1,620 results match your criteria: "Institute of Inflammation and Ageing.[Affiliation]"
Nat Med
January 2025
Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Anaesth Crit Care Pain Med
December 2024
Department of Critical Care Medicine, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, United Kingdom. Electronic address:
Background: Patients with Self-Reported Penicillin Allergy (SRPA) receive alternative antibiotics, which increase the length of stay and hospital costs, but the impact of SRPA on mortality in critically ill patients is not well described.
Methods: This was a single-center, retrospective analysis of routinely gathered clinical data for all intensive care unit (ICU) admissions over nine years. The primary outcome was 28-day mortality, which was analyzed using a time-to-event approach with multivariable models to adjust for confounding factors, including age, comorbidities, sex, and admission SOFA score (as a measure of organ dysfunction).
J Gerontol A Biol Sci Med Sci
December 2024
Human Nutrition & Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method.
View Article and Find Full Text PDFClin Exp Rheumatol
December 2024
Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, and National Institute of Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Unlike other autoimmune diseases, little is known about the environmental risk factors for Sjögren's disease (SjD). Smoking is an important risk factor for rheumatoid arthritis but the relationship between smoking and SjD is more complex to understand. Current smoking seems to be negatively linked to SjD, whereas there is mixed data on past smoking.
View Article and Find Full Text PDFThorax
December 2024
Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Objective: Community-acquired pneumonia (CAP) is a leading cause of hospitalisation in older adults and is associated with a high likelihood of adverse outcomes. Given the ageing population and lack of therapeutic advances in CAP, new strategies to manage the burden of this disease are needed. Neutrophil dysfunction has been widely demonstrated in CAP and is associated with poor outcomes.
View Article and Find Full Text PDFJ Thorac Dis
November 2024
Department of Thoracic Surgery, University Hospitals Birmingham, Birmingham, UK.
Background: Benign airway stenoses are complex disorders that present with progressive dyspnoea, stridor, and significant respiratory distress. These conditions have a high recurrence rate and despite the plethora of endoscopic and open techniques available for treatment, the outcomes are variable. Our primary was to determine the pre-operative factors associated with an increased hazard of cricotracheal resection (CTR)/tracheal resection (TR) and reconstruction in cases of benign subglottic and tracheal strictures.
View Article and Find Full Text PDFNeural Regen Res
January 2025
Department of Pharmacology and Toxicology, Maastricht University, Maastricht, The Netherlands (Manukjan N, Blankesteijn WM, Foulquier S).
Arch Dis Child
December 2024
Institute of Health and Neurodevelopment, Aston University, Birmingham, UK
Objective: The aim of this study was to explore parents' views and experiences of managing preschool wheeze, including opinions on the use of investigations to inform treatment pathways.
Design: Purposive sampling was used to recruit 16 participants from 14 families across England and Wales. Qualitative data were collected via semi-structured interviews with parents of children aged 1-5 years with preschool wheeze, conducted on Microsoft (MS) Teams.
Rheumatology (Oxford)
December 2024
Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Objectives: Cutaneous vasculitis (CV) is common in SLE, but the epidemiology and risk factors remain unclear. We aimed to identify the trends and risk factors for CV in patients with SLE over a period of 20 years.
Methods: The Birmingham Lupus Cohort is an observational longitudinal cohort of SLE patients.
Proc Natl Acad Sci U S A
December 2024
Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton-sensitive receptors is challenging due to their diversity and widespread expression. Here, agonists of the proton-sensing GPCR, GPR65, were systematically characterized. The synthetic agonist BTB09089 (BTB) recapitulated many proton-induced signaling events and demonstrated selectivity for GPR65.
View Article and Find Full Text PDFJAMA
December 2024
Warwick Medical School, Clinical Trials Unit, University of Warwick, Coventry, United Kingdom.
Importance: For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.
Objective: To determine whether decisions based on assessment of CRP or PCT safely results in a reduction in the duration of antibiotic therapy.
Design, Setting, And Participants: A multicenter, intervention-concealed randomized clinical trial, involving 2760 adults (≥18 years), in 41 UK National Health Service (NHS) intensive care units, requiring critical care within 24 hours of initiating intravenous antibiotics for suspected sepsis and likely to continue antibiotics for at least 72 hours.
Front Endocrinol (Lausanne)
December 2024
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Background And Aim: Head and neck paragangliomas (HNPGN) are tumours that carry significant morbidity The role of the stroma in the pathogenesis of HNPGN is not completely understood. This study explores the profile of fibroblasts and macrophages in HNPGN.
Methods: Ten patients undergoing HNPGN surgery were recruited.
Clin Imaging
November 2024
University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; National Institute for Health and Care Research Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK; Birmingham Health Partners Centre for Regulatory Science and Innovation, University of Birmingham, Birmingham, UK. Electronic address:
Cochrane Database Syst Rev
November 2024
Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Rheumatol Adv Pract
November 2024
Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK.
Aging Cell
November 2024
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
The intestinal epithelium serves as a physical and functional barrier against harmful substances, preventing their entry into the circulation and subsequent induction of a systemic immune response. Gut barrier dysfunction has recently emerged as a feature of ageing linked to declining health, and increased intestinal membrane permeability has been shown to promote heightened systemic inflammation in aged hosts. Concurrent with age-related changes in the gut microbiome, the thymic microenvironment undergoes a series of morphological, phenotypical and architectural alterations with age, including disorganisation of the corticomedullary junction, increased fibrosis, increased thymic adiposity and the accumulation of senescent cells.
View Article and Find Full Text PDFBioeng Transl Med
November 2024
Neuroscience and Ophthalmology Institute of Inflammation and Ageing, University of Birmingham Birmingham UK.
Spinal cord injury (SCI) is a cause of profound and irreversible damage, with no effective therapy to promote functional recovery. Photobiomodulation (PBM) may provide a viable therapeutic approach using red or near-infrared light to promote recovery after SCI by mitigating neuroinflammation and preventing neuronal apoptosis. Our current study aimed to optimize PBM dose regimens and develop and validate the efficacy of an invasive PBM delivery paradigm for SCI.
View Article and Find Full Text PDFBrain
November 2024
Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy.
Rodent models are important research tools for studying the pathophysiology of traumatic brain injury (TBI) and developing new therapeutic interventions for this devastating neurological disorder. However, the failure rate for the translation of drugs from animal testing to human treatments for TBI is 100%. While there are several potential explanations for this, previous clinical trials have relied on extrapolation from preclinical studies for critical design considerations, including drug dose optimization, post-injury drug treatment initiation and duration.
View Article and Find Full Text PDFAcute Med
November 2024
PhD. Director of PIONEER: Health Data Research UK (HDRUK) Health Data Research Hub for Acute Care, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 2GW, UK. ORCiD ID: 0000-0003-3454-5482, NIHR West Midlands Applied Research Centre, University of Birmingham, B15 2TT, UK, NIHR Midlands Patient Safety Research Collaboration, University of Birmingham, B15 2TT, NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham, B15 2GW.
Background: Medical research improves patient outcomes, patient satisfaction, staff morale and retention. It is unclear what research opportunities and training staff in acute medicine had.
Methods: The Society for Acute Medicine supported a survey to assess current research activity, training and perceived opportunities and barriers.
Acute Med
November 2024
Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, CV4 7AL, UK and Division of Acute General Medicine, Oxford University Hospitals NHS Foundation Trust, Headington, Oxford. OX3 9DU.
Performance within acute medicine services is impacted by ongoing pressures on acute care services. Data from the Society for Acute Medicine Benchmarking Audit 2023 (SAMBA23), was used to assess performance of acute medicine services compared to key clinical quality indicators, comparing performance by initial assessment location. Data was analysed for 8213 unplanned attendances across 161 hospitals.
View Article and Find Full Text PDFEur Respir J
November 2024
Clinical and Experimental Sciences and Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Neuroimage
December 2024
School of Sport, Exercise and Rehabilitation Sciences, University Birmingham, Birmingham, UK; Centre for Human Brain Health, University Birmingham, Birmingham, UK.
Brain vascular health worsens with age, as is made evident by resting grey matter cerebral blood flow (CBF) reductions and lengthening arterial transit time (ATT). Exercise training can improve aspects of brain health in older adults, yet its effects on CBF and ATT remain unclear. This randomised controlled trial assessed responses of CBF and ATT to a 26 week exercise intervention in 65 healthy older adults (control: n = 33, exercise: n = 32, aged 60-81 years), including whether changes in CBF or ATT were associated with changes in cognitive functions.
View Article and Find Full Text PDFFront Immunol
November 2024
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Platelets
December 2024
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Severe thermal injury significantly impacts upon hemostasis and is associated with classical changes to the circulating platelet count with a nadir followed by a rebound thrombocytosis at days ~3 and ~15 post-injury, respectively. To date, few studies have assessed platelet function following thermal injury as platelet tests often require large quantities of blood, are not representative of normal platelet pathophysiology, and are usually dependent on a normal platelet count. The purpose of this study was to measure platelet thrombus formation using a whole blood flow chip-based system following thermal injury and to study how platelet counts may impact upon the measurement.
View Article and Find Full Text PDFMicrob Genom
November 2024
Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Vulnerable patients in an intensive care unit (ICU) setting are at high risk of infection from bacteria including gut-colonising and species. Complex ICU procedures often depend on successful antimicrobial treatment, underscoring the importance of understanding the extent of patient colonisation by multi-drug-resistant organisms (MDROs) in large UK ICUs. Previous work on ICUs globally uncovered high rates of colonisation by transmission of MDROs, but the situation in UK ICUs is less understood.
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