607 results match your criteria: "Institute of Intelligent Machines[Affiliation]"

An ideal green leaf-deposited pesticide formulation should offer advantages such as good water dispersibility, strong foliar affinity, sustained or controlled release of active ingredients, photostability and rain-fastness, minimal nontarget toxicity, use of nontoxic organic solvents, and degradable adjuvants. In line with this objective, we present green preparation of a colloidal pesticide formulation using optimized lysine-derived carbon dots (LysCDs)-modified CaCO (LysCDs/CaCO) particles as the carrier and abamectin (Abm) as the active ingredient. The loading capacity of abamectin in this colloidal pesticide (LysCDs/CaCO/Abm) is 1.

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A meniscus injury is a prevalent condition affecting the knee joint. The construction of a subjective prediction model for meniscus injury represents a potentially invaluable diagnostic tool for physicians. Nevertheless, given the variability of pathological manifestations among individual patients, machine learning-based models may produce errors when attempting to predict specific medical records.

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Background: Personalized intelligent exercise prescriptions have demonstrated significant benefits in increasing physical activity and improving individual health. However, the health benefits of these prescriptions depend on long-term adherence. Therefore, it is essential to analyze the factors influencing adherence to personalized intelligent exercise prescriptions and explore the intrinsic relationship between individual behavioral motivation and adherence.

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Bioinspired design and validation of a soft robotic end-effector with integrated shape memory alloy-driven suction capabilities.

Bioinspir Biomim

December 2024

Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, People's Republic of China.

The exploration of adaptive robotic systems capable of performing complex tasks in unstructured environments, such as underwater salvage operations, presents a significant challenge. Traditional rigid grippers often struggle with adaptability, whereas bioinspired soft grippers offer enhanced flexibility and adaptability to varied object shapes. In this study, we present a novel bioinspired soft robotic gripper integrated with a shape memory alloy (SMA) actuated suction cup, inspired by the versatile grasping strategies of octopus arms and suckers.

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Using Label-Free Raman Spectroscopy Integrated with Microfluidic Chips to Probe Ferroptosis Networks in Cells.

Appl Spectrosc

November 2024

CAS Key Laboratory of Ion-Beam Bioengineering, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.

Ferroptosis, a regulated form of cell death driven by oxidative stress and lipid peroxidation, has emerged as a pivotal research focus with implications across various cellular contexts. In this study, we employed a multifaceted approach, integrating label-free Raman spectroscopy and microfluidics to study the mechanisms underpinning ferroptosis. Our investigations included the ferroptosis initiation based on the changes in the lipid Raman band at 1436 cm under different cellular states, the generation of reactive oxygen species (ROS), lipid peroxidation, DNA damage/repair, and mitochondrial dysfunction.

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Early-stage Alzheimer's disease profiling in blood achieved by multiplexing aptamer-SERS biosensors.

Biosens Bioelectron

January 2025

CAS Key Laboratory of Ion-beam Bioengineering, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China; Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, 230026, China. Electronic address:

Neurological disorders are the second leading cause of death globally, with Alzheimer's disease (AD) emerging as a significant contributor, responsible for 276 million cases in disability-adjusted life years. Conventional diagnostic methods are often invasive, costly, and place a considerable strain on global healthcare systems. In this study, we presented an innovative and efficient strategy for AD assessment through blood profiling using a multiwell glass chip integrated with aptamer-based surface-enhanced Raman scattering (SERS) biosensors.

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Objective: To investigate the prevalence of low bone mineral density (BMD) along with its possible risk factors in male Han Chinese patients with alcohol dependence (AD).

Methods: This retrospective, cross-sectional study included male patients with AD, classified into normal and low BMD groups according to bone densitometry T scores. Demographic and alcohol-related data, and routine laboratory parameters were compared between the two groups.

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Ectonucleotidase inhibitors: an updated patent review (2017-2023).

Expert Opin Ther Pat

November 2024

Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.

