Design and Validation of Endophthalmitis Infectivity Measurement Algorithm in Post Cataract Acute Endophthalmitis: EMS Report No. 6.

Purpose: We constructed a clinical clue-based algorithm to identify the microbiology-positive post-cataract surgery endophthalmitis.

Methods: The Endophthalmitis Infectivity Measurement Algorithm (EIMA) was constructed using presenting Snellen vision (Letter score [LS]) and Inflammation Score (IS, from the cornea, anterior chamber, iris, and vitreous). Retrospective data (70% for training; 30% for testing) was fitted into CHAID (Chi-squared Automatic Interaction Detection).

Infantile (congenital) anaplastic intracranial solitary fibrous tumor/hemangiopericytoma-A case report with brief literature review.

Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare primary central nervous system (CNS) tumor, included in the World Health Organization (WHO) 2016 classification. Very few cases have been described in the literature so far, especially the infantile type. It is a mesenchymal tumor of the fibroblastic type, characterized by the fusion of NAB 2 and STAT 6 genes.

Neonatal Meningitis Secondary to Infection.

Introduction: , a rare cause of sepsis and meningitis in neonates, often associated with a wide spectrum of clinical presentation. The objective of the study was to describe the clinical characteristics and outcome of neonates, who developed meningitis secondary to infection at a tertiary care Neonatal unit in India.

Methods: This retrospective study was conducted in the neonatal unit of a tertiary care hospital in New Delhi.

Coexisting Cystic Lesions with Right-Sided Congenital Diaphragmatic Hernia in a Neonate.

Diaphragmatic defects involving the right side of the diaphragm are less common but represent a distinct entity. The clinical presentation, management, and prognosis differ significantly from a left-sided defect. We report a case of a term neonate who was diagnosed to have a congenital diaphragmatic hernia during the third trimester of pregnancy, operated at 36 h of life and subsequently found to have an associated mediastinal cyst in 1 week of life.

Phytochemical investigation, structural elucidation, study and anti-psoriatic activity of potent bioactive from .

Psoriasis is a chronic autoimmune pathological condition characterized by hyperactivation of proinflammatory cytokines (IL-6, TNF-α, IL-17, IL-23, etc.). Severe drug-associated toxicities like hepatotoxicity and nephrotoxicity (Methotrexate), teratogenicity (Tazarotene), hypercholesterolemia (Cyclosporine) and hypercalcemia (tacalcitol), are the forefront challenges that demand an alternative approach for the treatment of psoriasis.

A comparison of lens parameters in patients with various subtypes of primary angle-closure disease and the normal population: A prospective study.

Purpose: To assess the role of lens parameters in the detection and progression of primary angle-closure disease (PACD) by combining A-scan and A-scan optical coherence tomography (AS-OCT) parameters.

Methods: A cross-sectional study was conducted in a tertiary health-care center in eastern India. A total of 91 study subjects including cases and controls were included in the study.

Positive Antinuclear Antibody (ANA)-Negative Systemic Lupus Erythematosus (SLE) Presenting With Acute Pancreatitis.

Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystem involvement and most commonly affects women of childbearing age. Most of the patients, if not all, have positive antinuclear antibody (ANA) in their serum. ANA-negative SLE is extremely rare.

Clinical presentation and outcome of children with hydatid disease: a retrospective cross-sectional study from a tertiary care hospital in eastern India.

Clinical presentation of echinococcosis in paediatric population is varied and depends on the site of involvement. The present study was planned to analyse the clinical presentations and therapeutic options for management of echinococcosis in children admitted to a tertiary care hospital. Medical records of children with echinococcosis was reviewed retrospectively over a period of 3 year and 6 months.

The recent development of thymol derivative as a promising pharmacological scaffold.

Thymol (a phenol ring bearing active phytoconstituent) is a privileged scaffold, which is diversified in natural sources. This scaffold acts as an obligatory template for scheming and arriving at designing some newer drug-molecules with potential biological activities. In the pharmacological perspective, the promising active sites of the scaffold are the positions C-1, C-4, and C-6 of thymol that would be accountable for developing potent drug candidates.

