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Membrane current series monitoring: essential reduction of data points to finite number of stable parameters.
Front Comput Neurosci
October 2014
Department of Radioelectronics, Institute of Physics, Kazan Federal University Kazan, Russia ; Department of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics Russian Academy of Sciences Kazan, Russia ; Department of Bioinformatics, Institute of Informatics Kazan, Russia.
In traditional studies of changes in cell membrane potential or trans-membrane currents a large part of the recorded data presents "a pure noise." This noise results mainly from the random openings of membrane ionic channels. Different types of stationary or non-stationary noise analysis have been used in electrophysiological experiments for identification of channels kinetic states.
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