41,269 results match your criteria: "Institute of Neuroscience[Affiliation]"
BMC Oral Health
December 2024
Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Background: How common it is with the presence of human papillomavirus (HPV) in the healthy and diseased oral cavity is largely unknown for Africans. In this cross-sectional study we assessed the prevalence of oral HPV and the risk factors associated with HPV contraction including sexual practice in the urban and rural Zambian population.
Methods: Urban (N = 188) and rural (N = 211) Zambian adults aged 21 years and older living in Ndola and Mansa, respectively, were interviewed about demographical data, oral and coital sexual history and tobacco and alcohol use.
Compr Psychiatry
December 2024
Department of Physical Medicine and Rehabilitation, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan; Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:
Background: Over 25 % of bipolar disorder (BD) patients are misdiagnosed with major depressive disorder (MDD). An urgent need exists for a biomarker to differentiate BD from MDD. Various manifestations and intensities of maladaptive guilt processing might uniquely contribute to the pathogenesis of BD compared to MDD.
View Article and Find Full Text PDFCell Rep
December 2024
Institute of Neuroscience, Key Laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China. Electronic address:
In the dorsal striatum (DS), the direct- and indirect-pathway striatal projection neurons (dSPNs and iSPNs) play crucial opposing roles in controlling actions. However, it remains unclear whether and how dSPNs and iSPNs provide distinct and specific contributions to decision-making, a process transforming sensory inputs to actions. Here, we perform causal interrogations on the roles of dSPNs and iSPNs in the posterior DS (pDS) in auditory-guided decision-making.
View Article and Find Full Text PDFMol Psychiatry
December 2024
Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.
The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis. Two recently developed post hoc ancestry adjustment methods of Polygenic Risk Scores (PRSs) generate Ancestry-Adjusted PRSs (AAPRSs), which allow for PRS analysis of multi-ancestry samples.
View Article and Find Full Text PDFJ Neurosci Methods
December 2024
Laboratoire des Systèmes Perceptifs, Département d'Étude Cognitive, École Normale Supérieure, PSL, Paris, France; Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, USA.
Background: IDyOM (Information Dynamics of Music) is the statistical model of music the most used in the community of neuroscience of music. It has been shown to allow for significant correlations with EEG (Marion, 2021), ECoG (Di Liberto, 2020) and fMRI (Cheung, 2019) recordings of human music listening. The language used for IDyOM -Lisp- is not very familiar to the neuroscience community and makes this model hard to use and more importantly to modify.
View Article and Find Full Text PDFProg Neurobiol
December 2024
Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, 52425 Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich-Heine-University, 40225 Dusseldorf, Germany.
Neurotransmitter receptors are key molecules in signal transmission in the adult brain, and their precise spatial and temporal balance expressions also play a critical role in normal brain development. However, the specific balance expression of multiple receptors during hippocampal development is not well characterized. In this study, we used quantitative in vivo receptor autoradiography to measure the distributions and densities of 18 neurotransmitter receptor types in the mouse hippocampal complex at postnatal day 7, and compared them with the expressions of their corresponding encoding genes.
View Article and Find Full Text PDFAm J Hum Genet
December 2024
Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, the Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, Guangdong, China. Electronic address:
J Neurol Sci
December 2024
Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan; Multiple Sclerosis Center, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address:
Background: The ASCLEPIOS/APLIOS/APOLITOS/ALITHIOS trials highlighted the benefits of ofatumumab in reducing relapse rates and disability progression in multiple sclerosis (MS). However, its effects on patients with severe disability status remains uncertain. This study aimed to clarify the outcomes of ofatumumab in MS patients with high Expanded Disability Status Scale (EDSS) scores and prolonged disease durations.
View Article and Find Full Text PDFClin Neurophysiol
December 2024
Université de Lorraine, CNRS, IMoPA, 29 Avenue du Maréchal de Lattre de Tassigny, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Service de Neurologie, 29 Avenue du Maréchal de Lattre de Tassigny, F-54000 Nancy, France. Electronic address:
Objective: Combining electroencephalographic (EEG) recording and fast periodic visual stimulation (FPVS) to provide an implicit, objective and sensitive electrophysiological measure of semantic word categorization impairment in Alzheimer's Disease (AD).
Methods: Twenty-five AD patients and 25 matched elderly healthy controls were tested with a validated FPVS-EEG paradigm in which different written words of the same semantic category (cities) appear at a fixed frequency of 4 words per second (4 Hz) for 70 seconds. Words from a different semantic category (animal) appear every 4 stimuli (i.
