A polyoxomolybdate-based hybrid nano capsule as an antineoplastic agent.

Polyoxometalates (POMs) are versatile anionic clusters which have attracted a lot of attention in biomedical investigations. To counteract the increasing resistance effect of cancer cells and the high toxicity of chemotherapeutic treatments, POM-based metallodrugs can be strategically synthesized by adjusting the stereochemical and physicochemical features of POMs. In the present report a polyoxomolybdate (POMo) based organic-inorganic hybrid solid (CHN)(CHN)[MoO]·3HO, solid 1, has been synthesized and its antitumoral activities have been investigated against three cancer cell lines namely, A549 (Lung cancer), HepG2 (Liver cancer), and MCF-7 (Breast cancer) with IC50 values 56.

A rare polyoxometalate cluster [NiWO] based solid as a pre-catalyst for efficient and long-term oxygen evolution.

Polyoxometalates (POMs) are an eminent class of metal oxide anionic clusters of early transition metals with huge structural diversity. Herein, a [NiWO] cluster based solid, (CHN)[NiWO], has been reported (PS-78). The [NiWO] cluster bridges the missing gap of 1 : 12 hetero-POMs of Keggin and Silverton together with a coordination number of 8 of the central heteroatom (Ni).

Self-assembly of copper nanoclusters: isomeric ligand effect on morphological evolution.

Tailoring the hierarchical self-assembly of metal nanoclusters (NCs) is an emergent area of research owing to their precise structure and flexible surface environment. Herein, the morphological evolution from rods to platelets to ribbon-like structures through self-assembly of Cu NCs is dictated by the positional isomerism of the surface capping ligand, dimethylbenzenethiol (DMBT). Besides cuprophilic interaction, the interplay between π-π stacking and agostic interaction (Cu⋯H-C) directs the inter-NC organization into different ordered architectures.

Effect of manganese doping on the hyperthermic profile of ferrite nanoparticles using response surface methodology.

Magnetic hyperthermia-based cancer therapy mediated by magnetic nanomaterials is a promising antitumoral nanotherapy, owning to its power to generate heat under the application of an alternating magnetic field. However, although the ultimate targets of these treatments, the heating potential and its relation with the magnetic behavior of the employed magnetic nanomaterials are rarely studied. Here we provide a bridge between the heating potential and magnetic properties such as anisotropy energy constant and saturation magnetization of the nano-magnets by simultaneous investigation of both hyperthermia and magnetism under a controlled set of variables given by response surface methodology.

Therapeutic response differences between 2D and 3D tumor models of magnetic hyperthermia.

Magnetic hyperthermia-based cancer therapy (MHCT) has surfaced as one of the promising techniques for inaccessible solid tumors. It involves generation of localized heat in the tumor tissues on application of an alternating magnetic field in the presence of magnetic nanoparticles (MNPs). Unfortunately, lack of precise temperature and adequate MNP distribution at the tumor site under conditions has limited its application in the biomedical field.

Large piezoelectric and thermal expansion coefficients with negative Poisson's ratio in strain-modulated tellurene.

Two dimensional (2D) chalcogenide monolayers have diversified applications in optoelectronics, piezotronics, sensors and energy harvesting. The group-IV tellurene monolayer is one such emerging material in the 2D family owing to its piezoelectric, thermoelectric and optoelectronic properties. In this paper, the mechanical and piezoelectric properties of 2D tellurene in centrosymmetric β and non-centrosymmetric β' phases are investigated using density functional theory.