[Stereotactic photodynamic therapy for recurrent glioblastoma. Case report and literature review].

We report a patient with recurrent glioblastoma in eloquent brain area. Stereotactic fluorescence biospectroscopy and stereotactic photodynamic therapy of tumor in opercular area of the left frontal lobe under neurophysiological monitoring were carried out. Literature data on this issue were analyzed.

[Dyslexia as a multideficit disorder].

The article provides a review of research on dyslexia. Various views on the role of genetic and environmental factors in the etiology and pathogenesis of this disorder are examined. The results of neurophysiological and neuropsychological studies are presented, indicating a disturbance of some higher mental functions in dyslexia.

[Morphofunctional characteristic of the microvasculature of the lung tissue in acute fatal ethanol poisoning].

The purpose of this work is an in-depth study of main morphological features and pathogenesis of acute lung injury in cases of acute fatal poisoning with ethanol; assessment of microcirculation disorders in the respiratory system; details of the mechanisms of development of non-cardiogenic pulmonary edema. An analysis of 160 deaths of men and women aged 19 to 85 years from acute ethanol poisoning was made. Histological preparations were colored with hematoxylin and eosin according to the Van Gieson method, elastic fibers - according to Weigert.

[Asthenic disorders. History and modernity].

The article presents a review of publications devoted to asthenic disorders. The authors consider the various views on the etiology and basic mechanisms of the pathogenesis of asthenia and features of clinical manifestations of various diseases with asthenia as a key syndrome, as well as modern approaches to the treatment of these disorders.

[Electroencephalographic signs of burnout syndrome].

Objective: To study the electroencephalographic manifestations of the various stages of burnout syndrome (BS).

Material And Methods: A quantitative analysis of the EEG of 131 patients, aged 25 to 45 years, with BS was performed. The control group included 143 people.

[A device for endoluminal thermal obliteration of varicose veins].

Amongst the techniques of endoluminal thermal obliteration of varicose veins, the most commonly employed treatment modalities are endovasal radiofrequency ablation and endovasal laser obliteration, both using a generating source and a special device for carrying out thermal obliteration. It has been noted that each of the methods of thermal obliteration has a number of disadvantages, irrespective of using the energy of magnetic oscillations in a radiofrequency range or laser radiation, including high cost of expendable materials and equipment. The device we worked out for endoluminal thermal obliteration of varicose veins was based on the principle of high efficacy and safety, with a significant decrease in the cost of carrying out the manipulation.

Tetrabutylammonium tosylate as inert phase-transfer catalyst: The key to high efficiency S2 radiofluorinations.

Here we describe use of the tetrabutylammonium p-toluenesulfonate (TBAOTs) as an inert phase transfer catalyst allowing high efficient aliphatic radiofluorination of labeling precursors for the preparation of common radiotracers using only 0.2-1.2 mg of the substrates.

[Disturbances of executive functions in children with emotional and behavioral dysregulation].

Objective: To study a role of executive functions in the development of organic emotionally labile (asthenic) disorder (OELD) and oppositional defiant disorder (ODD).

Material And Methods: The study included 66 patients, aged 6 to 8 years, including 36 children with OELD and 30 children with ODD. Fatigue was assessed by parents on a 10-point digital rating scale.

Low-Intensity Physical Exercise Improves Pain Catastrophizing and Other Psychological and Physical Aspects in Women with Fibromyalgia: A Randomized Controlled Trial.

Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain and other physical and psychological features. In this study, we aimed to analyze the effect of a low-intensity physical exercise (PE) program, combining endurance training and coordination, on psychological aspects (i.e.

Cerebral toxoplasmosis in HIV-infected patients over 2015-2018 (a case study of Russia).

Cerebral toxoplasmosis is a leading cause of the central nervous system disorders in acquired immune deficiency syndrome. This study aimed to investigate the clinical course of cerebral toxoplasmosis in human immunodeficiency virus (HIV)-infected individuals. The study included 90 HIV-infected patients with cerebral toxoplasmosis, who underwent inpatient treatment.

Synthesis and Preclinical Evaluation of 6-[F]Fluorine-α-methyl-l-tryptophan, a Novel PET Tracer for Measuring Tryptophan Uptake.

The positron emission tomography (PET) radioligand α-[C]methyl-l-tryptophan ([C]AMT) has been used to assess tryptophan metabolism in cancer, epilepsy, migraine, and autism. Despite its extensive application, the utility of this tracer is currently hampered by the short half-life of the radionuclide used for its labeling (C, = 20.4 min).

[Typology of impaired attention in children and related behavioral disorders].

A review of publications devoted to the study of impaired attention in children is presented. The authors identified the main types of impaired attention, examined the main psycho-neurological diseases, in which impaired attention is the leading symptom, and approaches to treatment of these disorders.

[Results of a phase 1 clinical study of anti-CD20 monoclonal antibody (BCD-132): pharmacokinetics, pharmacodynamics and safety].

Aim: To study the pharmacokinetics, pharmacodynamics, and immunogenicity of two intravenous dosing regimens of the new anti-B-cells drug BCD-132 (JSC BIOCAD, Russia) at ascending doses in patients with remitting multiple sclerosis.