Disabil Rehabil Assist Technol
December 2024
Department of Clinical Neuroscience, Sahlgrenska Academy, Institute of Neuroscience and Physiology, Gothenburg, Sweden.
Persons living with spinal cord injury (SCI) often lacks access to outdoor mobility, which can significantly impact their ability to participate in activities outside the home, to take part in their community, and to have meaningful occupations and relationships with loved ones. To better understand the importance of outdoor mobility for persons with SCI, the aim of this cross-sectional study was to explore transport modes, car adaptations, and their perceived function and safety. A web-survey, addressing outdoor mobility and driving, was distributed among people with different physical impairments.
View Article and Find Full Text PDFJ Neurol
December 2024
Department of Neurology, Essen University Hospital, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Background: Cognitive and neuropsychiatric impairment, known as cerebellar cognitive affective syndrome (CCAS), may be present in cerebellar disorders. This study identified distinct CCAS subtypes in cerebellar patients using cluster analysis.
Methods: The German CCAS-Scale (G-CCAS-S), a brief screening test for CCAS, was assessed in 205 cerebellar patients and 200 healthy controls.
Sleep
December 2024
Department of Neurology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China.
Lancet Neurol
January 2025
Departments of Internal Medicine, Microbiology & Immunology, Western Institute of Neuroscience, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5K8, Canada. Electronic address:
Early Hum Dev
December 2024
Children's Hospital Los Angeles, Department of Neurology, United States of America.
Objective: We examined whether early medical factors predicted variability in developmental level and trajectories in high-risk neonatal intensive care unit (NICU) graduates during the first year of life.
Method: Infants (n = 53) who met criteria for the High-Risk Infant Follow-up Program were enrolled. Simple linear models predicted 12-month developmental abilities and linear mixed models predicted 6- to 12-month trajectories based on length of NICU stay and birthweight.
Neurology
January 2025
From the Center for Stroke Research Berlin (I.G., J.B.F.), Charité-Universitätsmedizin Berlin, Germany; Service de Biostatistique (F.B., P.R.), Hospices Civils de Lyon, France; Department of Neurology (B.C., C.G., G.T.), University Medical Center Hamburg-Eppendorf, France; Department of Stroke Medicine (T.-H.C.), Université Claude Bernard Lyon 1, Hospices Civils de Lyon, France; Neurologie der Rehaklinik Medical Park Humboldtmühle (M. Ebinger), Berlin; Klinik und Hochschulambulanz für Neurologie (M. Endres), Charité-Universitätsmedizin Berlin; Center for Stroke Research Berlin (M. Endres); German Center for Neurodegenerative Diseases (DZNE), partner site Berlin (M. Endres); German Centre for Cardiovascular Research (DZHK), partner site Berlin (M. Endres); German Center for Mental Health (DZPG), partner site Berlin (M. Endres), Germany; Department of Neurology (C.E.), Medical University of Graz, Austria; Department of Diagnostic and Interventional Neuroradiology (J.F.), Universitätsklinikum Hamburg-Eppendorf, Germany; Robertson Centre for Biostatistics (I.F.), University of Glasgow, Scotland; mediri GmbH (J.G.); Fraunhofer Institute for Digital Medicine MEVIS (M.G.), Bremen, Germany; Department of Neurosciences (R.L., A.W.), Experimental Neurology, KU Leuven-University of Leuven, Belgium; School of Psychology & Neuroscience (K.W.M.), University of Glasgow, Scotland; Department of Stroke Medicine (N.N.), Université Claude Bernard Lyon 1, and Hospices Civils de Lyon, France; Department of Neurology (C.Z.S.), Aarhus University Hospital, Denmark; Florey Institute of Neuroscience and Mental Health (V.N.T.), Heidelberg, Australia; and Institut d'Investigació Biomèdica de Girona (S.P.), Hospital Universitari Doctor Josep Trueta, Girona, Spain.
Background And Objectives: Data from randomized trials on the treatment effect of pure thrombolysis in patients with vessel occlusion are lacking. We examined data from a corresponding subsample of patients from the multicenter, randomized, placebo-controlled WAKE-UP trial to determine whether MRI-guided IV thrombolysis with alteplase in unknown-onset ischemic stroke benefits patients presenting with vessel occlusion.
Methods: Patients with an acute ischemic lesion visible on MRI diffusion-weighted imaging but no marked parenchymal hyperintensity on fluid-attenuated inversion recovery images were randomized to treatment with IV alteplase or placebo.
