Biogenic Synthesis and Characterization of Silver Nanoparticles With Cyanobacterium Oscillatoria salina Using Against MDR Pathogenic Bacteria and Their Antiproliferative and Toxicity Study.

The biosynthesis of silver nanoparticles (AgNPs) using cyanobacteria has gained significant attention due to its cost-effective and eco-friendly advantages in green synthesis. Additionally, biogenic AgNPs show great potential for biological applications, particularly in combating infections caused by drug-resistant bacteria and fungi. This study synthesized using the cyanobacterium Oscillatoria salina (Os-AgNPs).

Serological comparison of weak D versus weakly reacting D by four different methods.

Introduction: Weak D red cells were defined as having a reduced amount of D antigen (formerly called "Du") that required an indirect antiglobulin test (IAT) for detection. Weakly reacting D is those which give <2+ reactions on routine methods. The present study is sharing our experience on weak D and weakly positive anti-D in various methods.

Integrating Network Pharmacology and In Silico Analysis to Explore the Bioactive Compounds Against Gastric Cancer Treatment.

Gastric cancer (GC) has become a major challenge in oncology research, primarily due to its detection at advanced stages. In this study, we identified and validated the pharmacological mechanisms involved in treating gastric cancer using an integrated approach combining network pharmacology, molecular docking, and a dynamic approach. Gastric cancer-related genes were obtained from DisGeNET, Genecard, and Malacard databases, while potential targets of bioactive compounds were predicted using SwissTargetPrediction.

Assessment of Knowledge, Awareness, and Practices of Human Papillomavirus Infection and Vaccination Among Medical and Dental Students: A Cross-Sectional Study.

Introduction Human papillomavirus (HPV) is the most common causative agent for cervical cancer (CC) in women. Despite extensive initiatives, the acceptance and implementation of vaccinations have remained inadequate, hindering a significant impact on public health outcomes. This study aimed to provide a comprehensive assessment of the knowledge, awareness, and practices (KAP) scores of medical and dental students regarding HPV infection and vaccination.

Pulmonary tuberculosis presenting as a hilar mass.

Tuberculosis (TB) is a great mimicker due to its various unusual and atypical presentations. Mass-like lesions in thoracic radiology may raise the suspicion of lung malignancy. A man in his early 50s complained of cough, low-grade fever and dyspnoea.

The Development of Ebola Virus Outbreaks: A Review of Epidemiological Trends, Clinical Features, and Treatment Advances.

The Ebola virus, a filovirus that causes human Ebola virus disease (EVD), has caused multiple epidemics in the African continent for about 50 years. Wild animals were the source from which the virus was transmitted to humans, and it spread among people through direct contact. The majority of Ebola outbreaks occurred in African nations, particularly in Sudan, the Democratic Republic of the Congo (DRC), Uganda, and Gabon.

Evaluating the Impact of Adjustable- and Fixed-Loop Femoral Endobuttons on Intraoperative Surgeon Satisfaction and Postoperative Patient Functional Outcomes in Anterior Cruciate Ligament (ACL) Reconstruction.

Introduction: This study aims to evaluate the effects of adjustable- and fixed-loop femoral endobuttons on intraoperative surgeon satisfaction and postoperative patient functional outcomes in anterior cruciate ligament (ACL) reconstruction. The use of cortical suspensory devices, either fixed-loop or adjustable-loop, is common in ACL reconstruction surgeries for femoral tunnel fixation. Fixed-loop devices, although effective, often require additional tunnel drilling, potentially leading to tunnel widening.

Neuromodulation techniques in traumatic brain injury: a narrative review of the current state.

Traumatic brain injury (TBI) is a leading cause of death and disability throughout the world. Despite significant advances in medical care, many TBI survivors continue to have cognitive, physical, and psychological deficits that have a significant impact on their quality of life. Neuromodulation techniques, which use electrical or magnetic stimulation to modulate brain activity, have shown promise in the treatment of TBI symptoms.

Do the fathers matter? Paternal perspective of exclusive breastfeeding practices: A community-based cross-sectional study in urban slums of Bhubaneswar, Odisha.

Introduction: Although various policies have been framed to improve exclusive breastfeeding outcomes in India, the father's role in breastfeeding is grossly ignored. Gender inequalities are still predominant in several parts of India. Fathers' involvement in breastfeeding decision-making plays a significant role in improving the outcome.

Neuroprotective effect of Bacillus subtilis in haloperidol induced rat model, targeting the microbiota-gut-brain axis.

Functional microbes regulate Parkinson's disease (PD), according to contemporary research. The mechanism by which probiotics (PBT) improve PD was not fully explored yet. We examined the antioxidant impact and mechanism of PBT (Bacillus subtilis) on PD using gut-brain axis regulation.

Progressive Supranuclear Palsy in India: Past, Present, and Future.

Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over the past several decades. This review meticulously explores the extensive range of Indian research on PSP up to the present and offers insights into both current initiatives and potential future directions for managing PSP within the region. Historical research contributions have spanned 80 publications from 1974 to 2023, encompassing diverse themes from clinical phenotyping and historical analysis to isolated investigative studies and therapeutic trials.

Incomplete Kawasaki Disease in an Adult Complicated by Stroke.

Kawasaki disease (KD) is a systemic vasculitis with an unclear origin primarily affecting young children. The sole difference between complete and incomplete KD upon presentation is the number of signs and symptoms. There is a concerning case of a 50-year-old male with incomplete KD who has additionally presented with a stroke.

Safety and immunogenicity of a pentavalent meningococcal conjugate vaccine versus a quadrivalent meningococcal conjugate vaccine in adults in India: an observer-blind, randomised, active-controlled, phase 2/3 study.

Background: Meningococcal disease remains an important public health problem globally. We assessed the non-inferiority and the lot-to-lot consistency of a pentavalent meningococcal ACYWX conjugate vaccine (NmCV-5; Serum Institute of India, Pune, India) versus a quadrivalent meningococcal ACWY conjugate vaccine (MenACWY-D) in healthy adults.

Methods: In this observer-blind, randomised, active-controlled, phase 2/3 study, healthy adults aged 18-85 years were recruited from nine hospitals across seven cities in India.

Unveiling the interaction, cytotoxicity and antibacterial potential of pyridine derivatives: an experimental and theoretical approach with bovine serum albumin.

The binding interactions between bovine serum albumin (BSA) and three pyridine derivatives, i.e., 2-(5-bromopyridin-3-yl) acetic acid (L1), 3-bromo-5-nitropyridine (L2) and 2-chloro-4-nitropyridine (L3), have been carried out using UV-Vis and fluorescence spectroscopic methods.

Artificial Intelligence Assisted Surgical Scene Recognition: A Comparative Study Amongst Healthcare Professionals.

Objective: This study aimed to compare the ability of a deep-learning platform (the MACSSwin-T model) with healthcare professionals in detecting cerebral aneurysms from operative videos. Secondly, we aimed to compare the neurosurgical team's ability to detect cerebral aneurysms with and without AI-assistance.

Background: Modern microscopic surgery enables the capture of operative video data on an unforeseen scale.

Burden of vaso-occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients.

Sickle cell disease (SCD) with vaso-occlusive pain crisis (VOC) significantly impacts patient well-being and often results in extensive healthcare resource utilization. This study assessed the VOC burden, its management and its impact on patients' quality of life (QoL). A cross-sectional observational study was conducted between November 2021 and June 2022, including 1000 SCD patients from high-prevalence states in India.

Scrub typhus presenting with massive splenomegaly and lobar pneumonia.

Scrub typhus is still an underdiagnosed disease despite an increase in incidence as the clinical presentation is often different, leading to a low index of suspicion among doctors. Scrub typhus, an acute febrile disease, is a cause of prolonged fever and pyrexia of unknown origin. It can have varied clinical presentations ranging from mild asymptomatic disease to fatal multi-organ dysfunction.

Assessment of Diaphragmatic Dysfunction in Mechanically Ventilated Patients with Ultrasonography.

Introduction: The reliability of the diaphragm thickening fraction in predicting weaning failure in mechanically ventilated patients in the intensive care unit (ICU), as well as the relationship between the patients' diaphragmatic inspiratory excursion and diaphragmatic thickness.

Materials And Methods: Fifty mechanically ventilated patients participated in this hospital-based cross-sectional prospective study in a tertiary care teaching hospital. Patients who had been on a mechanical ventilator for at least 7 days and whose legal guardian was willing to provide consent were also included in the research.

Changes in Smoking Patterns in Turkey Before and After the Ban on Loose Cigarettes: An Ecological Perspective From Global Tobacco Surveillance Data.

Introduction: Loose or individual cigarettes sold without packaging pose a unique challenge for tobacco control, which is the leading cause of premature and preventable mortality worldwide. This study aims to assess the changes in smoking patterns following the ban on loose cigarettes in 2008 in Turkey.

Method: Gender-stratified trend analysis of smoking patterns before and after the ban on loose cigarettes was done using the Global Tobacco Surveillance data (adults: Global Adult Tobacco Survey (GATS) 2008, 2012, and 2016; youth: Global Youth Tobacco Survey (GYTS) 2003, 2005, 2009, 2012, and 2017) from Turkey.

Correlation of Endoscopic and Histopathological Diagnoses in Upper Gastrointestinal Tract Lesions: A Cross-Sectional Study.

Introduction Gastrointestinal tract (GIT) endoscopy with biopsy is essential for diagnosing and managing various GIT diseases, including malignancies and inflammatory conditions. This study aimed to analyze the spectrum of histopathological lesions in the GIT and their correlation with the endoscopic findings. Methodology This retrospective observational study was conducted at a tertiary medical college involving 114 patients who underwent GIT endoscopy between June 2023 and June 2024.