSCs of 6 canines were seeded in HA-TCP and differentiated into osteoblasts in osteogenic medium in vitro and bone markers evaluated by reverse transcription polymerase chain reaction (RT-PCR).
Article Synopsis
- During adolescence, sex hormones, particularly estrogen, influence the development and regulation of cartilage cells called chondrocytes, but the specific mechanisms remain partially understood.
- The study utilized adipose-derived stem cells (ADSCs) to investigate how estrogen affects the expression of cartilage-specific genes during the chondrogenesis process, comparing control and experimental groups.
- Results showed that estrogen inhibits the expression of type II collagen and reduces aggrecan gene expression, suggesting that estrogen may have negative effects on the formation of cartilage from ADSCs.
An animal model study for bone repair with encapsulated differentiated osteoblasts from adipose-derived stem cells in alginate.
Iran J Basic Med Sci
November 2014
Cancer Prevention Research Center, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran ; Institute of Novin Tahlilgarane Nesfe-jahan, Isfahan, Iran.
Objectives: Adipose derived stem cells (ADSCs) can be engineered to express bone specific markers. The aim of this study is to evaluate repairing tibia in animal model with differentiated osteoblasts from autologous ADSCs in alginate scaffold.
Materials And Methods: In this study, 6 canine's ADSCs were encapsulated in alginate and differentiated into osteoblasts.