Material And Methods: Twenty-four patients with multiple sclerosis were sequentially randomized in the multicenter open-label uncontrolled multicohort phase I study (3+3 design) and assigned to 4 cohorts (8 groups). Patients in each cohort received an intravenous infusion of BCD-132 at a predefined dose ranging from 100 to 1000 mg based on the planned algorithm of dose escalation if no dose-limiting toxicities occurred.

[Possibilities of using Cytoflavin in the treatment of cognitive and emotional disorders in patients with tension headaches].

Objective: To evaluate the efficacy and safety of Сytoflavin in the treatment of cognitive and emotional disorders in patients with tension headache.

Material And Methods: Fifty patients with tension headache, aged from 18 to 50 years, were studied. The following methods and tests were used: neurological examination, NPRS, STAI, CFQ, RAVLT, TOVA, electroencephalography (routine and spectral analysis).

[Cognitive disturbances in children with chronic tics and their treatment].

Aim: To clarify the severity of cognitive disturbances in children with chronic tics and to evaluate the efficacy of cortexin as part of complex therapy in the treatment of this pathology.

Material And Methods: The main study group included 50 children, aged 6-8 years, with chronic motor tics. Twenty patients of these group received phenibut and 30 patients received cortexin in addition to phenibut.

Synthesis and biological evaluation of [F]fluorovinpocetine, a potential PET radioligand for TSPO imaging.

Despite of various PET radioligands targeting the translocator protein TSPO 18-KDa are used for the investigations of neuroinflammatory conditions associated with neurological disorders, development of new TSPO radiotracers is still an active area of the researches with a major focus on the F-labelled radiotracers. Here, we report the radiochemical synthesis of [F]vinpocetine, fluorinated analogue of previously reported TSPO radioligand, [C]vinpocetine. Radiolabeling was achieved by [F]fluoroethylation of apovincaminic acid with [F]fluoroethyl bromide.

[C-methionine PET in assessment of brain lesions in patients with glial tumors after combined treatment].

Positron emission tomography (PET) with amino acid-based radiopharmaceuticals is considered as an effective method to diagnose continued growth of cerebral gliomas, but the variability of C-methionine uptake by brain lesions of different genesis after combined treatment still remains poorly understood. The aim of this study was to explore the information value of C-methionine PET in delimitating progression of cerebral gliomas and stable disease and to assess the risk of tumor recurrence at different values of the C-methionine uptake index. MATERIAL AND METHODS: We performed a retrospective analysis of the results of C-methionine PET or PET/CT in 324 patients suspected for continued growth of cerebral tumor based on magnetic resonance imaging (MRI) findings.

[Impairments of cognitive control in patients with somatoform disorders and their treatment].

Aim: To study impairments of cognitive control in patients with somatoform disorders (SD) and to evaluate the efficacy of recognan in the treatment of this pathology.

Material And Methods: Forty-six patients with SD, aged from 18 to 45 years, were studied. A clinical history, neurological examination, and assessment of autonomic disorders were collected from all patients.

Use of capillary electrophoresis for the determination of impurities in preparations of fluorine-18 labelled PET radiopharmaceuticals.

Fluorine-18 labelled radiotracers are the most common diagnostic agents employed in positron emission tomography (PET). Despite well-established quality control (QC) procedures, introduction of new synthetic methods demands continuous development of analytical methodology. Here we propose capillary electrophoresis (CE) as a simple, fast and cost-efficient analytical method, allowing for the evaluation of potentially toxic impurities, including transition metals, in the formulated preparations.

[Cognitive control impairment in adult with attention deficit/hyperactivity disorder].

Aim: To study cognitive impairment in adults with attention deficit hyperactivity disorder (ADHD) and assess the efficacy of cerebrolysin in the treatment of such patients.

Material And Methods: Thirty-eight patients with ADHD, aged from 18 to 45 years were enrolled in the study. Along with general neurological examination, several ADHA-specific scales and tests (ASRS-V1-1, SFQ, BIS, the Emotional Intelligence Self-Evaluation, TOVA) were administered.

[Emotional disorders in adolescents with Tourette's syndrome and in their mothers].

Aim: To study anxiety disorders in adolescents with Tourette syndrome (TS) and in their mothers.

Material And Methods: Twenty-seven teenagers with TS, aged from 12 to 15 years, and their mothers were included in the main group. The control group consisted of 30 healthy adolescents and their mothers.

[A case-report of Balo concentric sclerosis transformed into definite multiple sclerosis].

The authors present the results of an 8-year retrospective-prospective follow-up of a patient with Balo concentric sclerosis. The disease meets the diagnostic criteria of remitting-relapsing multiple sclerosis.

[Provision of alemtuzumab safety is one of the main components of pharmacovigilance].

Modern multiple sclerosis therapy with disease-modifying drugs is characterized by the risks of dangerous infectious complications. In the last 5 years, there have been several reports of severe, sometimes lethal, listeriosis infection in patients treated with alemtuzumab. This article presents a clinical case of lethal listeriosis meningoencephalitis, which developed within 7 days after the completion of the first cycle of alemtuzumab therapy.

[Comorbid cognitive impairments in children with nocturnal enuresis and their treatment].

Aim: To study comorbid cognitive impairments in children with enuresis and assess the efficacy and safety of cerebrolysin in treatment of comorbid pathology.

Material And Methods: Seventy patients, aged from 7 to 10 years, with the primary monosymtomatic form of enuresis were examined. Enuresis was assessed by the mean number of 'wet' nights per week.