2 results match your criteria: "Institute of Microbiology Friedrich Schiller University[Affiliation]"
Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multi-locus sequence typing scheme: a retrospective observational and genomic epidemiology study.
Lancet Microbe
November 2024
Institute of Microbiology Friedrich Schiller University Jena, Jena, Germany; Cluster of Excellence Balance of the Microverse Friedrich Schiller University Jena, Jena, Germany. Electronic address:
Article Synopsis
- Fluconazole-resistant Candida parapsilosis is a growing concern in healthcare settings, leading to outbreaks similar to those caused by Candida auris, with a notable outbreak documented in Berlin from late 2018 through 2022.
- A retrospective study employed whole-genome sequencing (WGS) to analyze samples from various healthcare facilities to track the spread and resistance patterns of this pathogen.
- The research aimed to create a reliable multi-locus sequence typing (MLST) system to better understand and monitor the outbreak, using patient records and genomic data to analyze transmission dynamics.
The NiFe Hydrogenases of the Tetrachloroethene-Respiring Epsilonproteobacterium : Biochemical Studies and Transcription Analysis.
Front Microbiol
March 2017
Department of Applied and Ecological Microbiology, Institute of Microbiology Friedrich Schiller University, Germany.
The organohalide-respiring Epsilonproteobacterium is able to grow with hydrogen as electron donor and with tetrachloroethene (PCE) as electron acceptor; PCE is reductively dechlorinated to -1,2-dichloroethene. Recently, a genomic survey revealed the presence of four gene clusters encoding NiFe hydrogenases in its genome, one of which is presumably periplasmic and membrane-bound (MBH), whereas the remaining three are cytoplasmic. To explore the role and regulation of the four hydrogenases, quantitative real-time PCR and biochemical studies were performed with cells grown under different growth conditions.
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