5 results match your criteria: "Institute of Neuropsychiatry and Medical School of Southeast University[Affiliation]"
Corrigendum to "Abnormal brain gray matter volume in patients with major depressive disorder: Associated with childhood trauma?" [J. Affect. Disord. Volume 308, 1 July 2022, 562-568].
J Affect Disord
August 2022
Department of Psychology, Xinxiang Medical University, Henan 453003, China; Xinxiang Key Laboratory of Psychopathology and Cognitive Neuroscience, Xinxiang 453003, China; Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China. Electronic address:
Abnormal brain gray matter volume in patients with major depressive disorder: Associated with childhood trauma?
J Affect Disord
July 2022
Department of Psychology, Xinxiang Medical University, Henan 453003, China; Xinxiang Key Laboratory of Psychopathology and Cognitive Neuroscience, Xinxiang 453003, China; Department of Psychiatry, Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453002, China. Electronic address:
Background: Patients with major depressive disorders (MDD) have abnormalities in the frontal-limbic structures of the brain. Childhood trauma is a risk factor for both structural brain alterations and MDD. However, the relationships among the three have not been confirmed.
View Article and Find Full Text PDFAltered task modulation of global signal topography in the default-mode network of unmedicated major depressive disorder.
J Affect Disord
January 2022
Department of Neurology of Affiliated ZhongDa Hospital, Institute of Neuropsychiatry and Medical School of Southeast University, Nanjing 210009, Jiangsu Province, China; Royal Ottawa Mental Health Centre, University of Ottawa(,) Institute of Mental Health Research(,) Ottawa(,) Ontario K1Z 7K4, Canada; Mental Health Center, Zhejiang University School of Medicine, Hangzhou 310013, Zhejiang Province, China; Brain and Mind Research Institute, Centre for Neural Dynamics, Faculty of Medicine, University of Ottawa(,) Ottawa, Ontario K1Z 7K4(,) Canada; Centre for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou 310013, Zhejiang Province, China. Electronic address:
Article Synopsis
- The study looked at brain activity in people with major depressive disorder (MDD) using fMRI to understand how they process emotions, especially negative ones.
- It found that when healthy people react to emotions quickly, their brain shows strong connections, but people with MDD have weaker connections under the same conditions.
- The results suggest that people with MDD might have a slower reaction time in their brains, which relates to their symptoms like feeling sluggish or having trouble with motor skills.
Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex.
Sci China Life Sci
January 2021
Department of Neurology of Affiliated Zhongda Hospital, Institute of Neuropsychiatry and Medical School of Southeast University, Nanjing, 210009, China.
To determine whether repetitive transcranial magnetic stimulation (rTMS) of the visual cortex (VC) provides effective and well-tolerated treatment and whether magnetic resonance imaging (MRI) measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder (MDD), we performed a sham-controlled, double-blind, randomized, three-arm VC rTMS treatment study in 74 MDD patients. Neuronavigated rTMS (10 Hz, 90% of resting motor threshold, 1,600 pulses over 20 min twice per day) was performed over the VC for five days. Clinical outcome was measured by Hamilton Depression Rating Scale (HAMD-24) at days 0, 1, 3, 5 and after terminating rTMS, with follow-up at four weeks.
View Article and Find Full Text PDFFluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro.
Neuroscience
May 2015
The Department of Neurology of Affiliated ZhongDa Hospital, The Institute of Neuropsychiatry and Medical School of Southeast University, Nanjing, China. Electronic address:
Increasing evidence has suggested that microglia dysfunction plays an important role in the pathogenesis of depression. Both classical activation (M1 activation) and alternative activation (M2 activation) may be involved in the process. M1-activated microglia secrete various pro-inflammatory cytokines and neurotoxic mediators, which may contribute to the development of depression, while M2-activated microglia promote tissue reconstruction by releasing anti-inflammatory cytokines involved in the process of depression.
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