Article Synopsis
  • The main enzymes responsible for breaking down nucleotides at the cell surface are NTPDases, ENPPs, alkaline phosphatases, and e5'NT, which can influence various health conditions like cancer and inflammation, making them potential therapeutic targets.
  • This review focuses on ectonucleotidase inhibitors, including both nucleoside/nucleotide analogues and bicyclic compounds, that have been patented between 2017 and 2023, highlighting their chemistry and clinical applications.
  • The review emphasizes the importance of nucleotides in regulating key physiological processes and discusses the therapeutic potential of small molecules that affect ectonucleotidase activity, including advancements in combination therapy and selectivity.
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Geckos are renowned for their exceptional climbing abilities, enabled by their specialized feet with hairy toes that attach to surfaces using van der Waals forces. Inspired by these capabilities, various gecko-like robots have been developed for high-risk applications, such as search and rescue. While most research has focused on adhesion mechanisms, the gecko's tail also plays a critical role in maintaining balance and stability.

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Near-infrared-II (NIR-II) fluorescence imaging-guided photothermal therapy (PTT) represents a cutting-edge approach for precise tumor diagnosis and treatment, providing real-time therapeutic efficacy evaluation. However, a significant challenge lies in the creation of phototheranostic agents that provide robust imaging and efficient photothermal conversion. To address this, a donor-π-acceptor (D-π-A) structure heptamethine cyanine derivative, IR1116, that confers a strong intramolecular charge transfer effect is developed.

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Urease catalyzes the hydrolysis of urea, leading to an increase in stomach pH and supporting Helicobacter pylori survival, which is linked to several gastrointestinal disorders. In this study, thiazine-based Schiff bases were explored as promising urease inhibitors. Various spectroscopic techniques characterized the synthetic library of thiazine Schiff bases 2-36 and also evaluated for their inhibitory activities against urease.

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Article Synopsis
  • * Its medicinal benefits are linked to its chemical composition, which includes polysaccharides and alkaloids, allowing it to inhibit tumor growth and promote cell health.
  • * Recent research has increasingly focused on the active compounds in Dendrobium, highlighting the need for ongoing studies to better understand its components and their potential clinical applications.
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Elucidating the protective mechanism of ganoderic acid DM on breast cancer based on network pharmacology and in vitro experimental validation.

Biotechnol Appl Biochem

September 2024

CAS Key Laboratory of High Magnetic Field and Iron Beam Physical Biology, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.

Ganoderma lucidum, a popular medicinal fungus, has been utilized to treat a variety of diseases. It possesses a unique therapeutic and pharmacological reputation in suppressing cancer/tumor progression, especially breast cancer, due to its embedded rich bioactive chemical constituents, mainly triterpenoids (ganoderic acids). The most prevalent malignant tumor in women with a high mortality and morbidity rate is breast cancer.

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LTP-assisted fabrication of laccase-like Cu-MOF nanozyme-encoded array sensor for identification and intelligent sensing of bioactive components in food.

Biosens Bioelectron

January 2025

CAS Key Laboratory of High Magnetic Field and Iron Beam Physical Biology, Institute of Intelligent Machines, Hefei Institute of Physical Sciences, Chinese Academy of Sciences, Hefei, 230031, China; Science Island Branch of Graduate School, University of Science and Technology of China, Hefei, 230026, China. Electronic address:

Nanozymes are potential candidates for constructing sensors due to their adjustable activity, high stability, and high cost-effectiveness. However, due to the lack of reasonable means, designing and preparing efficient nanozymes remains challenging. Herein, inspired by the property of natural laccase, we applied the novel and facile low-temperature plasma (LTP) technology to fabricate a series of different base-ligand Cu metal organic framework (MOF) nanozymes (namely, A-Cu, G-Cu, C-Cu and T-Cu nanozymes) with laccase-like activity successfully.

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A method combining LDA and neural networks for antitumor drug efficacy prediction.

Digit Health

September 2024

Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China.

Background: Personalized medicine has gained more attention for cancer precision treatment due to patient genetic heterogeneity in recent years. However, predicting the efficacy of antitumor drugs in advance remains a significant challenge to achieve this task.

