1,410 results match your criteria: "Institute of Liver and Biliary Sciences[Affiliation]"
Clin Transplant Res
December 2024
Department of Anaesthesia, Institute of Liver and Biliary Sciences, New Delhi, India.
Virusdisease
December 2024
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, D-1, Vasant Kunj, New Delhi, 110 070 India.
Unlabelled: Antivirals such as nucleotide analogs (NAs) are potent inhibitors of hepatitis B virus (HBV) replication. However, NAs fail to diminish the signaling and mitogenic activities of the transactivator HBx protein. Earlier we have shown that thiourea derivative IR-415 (DSA-00) targeted HBx to down-regulate its target viral and host genes.
View Article and Find Full Text PDFClin Mol Hepatol
December 2024
Departments of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi.
Background And Aims: Acute liver failure (ALF) has high mortality predominantly due to compromised immune system and increase vulnerability to bacterial and fungal infections.
Method: Plasma lipidome and fungal peptide-based-community (mycobiome) analysis were performed in Discovery cohort (40-ALF, 5-healthy) and validated in a validation cohort of 230-ALF using High-resolution-mass-spectrometry, artificial-neural-network (ANN) and machine-learning (ML).
Results: Untargeted lipidomics identified 2,013 lipids across 8 lipid-groups.
J Clin Exp Hepatol
October 2024
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Indian J Anaesth
November 2024
Department of Anaesthesia, Institute of Liver and Biliary Sciences, Delhi, India.
J Mater Chem B
December 2024
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
The limited replicative potential of primary hepatocytes (Hep) is a major hurdle for obtaining sufficient quantity and quality hepatocytes during cell therapy in patients with liver failure. Intrahepatic cholangiocyte organoids (ICOs) derived from intrahepatic bile ducts differentiate into both hepatocytes and cholangiocytes . Here, we studied effects of transplanting ICOs and Hep in chronic liver injury mice models.
View Article and Find Full Text PDFJ Clin Exp Hepatol
October 2024
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
Background/aims: Stereotactic body radiation therapy (SBRT) has evolved as a treatment alternative for advanced hepatocellular carcinoma (HCC) patients who are ineligible for other local therapies. Posttreatment responses are assessed by imaging modalities, serum AFP, and protein induced by vitamin K absence-II (PIVKA) II levels. Despite good specificity, both AFP and PIVKA-II have low to medium sensitivity.
View Article and Find Full Text PDFIndian J Dermatol
October 2024
Department of Radiology, Institute of Liver and Biliary Sciences, New Delhi, India.
Skin colour usually depends upon melanin, haemoglobin, and carotenoids. Pigmentary disorders indicate an increased amount of melanin, leading to a darker colour of the skin, called hypermelanosis. Addison's disease is a rare endocrinal disorder with severe oral and systemic manifestations.
View Article and Find Full Text PDFBraz J Anesthesiol
December 2024
Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Serviço de Anestesia e Medicina Perioperatória, Porto Alegre, RS, Brazil; Santa Casa de Porto Alegre, Serviço de Anestesia, Porto Alegre, RS, Brazil; Hospital Nossa Senhora da Conceição, Serviço de Anestesia, Porto Alegre, RS, Brazil; Programa de Pós-graduação em Ciências Pneumológicas e Programa de Pós-graduação em Ciências Cirúrgicas, UFRGS; Faculdade de Medicina da Universidade de São Paulo (FMUSP), Programa de Pós-Graduação em Anestesiologia, Ciências Cirúrgicas e Medicina Perioperatória, São Paulo, SP, Brazil.
Mol Ther Oncol
December 2024
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
J Clin Exp Hepatol
October 2024
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
J Hosp Infect
December 2024
Department of Hepatology, Punjab Institute of Liver and Biliary Sciences, Mohali, Punjab, India.
J Hepatol
November 2024
Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital, University of Sydney, Sydney, NSW, Australia.
Hepatol Int
November 2024
Department of Hepatology, Institute of Liver and Biliary Sciences, D1 Vasant Kunj, New Delhi, 110070, India.
Background And Aim: Acute-on-chronic liver failure (ACLF) patients with hepatorenal syndrome (HRS-AKI) have limited response to vasoconstrictors and worse outcomes, requiring biomarkers for early detection.
Methods: In a prospective cohort of ACLF patients (n = 240), urine NGAL was performed in patients with the clinical diagnosis of HRS-AKI, while in a subset of patients (n = 30), a complete panel of 17 urinary biomarkers was assessed for identifying terlipressin non-response (T-NR).
Results: ACLF patients with HRS-AKI, aged 45.
Hepatol Int
December 2024
Department of Gastroenterology, Yamanashi Prefectural Center Hospital, Kofu-City, Yamanashi, Japan.
J Gastroenterol Hepatol
November 2024
Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS), New Delhi, India.
Background: Bowel colonization with antimicrobial-resistant bacteria has been associated with worse clinical outcomes in patients with cirrhosis; however, it has not been studied in patients with acute-on-chronic liver failure (ACLF). We evaluated whether fecal isolation of carbapenem-resistant gram-negative bacteria (CR-GNB) among patients with ACLF affects short-term outcomes.
Methods: Patients of APASL-ACLF (n = 339) were screened between June 2020 and December 2021, and 150 were included.
J Clin Exp Hepatol
October 2024
Director, Punjab Institute of Liver and Biliary Sciences, Mohali, Punjab, India.
J Clin Exp Hepatol
October 2024
Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
J Pediatr Gastroenterol Nutr
November 2024
Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Mutations in doublecortin domain-containing protein 2 (DCDC2) lead to neonatal sclerosing cholangitis (NSC), and portal hypertension (PHTN). The objective of the study was to systematically evaluate PHTN, variceal bleeding, and outcomes of patients with DCDC2-related NSC. The study included children with homozygous or compound heterozygous variants in DCDC2.
View Article and Find Full Text PDFChem Asian J
November 2024
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.
Injectable hydrogels are a sub-type of hydrogels which can be delivered into the host in a minimally invasive manner. They can act as carriers to encapsulate and deliver cells, drugs or active biomolecules across several disease conditions. Polymers, either synthetic or natural, or even a combination of the two, can be used to create injectable hydrogels.
View Article and Find Full Text PDFIndian J Gastroenterol
November 2024
Department of Biostatistics and Health Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.
Hepatol Int
December 2024
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Since the Asian Pacific Association for the Study of the Liver (APASL) published guidelines on non-cirrhotic portal fibrosis/idiopathic portal hypertension in 2007, there has been a surge in new information, especially with the introduction of the term porto-sinusoidal vascular disorder (PSVD). Non-cirrhotic intra-hepatic causes of portal hypertension include disorders with a clearly identifiable etiology, such as schistosomiasis, as well as disorders with an unclear etiology such as non-cirrhotic portal fibrosis (NCPF), also termed idiopathic portal hypertension (IPH). This entity is being increasingly recognized as being associated with systemic disease and drug therapy, especially cancer therapy.
View Article and Find Full Text PDFCureus
October 2024
Hepatopancretaobiliary Surgery, Institute of Liver and Biliary Sciences, Delhi, IND.
Purpose: The early post-transplant period after liver transplantation is critical, as recipients are highly susceptible to sepsis due to their immune-compromised state. This study aimed to identify the association between preoperative procalcitonin and early post-transplant sepsis and mortality at one month after living donor liver transplantation (LDLT).
Methodology: All patients who underwent LDLT from July 2021 to December 2021 were recruited prospectively.
J Hepatol
November 2024
Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: