4 results match your criteria: "Institute of Microbiology of the Czech Academy of Sciences - Center Algatech[Affiliation]"
Hibberdia magna (Chrysophyceae): a promising freshwater fucoxanthin and polyunsaturated fatty acid producer.
Microb Cell Fact
April 2023
Laboratory of Algal Biotechnology, Institute of Microbiology of the Czech Academy of Sciences - Center Algatech, Trebon, Czech Republic.
Article Synopsis
- Algae are valuable sources of compounds like fucoxanthin and polyunsaturated fatty acids, which have applications in food and pharmaceuticals; however, most research focuses on marine species, with less exploration of freshwater options.
- The study specifically identifies the freshwater alga Hibberdia magna as a potential producer of fucoxanthin (up to 1.2% of dry biomass) and polyunsaturated fatty acids (up to 9.9% of dry biomass) through controlled cultivation experiments.
- Optimal growing conditions vary; fucoxanthin is best produced in dim light and moderate temperatures, while higher yields of polyunsaturated fatty acids and overall
Screening of the Medicines for Malaria Venture Pandemic Response Box for Discovery of Antivirulent Drug against Pseudomonas aeruginosa.
Microbiol Spectr
December 2022
Laboratory of Algal Biotechnology, Institute of Microbiology of the Czech Academy of Sciences-Center Algatech, Třeboň, Czech Republic.
Resistance development and exhaustion of the arsenal of existing antibacterial agents urgently require an alternative approach toward drug discovery. Herein, we report the screening of Medicines for Malaria Venture (MMV) Pandemic Response Box (PRB) through a cascade developed to streamline the potential compounds with antivirulent properties to combat an opportunistic pathogen, Pseudomonas aeruginosa. To find an agent suppressing the production of P.
View Article and Find Full Text PDFNew Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency.
Chembiochem
January 2022
Institute of Microbiology of the Czech Academy of Sciences - Center Algatech, Novohradska 237, 37981, Trebon, Czech Republic.
Scytophycins, including tolytoxin, represent a class of actin disrupting macrolides with strong antiproliferative effects on human cells. Despite intense research, little attention has been paid to scytophycin-induced cell death or the structural features affecting its potency. We show that tolytoxin and its natural analogue, 7-O-methylscytophycin B, lacking the hydroxyl substitution in its macrolactone ring, differ substantially in their cytotoxic effect.
View Article and Find Full Text PDFQuorum-Sensing Signals from Epibiont Mediate the Induction of Novel Microviridins in the Mat-Forming Cyanobacterial Genus .
mSphere
August 2021
Laboratory of Algal Biotechnology, Institute of Microbiology of the Czech Academy of Sciences-Center Algatech, Trebon, Czech Republic.
Article Synopsis
- The regulation of oligopeptide production is crucial for understanding their ecological impacts, particularly in harmful cyanobacterial blooms and interactions with microbial communities.
- Research reveals that bacterial epibionts influence the production of microviridins, which may have anti-grazing properties, through a quorum-sensing mechanism.
- The findings suggest that these chemical interactions facilitate specific metabolic responses among cyanobacteria, indicating the need for further exploration into cyanopeptides and their effects on aquatic ecosystems and human health.