Objective: This study aims to predict the efficacy of antitumor drugs in individual cancer patients based on clinical data.

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A new method is introduced for the swift and precise detection of soil pollution and its effects on crops. Soil quality is essential for human well-being, with heavy metal pollution presenting considerable risks to both the ecological environment and human health. In crops, heavy metal contamination primarily occurs through mediums such as soil and water sources.

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Dual inhibitory potential of ganoderic acid A on GLUT1/3: computational and insights into targeting glucose metabolism in human lung cancer.

RSC Adv

September 2024

CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences Hefei 230031 China

Human glucose transporters (GLUTs) facilitate the uptake of hexoses into cells. In cancer, the increased proliferation necessitates higher expression of GLUTs, with particular emphasis on GLUT1 and GLUT3. Thus, inhibiting GLUTs holds promise as an anticancer therapy by starving these cells of fuel.

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Study on the changing patterns of production performance of laying hens and their relationships with environmental factors in a large-scale henhouse.

Poult Sci

November 2024

Anhui Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Science, Hefei, Anhui, 230031, China. Electronic address:

The production performance of laying hens is influenced by various environmental factors within the henhouse. The intricate interactions among these factors make the impact process highly complicated. The exact relationships between production performance and environmental variables are still not well understood.

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Novel insight into the feed conversion ratio in laying hens and construction of its prediction model.

Poult Sci

October 2024

Anhui Provincial Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei, Anhui 230031, China. Electronic address:

Feed efficiency (FE) is an important economic factor in poultry production, and feed conversion ratio (FCR) is one of the most widely used measures of FE. Factors associated with FCR include genetics, the environment, and other factors. However, the mechanisms responsible for FCR in chickens are still less well appreciated.

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Erianin, a bibenzyl compound found in dendrobium extract, has demonstrated broad anticancer activity. However, its mechanism of action in gastric cancer (GC) remains poorly understood. is a tumor-suppressor gene, and its mutation is an important driver of various cancers.

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We report herein chemical and electrochemical ammonia oxidation (AO) catalyzed by a Ru complex, [Ru(HL)(pic)] [, HL = 6,6'-di(1H-pyrazol-3-yl)-2,2'-bipyridine, pic = 4-picoline], where HL is a tetradentate ligand with a bipyridyl unit connected to two pyrazoles. functions as an efficient electrocatalyst for the oxidation of NH to N, with a low overpotential of 0.51 V vs Fc and a Faradaic efficiency of 96%.

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Causality-inspired crop pest recognition based on Decoupled Feature Learning.

Pest Manag Sci

November 2024

Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.

Background: Ensuring the efficient recognition and management of crop pests is crucial for maintaining the balance in global agricultural ecosystems and ecological harmony. Deep learning-based methods have shown promise in crop pest recognition. However, prevailing methods often fail to address a critical issue: biased pest training dataset distribution stemming from the tendency to collect images primarily in certain environmental contexts, such as paddy fields.

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Effectively monitoring pest-infested areas by computer vision is essential in precision agriculture in order to minimize yield losses and create early scientific preventative solutions. However, the scale variation, complex background, and dense distribution of pests bring challenges to accurate detection when utilizing vision technology. Simultaneously, supervised learning-based object detection heavily depends on abundant labeled data, which poses practical difficulties.

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Discrimination of internal crack for rice seeds using near infrared spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc

October 2024

Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China; University of Science and Technology of China, Hefei 230026, China.

It is an important thing to identify internal crack in seeds from normal seeds for evaluating the quality of rice seeds (Oryza sativa L.). In this study, non-destructive discrimination of internal crack in rice seeds using near infrared spectroscopy and chemometrics is proposed.

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Surface electromyogram (sEMG) signals have been widely used in human upper limb force estimation and motion intention recognition. However, the electrocardiogram(ECG) artifact generated by the beating of the heart is a major factor that reduces the quality of the EMG signal when recording the sEMG signal from the muscle close to the heart. sEMG signals contaminated by ECG artifacts are difficult to be understood correctly.

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