Palliative and End of Life Care in India - Current Scenario and the Way Forward.

India, being home to one -sixth of the world's population has a huge burden of suffering from life limiting diseases. It is estimated that in India the total no. of people who need palliative care (PC)is likely to be 5.

Genotypic validation of extended-spectrum β-lactamase and virulence factors in multidrug resistance in an Indian hospital.

The emergence of extended-spectrum β-lactamase (ESBL)-producing has been increasing rapidly across the world. The presence of virulence factors in ESBL producers further adds to the pathogenicity and severity of infection, which often complicate empirical therapy and sometimes result in treatment failures. In the present study, 227 non-repeated clinical isolates of obtained from different clinical specimens from a tertiary care hospital in India were analyzed to detect the genes responsible for ESBL production (blaTEM, blaCTX-M, and blaSHV), virulence (fimH-1, mrkD, entB, irp-1), and capsule production (K1-K2).

Gossypiboma complicated with paraspinal abscess and lumbar sinus: An uncommon complication of posterior lumbar spinal surgery.

A 42-year-old female presented with the complaint of purulent discharging sinus over posterior lumbar area following one month of lumbar spinal surgery for prolapsed intervertebral disc. Gossypiboma complicated with paraspinal abscess and sinus track formation over posterior lumbar area was diagnosed in magnetic resonance imaging which was confirmed in re- exploration of lumbar spinal operative site.

Effectiveness of surgically treated symptomatic plano-valgus deformity by the calcaneo stop procedure according to radiological, functional and gait parameters.

Background: The incidence of flatfoot is approximately 5% in children and adults. The symptomatic form of a flexible flatfoot produces subjective and objective complaints, including gait disturbances. Surgical intervention is considered when conservative management fails.

HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India.

Background: Considering the limited cross protection offered by the current HPV vaccines, understanding the HPV genotype distribution among the different population is essential in predicting the efficacy of current vaccine and devising new vaccine strategy. The present work aimed at investigating the HPV genotypes distribution among women with and without cervical carcinoma in Odisha, Eastern India.

Methods: A total of 607 participants have been enrolled between January 2014 and June 2016.

The clinical and biochemical features of complicated falciparum malarial nephropathy.

Objective: This study aimed to explore renal involvement in complicated falciparum malaria as observed in hospitalized children.

Methods: This prospective study was conducted for four consecutive years with children 6 months to 14 years old who were affected by malarial nephropathy. Malaria was confirmed by microscopic examination of a blood smear.

The relationship of abdominal girth with blood pressure, blood sugar and lipid profile among cardiac patients.

Objectives: This study aimed to characterize and identify the relationship of abdominal girth with blood pressure, blood sugar and lipid profile among cardiac patients.

Methods: A total of 100 patients with diagnosed cardiac problems were recruited from the outpatient clinic of a multi-speciality hospital. For data collection, a self-administered questionnaire was used to gather information about patients' demographics and socio-economic status.

Acute hemorrhage within intradural extramedullary schwannoma in cervical spine presenting with quadriparesis.

Schwannoma with acute hemorrhage is rarely seen. A 44-years-old male patient presented with complaint of neck pain and acute onset of quadriparesis. Magnetic resonance imaging (MRI) of his cervical spine revealed evidence of an intradural extramedullary tumor with intratumoral acute hemorrhage.

Congenital dermal sinus in mid-dorsal spine with large intramedullary dermoid cyst in an 18-months-old child.

Intramedullary dermoid cyst is a rare entity. It is usually associated with spinal dysraphism and dermal sinus. Our case is an 18-months-old female child who presented with history of fever and mild difficulty in moving left leg.

An outbreak of hand, foot and mouth disease in Bhubaneswar, Odisha.

Objective: To describe the epidemiology and clinical features of cases in an outbreak of Hand, Foot and Mouth Disease (HFMD).

Design: Descriptive epidemiological study.

Setting: Hospitals and community in urban areas of Bhubaneswar city, Odisha.