Hum Brain Mapp
December 2024
Institute of Systems Neuroscience, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
The human hippocampus is a key region in cognitive and emotional processing, but also a vulnerable and plastic region. Accordingly, there is a great interest in understanding how variability in the hippocampus' structure relates to variability in behavior in healthy and clinical populations. In this study, we aimed to link interindividual variability in subregional hippocampal networks (i.
View Article and Find Full Text PDFDev Sci
January 2025
Division of Neurology and Neurological Institute, The Children's Hospital of Los Angeles, Los Angeles, California, USA.
Electroencephalography (EEG) captures characteristic oscillatory shifts in infant brain rhythms over the first year of life, offering unique insights into early functional brain development and potential markers for detecting neural differences associated with autism. This study used functional principal component analysis (FPCA) to derive dynamic markers of spectral maturation from task-free EEG recordings collected at 3, 6, 9, and 12 months from 87 infants, 51 of whom were at higher likelihood of developing autism due to an older sibling diagnosed with the condition. FPCA revealed three principal components explaining over 96% of the variance in infant power spectra, with power increases between 6 and 9 Hz (FPC1) representing the most significant age-related trend, accounting for more than 71% of the variance.
View Article and Find Full Text PDFStem Cells
December 2024
Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.
Human induced pluripotent stem cells (iPSCs) provide powerful cellular models of Alzheimer's disease (AD) and offer many advantages over non-human models, including the potential to reflect variation in individual-specific pathophysiology and clinical symptoms. Previous studies have demonstrated that iPSC-neurons from individuals with Alzheimer's disease (AD) reflect clinical markers, including β-amyloid (Aβ) levels and synaptic vulnerability. However, despite neuronal loss being a key hallmark of AD pathology, many risk genes are predominantly expressed in glia, highlighting them as potential therapeutic targets.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Introduction: This study investigated the associations of brain age gap (BAG)-a biological marker of brain resilience-with life exposures, neuroimaging measures, biological processes, and cognitive function.
Methods: We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.
Commun Biol
December 2024
Department of Life Sciences and Institute of Genome Sciences, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan (ROC).
During embryogenesis, vertebral axial patterning is intricately regulated by multiple signaling networks. This study elucidates the role of protogenin (Prtg), an immunoglobulin superfamily member, in vertebral patterning control. Prtg knockout (Prtg) mice manifest anterior homeotic transformations in their vertebral columns and significant alterations in homeobox (Hox) gene expression.
View Article and Find Full Text PDFPediatr Res
December 2024
The Sahlgrenska Centre for Pediatric Ophthalmology Research, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Background: Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels of arachidonic acid (AA) and docosahexaenoic acid (DHA). To date, these risk factors have not been linked.
Method: Infants born < 28 weeks gestational age (GA) from 2016 to 2019 were randomized to postnatal enteral AA/DHA supplementation or standard care (controls).
Commun Biol
December 2024
Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa, Ontario, ON, Canada.
Recent neuroimaging studies demonstrate a heterogeneity of timescales prevalent in the brain's ongoing spontaneous activity, labeled intrinsic neural timescales (INT). At the same time, neural timescales also reflect stimulus- or task-related activity. The relationship of the INT during the brain's spontaneous activity with their involvement in task states including behavior remains unclear.
View Article and Find Full Text PDFJ Expo Sci Environ Epidemiol
December 2024
Department of Health Sciences, Karlstad University, Karlstad, Sweden.
Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture.
Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficulties.
BMC Geriatr
December 2024
Universidad de los Andes, Escuela de Gobierno Alberto Lleras Camargo, Carrera 1° N° 19-27. Bloque AU, Piso 2, Bogotá, 111711, Colombia.
Introduction: Dementia, an increasingly critical public health concern in low and middle-income countries, is associated with lower socioeconomic status, early cognitive impairment, and elevated dementia-related mortality risk. This study seeks to estimate the prevalence of cognitive impairment, investigate its links with social indicators, and visualize social gradients across different regions in Colombia.
Methods: Secondary data analysis from the SABE 2015 survey, multinomial regression analyses, and equiplot graphs.
Trends Neurosci
December 2024
Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:
Recent studies in non-human primates do not find pronounced signals related to the animal's own body movements in the responses of neurons in the visual cortex. This is notable because such pronounced signals have been widely observed in the visual cortex of mice. Here, we discuss factors that may contribute to the differences observed between species, such as state, slow neural drift, eccentricity, and changes in retinal input.
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